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Mini Review Open Access February 22, 2022

Melatonin could be used for Treatment of COVID-19?

Rehab Mohamed Ali Mohamed 1, Ghada Essam El-Din Amin 1, 2, Salwa Mostafa Mohammad Abdel Rahman 1, 3 and Mohamed Farouk Allam 1, 4,*
1
Department of Family Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2
Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3
Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4
Department of Preventive Medicine and Public Health, School of Medicine, University of Cordoba, Cordoba 14004, Spain
Publihed in: Current Research in Public Health (Volume 2, Issue 1, 2022)
Page(s): 19-22
DOI: 10.31586/gjeid.2022.188
Received
November 26, 2021
Revised
February 10, 2022
Accepted
February 21, 2022
Published
February 22, 2022
Keywords
Coronavirus; COVID-19; Melatonin; Management; Review.
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2022. Published by Scientific Publications
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Cite This Article

APA Style
Mohamed, R. M. A. , Mohamed, R. M. A. Amin, G. E. E. , Amin, G. E. E. Rahman, S. M. M. A. , & Rahman, S. M. M. A. (2022). Melatonin could be used for Treatment of COVID-19?. Current Research in Public Health, 2(1), 19-22. https://doi.org/10.31586/gjeid.2022.188
ACS Style
Mohamed, R. M. A. ; Mohamed, R. M. A. Amin, G. E. E. ; Amin, G. E. E. Rahman, S. M. M. A. ; Rahman, S. M. M. A. Melatonin could be used for Treatment of COVID-19?. Current Research in Public Health 2022 2(1), 19-22. https://doi.org/10.31586/gjeid.2022.188
Chicago/Turabian Style
Mohamed, Rehab Mohamed Ali, Rehab Mohamed Ali Mohamed. Ghada Essam El-Din Amin, Ghada Essam El-Din Amin. Salwa Mostafa Mohammad Abdel Rahman, and Salwa Mostafa Mohammad Abdel Rahman. 2022. "Melatonin could be used for Treatment of COVID-19?". Current Research in Public Health 2, no. 1: 19-22. https://doi.org/10.31586/gjeid.2022.188
AMA Style
Mohamed RMA, Mohamed RMAAmin GEE, Amin GEERahman SMMA, Rahman SMMA. Melatonin could be used for Treatment of COVID-19?. Current Research in Public Health. 2022; 2(1):19-22. https://doi.org/10.31586/gjeid.2022.188 
@Article{crph188,
AUTHOR = {Mohamed, Rehab Mohamed Ali and Amin, Ghada Essam El-Din and Rahman, Salwa Mostafa Mohammad Abdel and Allam, Mohamed Farouk},
TITLE = {Melatonin could be used for Treatment of COVID-19?},
JOURNAL = {Current Research in Public Health},
VOLUME = {2},
YEAR = {2022},
NUMBER = {1},
PAGES = {19-22},
URL = {/2770-867510.31586/gjeid-2-1-310.31586/gjeid/2/1/3},
ISSN = {2831-5162},
DOI = {10.31586/gjeid.2022.188},
ABSTRACT = {Coronaviruses (CoVs) are a broad family of potentially serious RNA viruses that are now causing an outbreak of respiratory disease known as CoV disease 2019 (COVID-19). Melatonin is a pineal hormone that is predominantly produced and released at night from the amino acid tryptophan. Melatonin and its metabolites are also important in immunomodulation, and they have antioxidative properties due to their capacity to scavenge reactive oxygen species both directly and indirectly. COVID-19 leads to changes of altered consciousness levels in about 15% of hospitalized patients, starting from somnolence to disorientation, delirium, stupor, and coma. Melatonin can decrease the molecules that cause delirium in the elderly and central respiratory depression, such as benzodiazepines and antipsychotics. Melatonin may help alleviate infection-induced acute respiratory distress as well as its diverse effects, which include anti-inflammatory, antioxidative, and immune-enhancing properties. Its supplemental dose may be able to prevent SARS-COV-2 infections by reversing aerobic glycolysis via suppression of both HIF-1 and mTOR, allowing pyruvate dehydrogenase complex activity to be suppressed and acetyl-coenzyme A to be produced. When mitochondrion-produced and parenteral melatonin are combined, the cytokine storm is reduced, and COVID-19 infection-induced damage is alleviated. In conclusion, melatonin could have an important role in the management of COVID-19.},
}
%0 Journal Article
%A Mohamed, Rehab Mohamed Ali
%A Amin, Ghada Essam El-Din
%A Rahman, Salwa Mostafa Mohammad Abdel
%A Allam, Mohamed Farouk
%D 2022
%J Current Research in Public Health

%@ 2831-5162
%V 2
%N 1
%P 19-22

%T Melatonin could be used for Treatment of COVID-19?
%M doi:10.31586/gjeid.2022.188
%U /2770-867510.31586/gjeid-2-1-310.31586/gjeid/2/1/3

TY  - JOUR
AU  - Mohamed, Rehab Mohamed Ali
AU  - Amin, Ghada Essam El-Din
AU  - Rahman, Salwa Mostafa Mohammad Abdel
AU  - Allam, Mohamed Farouk
TI  - Melatonin could be used for Treatment of COVID-19?
T2  - Current Research in Public Health
PY  - 2022
VL  - 2
IS  - 1
SN  - 2831-5162
SP  - 19
EP  - 22
UR  - /2770-867510.31586/gjeid-2-1-310.31586/gjeid/2/1/3
AB  - Coronaviruses (CoVs) are a broad family of potentially serious RNA viruses that are now causing an outbreak of respiratory disease known as CoV disease 2019 (COVID-19). Melatonin is a pineal hormone that is predominantly produced and released at night from the amino acid tryptophan. Melatonin and its metabolites are also important in immunomodulation, and they have antioxidative properties due to their capacity to scavenge reactive oxygen species both directly and indirectly. COVID-19 leads to changes of altered consciousness levels in about 15% of hospitalized patients, starting from somnolence to disorientation, delirium, stupor, and coma. Melatonin can decrease the molecules that cause delirium in the elderly and central respiratory depression, such as benzodiazepines and antipsychotics. Melatonin may help alleviate infection-induced acute respiratory distress as well as its diverse effects, which include anti-inflammatory, antioxidative, and immune-enhancing properties. Its supplemental dose may be able to prevent SARS-COV-2 infections by reversing aerobic glycolysis via suppression of both HIF-1 and mTOR, allowing pyruvate dehydrogenase complex activity to be suppressed and acetyl-coenzyme A to be produced. When mitochondrion-produced and parenteral melatonin are combined, the cytokine storm is reduced, and COVID-19 infection-induced damage is alleviated. In conclusion, melatonin could have an important role in the management of COVID-19.
DO  - Melatonin could be used for Treatment of COVID-19?
TI  - 10.31586/gjeid.2022.188
ER  -