Online Journal of Microbiological Research https://www.scipublications.com/journal/index.php/ojmr <p>Online Journal of Microbiological Research (OJMR) is an international journal dedicated to the latest advancements in Microbiology. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Microbiology.</p> en-US Online Journal of Microbiological Research Drug-Receptor Interaction of Peptidic HIV-1 Protease: Polar Effect-II https://www.scipublications.com/journal/index.php/ojmr/article/view/414 <p>Klopman described the chemical reaction of metal ions and base ions in term of softness, E<sup>‡</sup><sub>n</sub> and E<sup>‡</sup><sub>m</sub>, respectively. By simple modification of known methods, Singh et al. made it applicable for neutral Lewis acids (transition metal salts) and bases (organic molecules) and also extended its application to biological systems for site selectivity and to explain reaction mechanism (markovnikov and anti-markovnikov rule), ligand-receptor interaction of testosterones, estrogens and tetrahydroimidazobenzodiazepinone. In this study effective atomic softness E<sup>‡</sup><sub>n(eff)</sub> and E<sup>‡</sup><sub>m(eff)</sub>, and their change ΔE<sup>‡</sup><sub>nm</sub> have been used for site selectivity and polar interaction between 51 peptidic HIV-1 protease inhibitors and receptor amino acids. ΔE<sup>‡</sup><sub>nm</sub> values derived from drug-receptor interaction show that when one moiety on receptor behaves as nucleophile (O of valine amino acid) at the same time maximum electrophilic site of the drug (C-atom of the maximum E<sup>‡</sup><sub>n(eff) </sub>value) orient itself to come close the respective site and make maximum interaction, while when another moiety on receptor behaves as electrophilic site (C of isoleucine amino acid), at the same time maximum nucleophilic site of the drug (O-atom of the maximum E<sup>‡</sup><sub>m(eff) </sub>value) also orient itself to come close the respective site and make maximum interaction.</p> Vishnu Kumar Sahu Rajesh Kumar Singh Pashupati Prasad Singh Copyright (c) 2022 Online Journal of Microbiological Research 2022-09-20 2022-09-20 1 11