@Article{crph414,
AUTHOR = {Sahu, Vishnu Kumar and Singh, Rajesh Kumar and Singh, Pashupati Prasad},
TITLE = {Drug-Receptor Interaction of Peptidic HIV-1 Protease: Polar Effect-II},
JOURNAL = {Current Research in Public Health},
VOLUME = {2},
YEAR = {2022},
NUMBER = {1},
PAGES = {1-11},
URL = {https://www.scipublications.com/journal/index.php/OJMR/article/view/414},
ISSN = {2831-5162},
DOI = {10.31586/ojmr.2022.414},
ABSTRACT = {Klopman described the chemical reaction of metal ions and base ions in term of softness, E‡n and E‡m, respectively. By simple modification of known methods, Singh et al. made it applicable for neutral Lewis acids (transition metal salts) and bases (organic molecules) and also extended its application to biological systems for site selectivity and to explain reaction mechanism (markovnikov and anti-markovnikov rule), ligand-receptor interaction of testosterones, estrogens and tetrahydroimidazobenzodiazepinone. In this study effective atomic softness E‡n(eff) and E‡m(eff), and their change ΔE‡nm have been used for site selectivity and polar interaction between 51 peptidic HIV-1 protease inhibitors and receptor amino acids. ΔE‡nm values derived from drug-receptor interaction show that when one moiety on receptor behaves as nucleophile (O of valine amino acid) at the same time maximum electrophilic site of the drug (C-atom of the maximum E‡n(eff) value) orient itself to come close the respective site and make maximum interaction, while when another moiety on receptor behaves as electrophilic site (C of isoleucine amino acid), at the same time maximum nucleophilic site of the drug (O-atom of the maximum E‡m(eff) value) also orient itself to come close the respective site and make maximum interaction.},
}

%0 Journal Article
%A Sahu, Vishnu Kumar
%A Singh, Rajesh Kumar
%A Singh, Pashupati Prasad
%D 2022
%J Current Research in Public Health

%@ 2831-5162
%V 2
%N 1
%P 1-11

%T Drug-Receptor Interaction of Peptidic HIV-1 Protease: Polar Effect-II
%M doi:10.31586/ojmr.2022.414
%U https://www.scipublications.com/journal/index.php/OJMR/article/view/414

TY  - JOUR
AU  - Sahu, Vishnu Kumar
AU  - Singh, Rajesh Kumar
AU  - Singh, Pashupati Prasad
TI  - Drug-Receptor Interaction of Peptidic HIV-1 Protease: Polar Effect-II
T2  - Current Research in Public Health
PY  - 2022
VL  - 2
IS  - 1
SN  - 2831-5162
SP  - 1
EP  - 11
UR  - https://www.scipublications.com/journal/index.php/OJMR/article/view/414
AB  - Klopman described the chemical reaction of metal ions and base ions in term of softness, E‡n and E‡m, respectively. By simple modification of known methods, Singh et al. made it applicable for neutral Lewis acids (transition metal salts) and bases (organic molecules) and also extended its application to biological systems for site selectivity and to explain reaction mechanism (markovnikov and anti-markovnikov rule), ligand-receptor interaction of testosterones, estrogens and tetrahydroimidazobenzodiazepinone. In this study effective atomic softness E‡n(eff) and E‡m(eff), and their change ΔE‡nm have been used for site selectivity and polar interaction between 51 peptidic HIV-1 protease inhibitors and receptor amino acids. ΔE‡nm values derived from drug-receptor interaction show that when one moiety on receptor behaves as nucleophile (O of valine amino acid) at the same time maximum electrophilic site of the drug (C-atom of the maximum E‡n(eff) value) orient itself to come close the respective site and make maximum interaction, while when another moiety on receptor behaves as electrophilic site (C of isoleucine amino acid), at the same time maximum nucleophilic site of the drug (O-atom of the maximum E‡m(eff) value) also orient itself to come close the respective site and make maximum interaction.
DO  - Drug-Receptor Interaction of Peptidic HIV-1 Protease: Polar Effect-II
TI  - 10.31586/ojmr.2022.414
ER  -