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Review Article Open Access November 23, 2021

BDNF, A Focus to Major Depression

Aparecida Marcelino de Nazareth 1,*
1
Federal University of Rio de Janeiro (UFRJ), Rua Praia de Botafogo, 524/122, Rio de Janeiro, Brazil
Publihed in: Current Research in Public Health (Volume 1, Issue 1, 2021)
Page(s): 10-21
DOI: 10.31586/ojp.2021.161
Received
October 02, 2021
Revised
November 17, 2021
Accepted
November 22, 2021
Published
November 23, 2021
Keywords
Major depressive disorder; Brain-derived neurotrophic factor (BDNF); Serotonin; Antidepressive agents.
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2021. Published by Scientific Publications
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Cite This Article

APA Style
Nazareth, A. M. (2021). BDNF, A Focus to Major Depression. Current Research in Public Health, 1(1), 10-21. https://doi.org/10.31586/ojp.2021.161
ACS Style
Nazareth, A. M. BDNF, A Focus to Major Depression. Current Research in Public Health 2021 1(1), 10-21. https://doi.org/10.31586/ojp.2021.161
Chicago/Turabian Style
Nazareth, Aparecida Marcelino. 2021. "BDNF, A Focus to Major Depression". Current Research in Public Health 1, no. 1: 10-21. https://doi.org/10.31586/ojp.2021.161
AMA Style
Nazareth AM. BDNF, A Focus to Major Depression. Current Research in Public Health. 2021; 1(1):10-21. https://doi.org/10.31586/ojp.2021.161 
@Article{crph161,
AUTHOR = {Nazareth, Aparecida Marcelino},
TITLE = {BDNF, A Focus to Major Depression},
JOURNAL = {Current Research in Public Health},
VOLUME = {1},
YEAR = {2021},
NUMBER = {1},
PAGES = {10-21},
URL = {/10.31586/ojp-1-1-310.31586/ojp/1/1/3},
ISSN = {2831-5162},
DOI = {10.31586/ojp.2021.161},
ABSTRACT = {Major depressive disorder is characterized, among other symptoms, by depressed mood and anhedonia associated with a high rate of suicidal ideation. In recent years, research has shown reduced expression of the brain-derived neurotrophic factor (BDNF) in limbic areas of individuals with depression. This reduction of BDNF is reversed by antidepressants in animal models of stress. Stress is one of the main triggers of mood disorders such as depression. Also, administration of BDNF increases the number of serotonergic fibers and serotonergic innervation, indicating an increase of serotonin in the synaptic cleft by this neurotrophin. Thus, BDNF appears to be one of the targets of antidepressant drugs for the increase of monoamines and remission of symptoms of major depression. The purpose of this review was to show the evidence that indicates BDNF as a molecular substrate for vulnerability to depression and the response of this substrate to the antidepressants.},
}
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AB  - Major depressive disorder is characterized, among other symptoms, by depressed mood and anhedonia associated with a high rate of suicidal ideation. In recent years, research has shown reduced expression of the brain-derived neurotrophic factor (BDNF) in limbic areas of individuals with depression. This reduction of BDNF is reversed by antidepressants in animal models of stress. Stress is one of the main triggers of mood disorders such as depression. Also, administration of BDNF increases the number of serotonergic fibers and serotonergic innervation, indicating an increase of serotonin in the synaptic cleft by this neurotrophin. Thus, BDNF appears to be one of the targets of antidepressant drugs for the increase of monoamines and remission of symptoms of major depression. The purpose of this review was to show the evidence that indicates BDNF as a molecular substrate for vulnerability to depression and the response of this substrate to the antidepressants.
DO  - BDNF, A Focus to Major Depression
TI  - 10.31586/ojp.2021.161
ER  -