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Mini Review Open Access December 16, 2021

Role of Colchicine in Management of COVID-19?

Kholoud Mohamed Elawady Elhefnawy Elshiwy 1, Ghada Essam El-Din Amin 1, 2, Mohamed Nazmy 3, Rasha Samir 3 and Mohamed Farouk Allam 1, 4,*
1
Department of Family Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2
Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3
Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4
Department of Preventive Medicine and Public Health, School of Medicine, University of Cordoba, Cordoba 14004, Spain
Publihed in: Current Research in Public Health (Volume 2, Issue 1, 2022)
Page(s): 1-3
DOI: 10.31586/gjeid.2022.177
Received
November 09, 2021
Revised
December 10, 2021
Accepted
December 15, 2021
Published
December 16, 2021
Keywords
Coronavirus; COVID-19; Colchicine; Management; Review
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2022. Published by Scientific Publications
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Cite This Article

APA Style
Elshiwy, K. M. E. E. , Elshiwy, K. M. E. E. Amin, G. E. E. , Amin, G. E. E. Nazmy, M. , Nazmy, M. Samir, R. , & Samir, R. (2022). Role of Colchicine in Management of COVID-19?. Current Research in Public Health, 2(1), 1-3. https://doi.org/10.31586/gjeid.2022.177
ACS Style
Elshiwy, K. M. E. E. ; Elshiwy, K. M. E. E. Amin, G. E. E. ; Amin, G. E. E. Nazmy, M. ; Nazmy, M. Samir, R. ; Samir, R. Role of Colchicine in Management of COVID-19?. Current Research in Public Health 2022 2(1), 1-3. https://doi.org/10.31586/gjeid.2022.177
Chicago/Turabian Style
Elshiwy, Kholoud Mohamed Elawady Elhefnawy, Kholoud Mohamed Elawady Elhefnawy Elshiwy. Ghada Essam El-Din Amin, Ghada Essam El-Din Amin. Mohamed Nazmy, Mohamed Nazmy. Rasha Samir, and Rasha Samir. 2022. "Role of Colchicine in Management of COVID-19?". Current Research in Public Health 2, no. 1: 1-3. https://doi.org/10.31586/gjeid.2022.177
AMA Style
Elshiwy KMEE, Elshiwy KMEEAmin GEE, Amin GEENazmy M, Nazmy MSamir R, Samir R. Role of Colchicine in Management of COVID-19?. Current Research in Public Health. 2022; 2(1):1-3. https://doi.org/10.31586/gjeid.2022.177 
@Article{crph177,
AUTHOR = {Elshiwy, Kholoud Mohamed Elawady Elhefnawy and Amin, Ghada Essam El-Din and Nazmy, Mohamed and Samir, Rasha and Allam, Mohamed Farouk},
TITLE = {Role of Colchicine in Management of COVID-19?},
JOURNAL = {Current Research in Public Health},
VOLUME = {2},
YEAR = {2022},
NUMBER = {1},
PAGES = {1-3},
URL = {/2770-867510.31586/gjeid-2-1-110.31586/gjeid/2/1/1},
ISSN = {2831-5162},
DOI = {10.31586/gjeid.2022.177},
ABSTRACT = {CoV-2 disease 2019 (COVID-19) pandemic has exerted a great burden on the health and economic systems worldwide. One of the most important factors that affect the severity and prognosis of COVID-19 is the occurrence of hyperstimulation of the immune system resulting in “cytokine storm”. Similar to SARS-CoV, an intracellular complex called nod like receptor family pyrin domain containing 3 (NLRP3) inflammasome was found to be activated by SARS-CoV-2, then in turn stimulates several interleukins and initiates the inflammatory cascade. In addition, other inflammatory mediators such as interferons e.g., IFN-α, and IFN-γ, interleukins e.g., IL-1β, IL-12, IL-18, tumor necrosis factor-α (TNF- α), and chemokines e.g., CCL2, CXCL10 have been reported in severely ill patients. These mediators represent the corner stone in developing cytokine storm that results in uncontrolled systemic inflammatory reaction with subsequent acute respiratory distress syndrome (ARDS), multiple organ failure and eventually death. Based on its anti-inflammatory effects, colchicine has also gained attention to be utilized in the management of COVID-19 patient. Colchicine exerts its anti-inflammatory effect through inhibition of formation of microtubules which is considered an essential step in several cellular processes such as division, signalling, and migration. Also, colchicine affects the cytokine cascade by inhibiting IL-1β leading to reduction in neutrophils recruitment, free radicles production and inflammasome stimulation. This raises the concerns about the effectiveness of colchicine in COVID-19 treatment and the possibility of providing an improvement of the clinical course of the disease.},
}
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%A Elshiwy, Kholoud Mohamed Elawady Elhefnawy
%A Amin, Ghada Essam El-Din
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%A Samir, Rasha
%A Allam, Mohamed Farouk
%D 2022
%J Current Research in Public Health

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AU  - Samir, Rasha
AU  - Allam, Mohamed Farouk
TI  - Role of Colchicine in Management of COVID-19?
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AB  - CoV-2 disease 2019 (COVID-19) pandemic has exerted a great burden on the health and economic systems worldwide. One of the most important factors that affect the severity and prognosis of COVID-19 is the occurrence of hyperstimulation of the immune system resulting in “cytokine storm”. Similar to SARS-CoV, an intracellular complex called nod like receptor family pyrin domain containing 3 (NLRP3) inflammasome was found to be activated by SARS-CoV-2, then in turn stimulates several interleukins and initiates the inflammatory cascade. In addition, other inflammatory mediators such as interferons e.g., IFN-α, and IFN-γ, interleukins e.g., IL-1β, IL-12, IL-18, tumor necrosis factor-α (TNF- α), and chemokines e.g., CCL2, CXCL10 have been reported in severely ill patients. These mediators represent the corner stone in developing cytokine storm that results in uncontrolled systemic inflammatory reaction with subsequent acute respiratory distress syndrome (ARDS), multiple organ failure and eventually death. Based on its anti-inflammatory effects, colchicine has also gained attention to be utilized in the management of COVID-19 patient. Colchicine exerts its anti-inflammatory effect through inhibition of formation of microtubules which is considered an essential step in several cellular processes such as division, signalling, and migration. Also, colchicine affects the cytokine cascade by inhibiting IL-1β leading to reduction in neutrophils recruitment, free radicles production and inflammasome stimulation. This raises the concerns about the effectiveness of colchicine in COVID-19 treatment and the possibility of providing an improvement of the clinical course of the disease.
DO  - Role of Colchicine in Management of COVID-19?
TI  - 10.31586/gjeid.2022.177
ER  -