@Article{crph1250,
AUTHOR = {Assari, Shervin and Donovan, Alexandra and Najand, Babak and Akhlaghipour, Golnoush and Mendez, Mario F},
TITLE = {Hippocampus Functional Connectivity, Impulsivity, and Subsequent Substance Use},
JOURNAL = {Current Research in Public Health},
VOLUME = {2},
YEAR = {2025},
NUMBER = {1},
PAGES = {23-30},
URL = {https://www.scipublications.com/journal/index.php/JCN/article/view/1250},
ISSN = {2831-5162},
DOI = {10.31586/jcn.2025.1250},
ABSTRACT = {Background: The hippocampus plays a critical role in memory and decision-making processes, with its resting-state functional connectivity (rsFC) linked to various behavioral outcomes. This study investigates whether baseline brain-wide rsFC of the hippocampus mediates the relationship between impulsivity and subsequent substance use, specifically tobacco and marijuana use, in adolescents. Methods: Data were drawn from the baseline wave of the Adolescent Brain Cognitive Development (ABCD) study. Resting-state fMRI data were used to evaluate the functional connectivity of the hippocampus with key brain networks, including the cingulo-parietal network, visual network, sensory-motor network, and default mode network (DMN). Impulsivity was assessed using validated self-report measures, and substance use (tobacco and marijuana) was evaluated at follow-up. Mediation models were conducted to examine the extent to which hippocampal rsFC explains the association between impulsivity and substance use. Results: Baseline hippocampal rsFC with the cingulo-parietal network, visual network, sensory-motor network, and DMN showed marginal associations with future tobacco and marijuana use. Additionally, hippocampal rsFC was significantly associated with impulsivity, which, in turn, predicted higher substance use at follow-up. These findings suggest that hippocampal rsFC partially mediates the relationship between impulsivity and substance use behaviors. Conclusions: Hippocampal functional connectivity with brain networks may influence the pathway from impulsivity to future substance use in adolescence. These findings emphasize the importance of hippocampal connectivity in understanding the neural mechanisms underlying risk behaviors and may inform the development of targeted interventions to reduce substance use in this vulnerable population.},
}

%0 Journal Article
%A Assari, Shervin
%A Donovan, Alexandra
%A Najand, Babak
%A Akhlaghipour, Golnoush
%A Mendez, Mario F
%D 2025
%J Current Research in Public Health

%@ 2831-5162
%V 2
%N 1
%P 23-30

%T Hippocampus Functional Connectivity, Impulsivity, and Subsequent Substance Use
%M doi:10.31586/jcn.2025.1250
%U https://www.scipublications.com/journal/index.php/JCN/article/view/1250

TY  - JOUR
AU  - Assari, Shervin
AU  - Donovan, Alexandra
AU  - Najand, Babak
AU  - Akhlaghipour, Golnoush
AU  - Mendez, Mario F
TI  - Hippocampus Functional Connectivity, Impulsivity, and Subsequent Substance Use
T2  - Current Research in Public Health
PY  - 2025
VL  - 2
IS  - 1
SN  - 2831-5162
SP  - 23
EP  - 30
UR  - https://www.scipublications.com/journal/index.php/JCN/article/view/1250
AB  - Background: The hippocampus plays a critical role in memory and decision-making processes, with its resting-state functional connectivity (rsFC) linked to various behavioral outcomes. This study investigates whether baseline brain-wide rsFC of the hippocampus mediates the relationship between impulsivity and subsequent substance use, specifically tobacco and marijuana use, in adolescents. Methods: Data were drawn from the baseline wave of the Adolescent Brain Cognitive Development (ABCD) study. Resting-state fMRI data were used to evaluate the functional connectivity of the hippocampus with key brain networks, including the cingulo-parietal network, visual network, sensory-motor network, and default mode network (DMN). Impulsivity was assessed using validated self-report measures, and substance use (tobacco and marijuana) was evaluated at follow-up. Mediation models were conducted to examine the extent to which hippocampal rsFC explains the association between impulsivity and substance use. Results: Baseline hippocampal rsFC with the cingulo-parietal network, visual network, sensory-motor network, and DMN showed marginal associations with future tobacco and marijuana use. Additionally, hippocampal rsFC was significantly associated with impulsivity, which, in turn, predicted higher substance use at follow-up. These findings suggest that hippocampal rsFC partially mediates the relationship between impulsivity and substance use behaviors. Conclusions: Hippocampal functional connectivity with brain networks may influence the pathway from impulsivity to future substance use in adolescence. These findings emphasize the importance of hippocampal connectivity in understanding the neural mechanisms underlying risk behaviors and may inform the development of targeted interventions to reduce substance use in this vulnerable population.
DO  - Hippocampus Functional Connectivity, Impulsivity, and Subsequent Substance Use
TI  - 10.31586/jcn.2025.1250
ER  -