Global Journal of Cardiovascular Diseases <p>Global Journal of Cardiovascular Diseases(GJCD) is an international journal dedicated to the latest advancement in Cardiovascular Diseases. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Cardiovascular Diseases.</p> en-US (Robert Williams) (Robert Williams) Sat, 22 Jul 2023 05:33:18 +0000 OJS 60 Covid-19-Associated Myopericardial Injury: A Macro and Microscopic Description <p>Authors describe autoptic findings of two cases whose COVID-19 diagnosis was supported by laboratory data. Both patients were Caucasian individuals of middle age (one male, 47 years old; the other a female aging 36 years) that were considered as previously healthy. Clinically they died from cardiorespiratory insufficiency while being treated in intensive care units. None of them was intubated and blood oxygen levels (SpO2) decreased below 90% only during the agonal phase. Myopericardial changes were visible from a macroscopic point of view, with hemorrhagic and necrotic areas involving pericardium. Fresh hemorrhage and severe hyperemia were both signs of vascular damage and extravasation leading to acute myocardial injuries. Lymphocytic presence was disparate and not constant.</p> Arben Lloja, Bledar Xhemali, Elton Serani, Gentian Vyshka Copyright (c) 2023 Global Journal of Cardiovascular Diseases Fri, 21 Jul 2023 00:00:00 +0000 Key Factor to Prevent Aortic Root and Descending Thoracic Aorta Enlargement after Aortic Valve and Ascending Aorta Combined Surgery <p><strong>Objective</strong>: aortic root enlargement (ARE) and descending thoracic aorta dilatation (DTAD) in combined aortic valve and ascending aorta replacement surgery (AV+AAR) are postoperative concerning issues. This retrospective observational analysis studies surgical factors which could determine those complications. <strong>Methods</strong>: 236 patients underwent AV+AAR. Mean-time follow-up by trans-thoracic echocardiography (TTE) and computer tomography (CT) was 44.7 ± 21.2 and 38.2 ± 18.4 months respectively. In long-term follow-up, outcome variables are: ARE equal/more than 10% of the preoperative TTE data and DTAD equal more than 5% of preoperative CT measurement at the same thoracic vertebrae axial slice. <strong>Results</strong>: ARE and DTAD appear strictly related to the discrepancy between prosthetic valve and straight vascular prosthesis diameters (p = 0.024), while there is not significant difference (log-rank = 0.917) related to aortic valve surgery type (replacement or repair). Considering diameter difference (DD) between vascular and aortic valve prosthesis, patients were subsequently grouped into two sections: L5 group, in which DD was less/equal than 5 mm, and M5, in which DD was more/equal than 5 mm. ARE was found in 30.8 % of L5 patients and only in 14.7 % among M5 patients (log-rank = 0.026). We have also observed descending thoracic aorta dilatation in 34.2 % of L5 and in 12.1 % of M5 (log-rank = 0.023). <strong>Conclusions</strong>: According with our data, difference between vascular prosthesis and aortic valve prosthesis equal/more than 5 mm is a protective factor against ARE and DATD.</p> Francesca D’Auria, Danilo Flavio Santo Copyright (c) 2023 Global Journal of Cardiovascular Diseases Fri, 27 Oct 2023 00:00:00 +0000