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Communication Open Access October 22, 2021

PTEN May Involve in Regulation of PD-L1 Expression in Triple Negative Breast Carcinoma

Kit Cheng Wai 1, Kin Iong Chan 1, Hong Ting Vong 1, Xue Yun Zhong 2 and Jian Ming Wen 1,*
1
Department of Pathology, Kiang Wu Hospital, Macao Special Administrative Region, China.
2
Department of Pathology, Medical School of Jinan University, Guangzhou, China.
Publihed in: Current Research in Public Health (Volume 1, Issue 1, 2021)
Page(s): 45-52
DOI: 10.31586/ojms.2021.157
Received
September 20, 2021
Revised
October 20, 2021
Accepted
October 21, 2021
Published
October 22, 2021
Keywords
Triple Negative Breast Carcinoma; PD-L1; PTEN; Gene Regulation
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2021. Published by Scientific Publications
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Cite This Article

APA Style
Wai, K. C. , Wai, K. C. Chan, K. I. , Chan, K. I. Vong, H. T. , Vong, H. T. Zhong, X. Y. , & Zhong, X. Y. (2021). PTEN May Involve in Regulation of PD-L1 Expression in Triple Negative Breast Carcinoma. Current Research in Public Health, 1(1), 45-52. https://doi.org/10.31586/ojms.2021.157
ACS Style
Wai, K. C. ; Wai, K. C. Chan, K. I. ; Chan, K. I. Vong, H. T. ; Vong, H. T. Zhong, X. Y. ; Zhong, X. Y. PTEN May Involve in Regulation of PD-L1 Expression in Triple Negative Breast Carcinoma. Current Research in Public Health 2021 1(1), 45-52. https://doi.org/10.31586/ojms.2021.157
Chicago/Turabian Style
Wai, Kit Cheng, Kit Cheng Wai. Kin Iong Chan, Kin Iong Chan. Hong Ting Vong, Hong Ting Vong. Xue Yun Zhong, and Xue Yun Zhong. 2021. "PTEN May Involve in Regulation of PD-L1 Expression in Triple Negative Breast Carcinoma". Current Research in Public Health 1, no. 1: 45-52. https://doi.org/10.31586/ojms.2021.157
AMA Style
Wai KC, Wai KCChan KI, Chan KIVong HT, Vong HTZhong XY, Zhong XY. PTEN May Involve in Regulation of PD-L1 Expression in Triple Negative Breast Carcinoma. Current Research in Public Health. 2021; 1(1):45-52. https://doi.org/10.31586/ojms.2021.157 
@Article{crph157,
AUTHOR = {Wai, Kit Cheng and Chan, Kin Iong and Vong, Hong Ting and Zhong, Xue Yun and Wen, Jian Ming},
TITLE = {PTEN May Involve in Regulation of PD-L1 Expression in Triple Negative Breast Carcinoma},
JOURNAL = {Current Research in Public Health},
VOLUME = {1},
YEAR = {2021},
NUMBER = {1},
PAGES = {45-52},
URL = {/10.31586/ojms-1-1-610.31586/ojms/1/1/6},
ISSN = {2831-5162},
DOI = {10.31586/ojms.2021.157},
ABSTRACT = {Triple negative breast carcinoma (TNBC) is a rapid progressive tumor and has a poor overall survival. Therefore, it is crucial to find out effective molecular targets and develop optimal therapeutic strategies for TNBC. In this study, immunohistochemical staining was used to detect expressions of programmed death-ligand 1 (PD-L1) and phosphatase and tensin homolog (PTEN) in 136 breast carcinomas including 50 TNBC. The effect of PTEN on regulation of PD-L1 expression was assessed in vitro in the PTEN knockdown TNBC cells. We found that PD-L1(SP142) positive rate in TNBC (48.0%) was significantly higher than non-TNBC (23.3%). PTEN negative rate was 42% in TNBC. The inverse correlation between PTEN and PD-L1(SP142) expression in TNBC was statistically significant (P<0.05). After PTEN knockdown, PD-L1 expression in TNBC cells increased significantly, and the expression level of AKT increased simultaneously. PTEN knockdown promoted cell proliferation, viability and G1/S switch of TNBC cells. These results suggested that PTEN may involve in regulation of PD-L1 expression, because PTEN loss can upregulate PD-L1 expression in TNBC. Antitumor immunity of PD-L1 could be enhanced in TNBC when targeting PTEN at the same time.},
}
%0 Journal Article
%A Wai, Kit Cheng
%A Chan, Kin Iong
%A Vong, Hong Ting
%A Zhong, Xue Yun
%A Wen, Jian Ming
%D 2021
%J Current Research in Public Health

%@ 2831-5162
%V 1
%N 1
%P 45-52

%T PTEN May Involve in Regulation of PD-L1 Expression in Triple Negative Breast Carcinoma
%M doi:10.31586/ojms.2021.157
%U /10.31586/ojms-1-1-610.31586/ojms/1/1/6

TY  - JOUR
AU  - Wai, Kit Cheng
AU  - Chan, Kin Iong
AU  - Vong, Hong Ting
AU  - Zhong, Xue Yun
AU  - Wen, Jian Ming
TI  - PTEN May Involve in Regulation of PD-L1 Expression in Triple Negative Breast Carcinoma
T2  - Current Research in Public Health
PY  - 2021
VL  - 1
IS  - 1
SN  - 2831-5162
SP  - 45
EP  - 52
UR  - /10.31586/ojms-1-1-610.31586/ojms/1/1/6
AB  - Triple negative breast carcinoma (TNBC) is a rapid progressive tumor and has a poor overall survival. Therefore, it is crucial to find out effective molecular targets and develop optimal therapeutic strategies for TNBC. In this study, immunohistochemical staining was used to detect expressions of programmed death-ligand 1 (PD-L1) and phosphatase and tensin homolog (PTEN) in 136 breast carcinomas including 50 TNBC. The effect of PTEN on regulation of PD-L1 expression was assessed in vitro in the PTEN knockdown TNBC cells. We found that PD-L1(SP142) positive rate in TNBC (48.0%) was significantly higher than non-TNBC (23.3%). PTEN negative rate was 42% in TNBC. The inverse correlation between PTEN and PD-L1(SP142) expression in TNBC was statistically significant (P<0.05). After PTEN knockdown, PD-L1 expression in TNBC cells increased significantly, and the expression level of AKT increased simultaneously. PTEN knockdown promoted cell proliferation, viability and G1/S switch of TNBC cells. These results suggested that PTEN may involve in regulation of PD-L1 expression, because PTEN loss can upregulate PD-L1 expression in TNBC. Antitumor immunity of PD-L1 could be enhanced in TNBC when targeting PTEN at the same time.
DO  - PTEN May Involve in Regulation of PD-L1 Expression in Triple Negative Breast Carcinoma
TI  - 10.31586/ojms.2021.157
ER  -