World Journal of Clinical Medicine Research

Journal profile

World Journal of Clinical Medicine Research(WJCMR) is a peer reviewed journal dedicated to the latest advancement of clinical medicine. The goal of this journal is to serve as a resource for dissemination of state-of-the-art research and educational material within the field of clinical medicine. CMR aims to promote rapid communication and dialogue among researchers, scientists, and engineers working in the areas of clinical medicine. It is hoped that this journal will prove to be an important factor in raising the standards of discussion, analyses, and evaluations relating to clinical medicine programs.

Latest Articles

Open Access April 24, 2024 Endnote/Zotero/Mendeley (RIS) BibTeX

Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

World Journal of Clinical Medicine Research 2024, 4(1), 7-22. DOI: 10.31586/wjcmr.2024.914
Abstract
Delirium is a major complication most commonly observed in patients with advanced cancer. However, despite its prevalence, the early diagnosis, management, and prevention of this condition have not seen significant progress. Aim of this research is to provide insights into the prevalence of delirium, the optimization of interventions for managing
[...] Read more.
Delirium is a major complication most commonly observed in patients with advanced cancer. However, despite its prevalence, the early diagnosis, management, and prevention of this condition have not seen significant progress. Aim of this research is to provide insights into the prevalence of delirium, the optimization of interventions for managing delirium symptoms, their effectiveness and the impact of underlying factors on the reversibility of delirium in advanced cancer patients receiving palliative care. The review involved systematic searches of relevant databases including MEDLINE, CINAHL, ProQuest Nursing and Allied Health, and PsychInfo using refined search terms. Eight publications out of 614 studies originally searched were selected and critically reviewed. Their quality was assessed using Joanna Briggs Institute's Critical Appraisal Tool for Case Series. Data abstraction and content analysis were performed to synthesize the findings. Delirium is prevalent among advanced cancer patients in palliative care, with rates ranging from 10.3% to 24.1%. Pharmacotherapy and non-pharmacological interventions showed effectiveness in reducing delirium symptoms. Delirium was found to be reversible through palliative care interventions, antipsychotic medications, and exercise therapy. Effective delirium management is crucial in improving the quality of life of cancer patients. This review emphasizes the importance of subtype-specific treatments, standardized guidelines, and long-term follow-up studies. Implementing evidence-based individualized approaches to delirium management can optimize treatment efficacy and clinical outcomes in patients as well as improve the quality of care. Tailored interventions, standardized protocols, and further research are hereby recommended.Full article
Figures
Review Article
Open Access March 5, 2024 Endnote/Zotero/Mendeley (RIS) BibTeX

The Future of Digital Drug Traceability in the Global Supply Chain

World Journal of Clinical Medicine Research 2024, 4(1), 1-6. DOI: 10.31586/wjcmr.2024.896
Abstract
The digital drug traceability systems ensure the patient-centric dose, dosage form, and strength delivered to the patient as intended in the supply chain. It helps the digital healthcare platforms securely establish drug information supplied to patients for potential treatments. Therefore, it is important for the global supply chain to explore
[...] Read more.
The digital drug traceability systems ensure the patient-centric dose, dosage form, and strength delivered to the patient as intended in the supply chain. It helps the digital healthcare platforms securely establish drug information supplied to patients for potential treatments. Therefore, it is important for the global supply chain to explore the number of high-end digital health solutions and drug traceability to create an interactive loop on drug security for patients. This article provides an overview of advanced technologies for digital drug traceability, such as blockchain, that would establish a secure pharmaceutical supply chain for the digital world.Full article
Figures
Review Article
Open Access November 20, 2023 Endnote/Zotero/Mendeley (RIS) BibTeX

Ensitrelvir improved SARS-CoV-2 viral titers of COVID-19 patients refractory to remdesivir

World Journal of Clinical Medicine Research 2023, 3(1), 27-31. DOI: 10.31586/wjcmr.2023.796
Abstract
Background: The titers of SARS-COV-2 antigens are frequently used as markers of viral activity and threshold for release from quarantine and treatment. COVID-19 patients were treated with several antiviral agents, including remdesivir (RDV) and ensitrelvir (ESV), which is a novel anti-SARS-CoV-2 agent recently suggested to have strong antiviral activity. Cases:
[...] Read more.
Background: The titers of SARS-COV-2 antigens are frequently used as markers of viral activity and threshold for release from quarantine and treatment. COVID-19 patients were treated with several antiviral agents, including remdesivir (RDV) and ensitrelvir (ESV), which is a novel anti-SARS-CoV-2 agent recently suggested to have strong antiviral activity. Cases: We present the cases of two patients whose SARS-CoV-2 antigens were successfully decreased by oral administration of ESV after they could not be decreased by RDV drip infusion. Case 1 was a 74-year-old man who was admitted with SARS-CoV-2 infection and had been infected by the virus a month earlier and relapsed twice. He had been treated with rituximab for diffuse B cell lymphoma and not received vaccination for SARS-CoV-2. RDV was administered intravenously two weeks earlier and again 4 days earlier, but it failed to control the infection, and he was transferred to our hospital (day 1). Intravenous RDV was restarted on day 1, but viral antigens remained high until day 5. The RDV was then switched to oral ESV, and viral antigen titers were successfully decreased on days 8, 10, and 12. Case 2 was an 81-year-old man who was admitted with SARS-CoV-2 infection on day 0. He had heart failure and diabetes mellitus, and had not received vaccination for SARS-CoV-2. Intravenous RDV was started on day 1, but viral antigens were still high until day 8. He was then switched from RDV to oral ESV, and viral antigen titers were successfully decreased on day 11. Conclusions: These cases suggest that ESV might be more effective than RDV for reducing viral activity, and it is easy to administer orally.Full article
Figures
Case Series
Open Access October 8, 2023 Endnote/Zotero/Mendeley (RIS) BibTeX

Correlation of Thyroid Gland Functions with Menstrual Patterns amongst Infertile and Fertile Women Attending a Tertiary Care Hospital in North-Central Nigeria

World Journal of Clinical Medicine Research 2023, 3(1), 13-26. DOI: 10.31586/wjcmr.2023.787
Abstract
A regular menstrual cycle is important to maintain a woman’s fertility. This cycle has been linked to optimal function of the thyroid gland in the production of its hormones. Disturbance of thyroid gland functions could result to female infertility due to changes in menstrual patterns. Aim of this research was
[...] Read more.
A regular menstrual cycle is important to maintain a woman’s fertility. This cycle has been linked to optimal function of the thyroid gland in the production of its hormones. Disturbance of thyroid gland functions could result to female infertility due to changes in menstrual patterns. Aim of this research was to determine the correlation between thyroid gland functions and menstrual patterns amongst infertile and fertile women attending a tertiary care hospital in North-Central Nigeria. This comparative, cross-sectional study recruited 106 women who visited the hospital's Gynecology Clinic and Family Planning Clinic. 53 of the 106 patients were women with a history suggestive of either primary or secondary infertility and the remaining 53 women with no history of infertility served as the control. A well-structured questionnaire was used to obtain data on the patients’ menstrual patterns. Anthropometric data were measured and obtained. Collected blood samples were analyzed using Enzyme-Linked Immunosorbent Assay (ELISA) technique to determine the serum levels of thyroid hormones. All obtained data was analyzed, and the level of significance was set at p<0.05, at a 95% confidence interval. 33 patients had menstrual anomalies (78.8% infertile women; 21.2% fertile women who served as control, p=0.012). The incidence of menstrual anomalies in the infertile women group and control group was 7.5% versus 0.0% for amenorrhea; 20.8% versus 5.7% for menorrhagia; 9.4% versus 7.5% for oligomenorrhea; 7.5% versus 0.0% for hypomenorrhea; nil polymenorrhea for both groups; and 50.9% versus 86.8% for normal menstrual patterns. Ten (9.43%) patients were diagnosed with thyroid dysfunctions (80% in infertile group; 20% in control group, p=0.046). Six (18.2%) out of 33 women with menstrual anomalies were diagnosed with thyroid dysfunction. Five (83.3%) out of these 6 women with both menstrual anomalies and diagnosed thyroid dysfunction were infertile while only one (16.7%) was fertile. Thyroid gland dysfunction correlates strongly with abnormal menstrual patterns, which implies that it is vital to evaluate thyroid hormone levels in blood serum in the course of treating menstrual irregularities and female infertility. Early detection of thyroid dysfunction is important in achieving a positive treatment outcome for female infertility.Full article
Figures
Article
Open Access January 6, 2023 Endnote/Zotero/Mendeley (RIS) BibTeX

Retinal Detachment: A Mini Review

World Journal of Clinical Medicine Research 2023, 3(1), 1-12. DOI: 10.31586/wjcmr.2023.575
Abstract
Retinal detachments comprised of serious ocular conditions and can lead to permanent vision loss. When the retina, the neurosensory layer, detaches from the back of the eye, it loses its oxygen and nutrient supply leading to the death of the tissue. Immediate diagnosis and treatment are essential to avoid significant
[...] Read more.
Retinal detachments comprised of serious ocular conditions and can lead to permanent vision loss. When the retina, the neurosensory layer, detaches from the back of the eye, it loses its oxygen and nutrient supply leading to the death of the tissue. Immediate diagnosis and treatment are essential to avoid significant morbidity associated with this condition. In this mini review, we outline the evaluation and management of retinal detachments and highlights the role of the interprofessional team in evaluating and treating patients with this condition.Full article
Figures
Mini Review
Open Access November 21, 2022 Endnote/Zotero/Mendeley (RIS) BibTeX

Impact of Lesion Locations on the Severity of Post-Stroke Depression

World Journal of Clinical Medicine Research 2022, 2(1), 22-26. DOI: 10.31586/wjcmr.2022.505
Abstract
Background: Depression occurs in one-third of stroke patients, in what is known as post-stroke depression. The lesion sites in stroke have been associated with the degree of depression. However, studies have provided different perspectives, and this necessitates further clarification. This study investigates the relationship between the lesion sites and the
[...] Read more.
Background: Depression occurs in one-third of stroke patients, in what is known as post-stroke depression. The lesion sites in stroke have been associated with the degree of depression. However, studies have provided different perspectives, and this necessitates further clarification. This study investigates the relationship between the lesion sites and the severity of depression in ischemic stroke patients. Methods: This cross-sectional study was conducted between January and April 2020. All samples were obtained from admitted patients with ischemic stroke who agreed to participate in the study. Data were collected using Beck’s Depression Inventory-II (BDI-II), which was used to determine the severity of depression, and the lesion sites were based on radiological imaging interpretation. Results: The study showed a significant association between the lesion site and the degree of depression (OR = 5,368, p-value = 0,013). Lesions in the frontal lobe demonstrated stronger associations with the severity of depression. Conclusion: The location of the lesion, especially in the frontal lobe, was associated with more severe post-stroke depression.Full article
Case Study
Open Access October 15, 2022 Endnote/Zotero/Mendeley (RIS) BibTeX

Cyclophosphamide Induces Hepatorenal Toxicity and Attenuation by 5-fluorouracil in Male Albino Rats

World Journal of Clinical Medicine Research 2022, 2(1), 8-21. DOI: 10.31586/wjcmr.2022.455
Abstract
Background: Cyclophosphamide (CPA) induces acute inflammation of the urinary bladder, renal damage, and liver damage, thereby limiting its therapeutic use. Objectives: The present study aimed to evaluate the hepatorenal toxicity induced by cyclophosphamide and amelioration by 5-fluorouracil in male albino rats. Materials and Methods: Twenty-eight male adult rats were grouped
[...] Read more.
Background: Cyclophosphamide (CPA) induces acute inflammation of the urinary bladder, renal damage, and liver damage, thereby limiting its therapeutic use. Objectives: The present study aimed to evaluate the hepatorenal toxicity induced by cyclophosphamide and amelioration by 5-fluorouracil in male albino rats. Materials and Methods: Twenty-eight male adult rats were grouped randomly into four groups (n=5 for each group). Group I (control): Rats were injected with saline intraperitoneally and at a dose of 1.0 ml/kg b.w. for 14 days. Group II cyclophosphamide (CPA): Cyclophosphamide at a dose of 10 mg/kg day by day through i.p. to rats for 14 days. Group III Fluorouracil (5-FU): 5-Fluorouracil at a dose of 10 mg/kg day by day in saline was given through i.p. to rats for 14 days. Group IV (CPA+5-FU): Rats were given CPA followed by 5-FU at a dose of 10 mg/kg per day (day by day) through i.p. to rats for 14 days. At the end of the experimental period, rats were anesthetized using light ether. Blood samples were taken and prepared for biochemical measurements. Results: Serum total protein, albumin, and globulin concentration significantly reduced in animal groups that received cyclophosphamide. 5-FU and CPA combination reduced the changes in total protein, albumin, and globulin compared to CPA treated group. A significant increase in LDH serum concentration was found in CPA, 5-FU, and their combination-treated animals. The mean values of the combination of chemotherapy were above that in CPA followed by 5-FU treatment. Administration of CPA, 5-FU resulted in a significant increase in serum AST, ALT, ALP, and bilirubin compared to the control. Co-treatment 5-FU with CPA significantly attenuated the increase in serum AST, ALT, ALP, and bilirubin when compared to CPA – treated rats. Compared to controls, urea and creatinine levels were increased in CPA-treated rats, while uric acid was reduced in CPA, 5-FU, and their combination. The changes in urea and creatinine produced by the chemotherapy were restored when rats received CPA in combination with 5-FU. Conclusion: It could be concluded that the treatment of mammals with chemotherapy is associated with the production of free radicals that lead to hazardous alterations in biochemical parameters. However, 5-FU and CPA combination could produce a significant amelioration in most cases for these changes, and it may be considered as a potentially useful candidate in the combination chemotherapy with CPA to combat oxidative stress-mediated non-target organ injury even if it was not complete protection. Future work should consider combined chemotherapy regimens, as two or more mechanisms of action of chemotherapeutic drugs could be more powerful than one mechanism. Toxicological studies must be performed before using drugs as a combination before application. Further research is required on the toxicological impacts of drugs and pollutants mixtures.Full article
Figures
Article
Open Access October 12, 2022 Endnote/Zotero/Mendeley (RIS) BibTeX

Acceptance of a Prescription for Smoking Cessation Utilizing an iPad Educational Application

World Journal of Clinical Medicine Research 2022, 2(1), 1-7. DOI: 10.31586/wjcmr.2022.444
Abstract
Tobacco use, especially smoking, poses an enormous threat to public health. Research indicates tobacco use is linked to many illnesses and premature death. It also has unhealthy consequences in non-smokers through second-hand exposure. Primary care clinicians have the “golden opportunities” to intervene during office visit encounters. This study examined the
[...] Read more.
Tobacco use, especially smoking, poses an enormous threat to public health. Research indicates tobacco use is linked to many illnesses and premature death. It also has unhealthy consequences in non-smokers through second-hand exposure. Primary care clinicians have the “golden opportunities” to intervene during office visit encounters. This study examined the use of an iPad educational application in tobacco cessation counseling that would increase acceptance of a prescription to aid with cessation, compared to the traditional method of counseling only. Utilizing smoking cessation guidelines, a descriptive quantitative exploratory methodology was used in two phases to assess the effectiveness of tobacco cessation education in a traditional verbal counseling versus the additional use of a mobile application along with standard tobacco cessation counseling in a primary care clinical setting. Total of 49 participants were recruited in two different groups. The standard cessation counseling had 29 subjects for Phase I and 20 participants in the enhanced tobacco cessation education group in Phase II. The enhanced tobacco cessation education with an iPad was more effective in smoking education than the traditional standard verbal counseling on smoking cessation. The addition of a mobile device with relevant educational materials shared with smokers by clinicians have shown an increase in acceptance of a prescription to aid tobacco cessation. Clinicians are strongly encouraged to find innovative ways to help smoking patients accept aids in successful cessation attempts.Full article
Article
Open Access September 10, 2022 Endnote/Zotero/Mendeley (RIS) BibTeX

General Health, Fatigue and Social Support among Health Professionals: The Contribution of Sociodemographic and Occupational Variables

World Journal of Clinical Medicine Research 2022, 1(1), 28-37. DOI: 10.31586/wjcmr.2022.419
Abstract
Health professionals are the base of the healthcare systems in all societies. Their daily contact with the patient in a context of demanding and difficult working conditions affect their general health. This research was carried out to describe the levels of general health among health professionals and their perceived levels
[...] Read more.
Health professionals are the base of the healthcare systems in all societies. Their daily contact with the patient in a context of demanding and difficult working conditions affect their general health. This research was carried out to describe the levels of general health among health professionals and their perceived levels of fatigue and social support. Additionally, the purpose of this study was to examine the above three variables in relation to demographic (education, gender) and employment factors (working hours, department). The research was conducted in 165 health professionals working in hospitals in the region of Eastern Macedonia-Thrace and in the urban centers of Athens and Thessaloniki. The General Health Questionnaire (GHQ-28), the Fatigue Assessment Scale (FAS) as well as the Multidimensional Scale of Perceived Social Support (MSPSS) were used to measure the research variables. The processing and statistical analysis of the data was done using IBM SPSS. The majority of health professionals presented a high score in GHQ-28 subscales indicating low general health (avg 8.59≥5). One hundred thirty nine out of 165 health professionals (84%) were tired and 15 out of 165 (9%) were too tired. The perceived social support was at high levels (avg 5.57). Health professionals exhibit high fatigue and low levels of general health and quality of life. Instead, they receive high social support. Existence of circular hours and work in heavy part worsens the levels of fatigue and quality of life. Measures are needed to increase the number of health professionals and organizational and structural measures to improve their working conditions and strengthen their social work.Full article
Article
Open Access September 4, 2022 Endnote/Zotero/Mendeley (RIS) BibTeX

The Effect of Parent School Counseling Programs on Anxiety, Depression and Quality of Life

World Journal of Clinical Medicine Research 2022, 1(1), 18-27. DOI: 10.31586/wjcmr.2022.404
Abstract
Parental anxiety and depression are factors that significantly affect the practice of parental role and have an impact on the upbringing of children and their quality of life. The purpose of this study is to investigate whether the counseling intervention that parents received during their participation in parent school programs
[...] Read more.
Parental anxiety and depression are factors that significantly affect the practice of parental role and have an impact on the upbringing of children and their quality of life. The purpose of this study is to investigate whether the counseling intervention that parents received during their participation in parent school programs reduced stress and depressive symptoms and improved their quality of life. A sample of 160 parents was collected from two independent groups: the experimental group consisting of 80 parents who participated in the program and the control group consisting of parents who after being informed about the implementation of the programs in their schools decided not to participate. The psychometric tools have been used are: The Spielberger Stress Trait Anxiety Inventory (STAI), the Beck depression Inventory (BDI), and the Health and well-being Questionnaire (The RAND 36-Item Healthy Survey, SF-36, Version 1.0). The results of the research confirmed the research hypothesis according to which the effect of the counseling intervention on the parents who participated in the parent schools affected the reduction of the stress index, state anxiety (Ζ=-2,882, p=0,004) and trait anxiety (Ζ=-3,776, p<0,001), the reduction of the depression index (Ζ=-6,876, p<0,001) and the improvement of their quality of life(Ζ=-5,364, p<0,001) ) especially of physical health (Ζ=-4,529, p<0,001) and emotional health (Ζ=-4,529, p<0,001).Full article
Article

Views of

Downloads of

Citations of

ISSN: 2834-3158
DOI prefix: 10.31586/wjcmr
Journal metrics
Publication year
2021-2024
Journal (home page) visits
7145
Article views
22113
Article downloads
9419
Downloads/article
724.54
APC
99.00