Evidence-Based Protocols for the Prevention and Treatment of Prosthetic Joint Infection in Total Hip Arthroplasty: A Systematic Review

Table 2.

Treatment Protocols for Prosthetic JointInfection (PJI)

Protocol Indications Reported Outcomes

DAIR [4,6] Acute PJI (<4 weeks); stable implant; short symptom duration Higher failure in S. aureus (21%) vs. Streptococcus spp. (0%)
No-Spacer Protocol [2] Severe infection or joint destruction; reduces spacer complications 33% failure rate; avoids spacer-related complications
Two-stage Revision [2,3,17,26] Resistant/multimicrobial infections; poor soft tissue quality High eradication (82-100%), but higher morbidity
DAPRI [7] Modified DAIR with biofilm-targeting techniques 80% success rate; improved biofilm eradication
One-stage Revision [1,23] Known organism, stable patient, no sinus tract or sepsis Lower morbidity, shorter LOS, fewer complications
Muscle Flaps [30] Large soft tissue defects or failed revision; used in limb salvage 97-100% success rate; provides durable coverage and infection control

Legend: PJI = Prosthetic Joint Infection; THA = Total Hip Arthroplasty; DAIR = Debridement, Antibiotics, Irrigation, and Retention; DAPRI = Debridement, Antibiotic Pearls, and Retention of the Implant; LOS = Length of Stay.