@Article{crph6088,
AUTHOR = {Neto, Lauro Barbosa and Silva, Gabriel Rodrigues and Oliveira, Leandro Alves de and Trindade, Andrei Machado Viegas da and Bucar, Hamilton Leão and Prado, Reuder Pereira and Lima, Renner Kesley Silva and Nora, Fernanda Grazielle da Silva Azevedo},
TITLE = {Periprosthetic Joint Infections in Total Hip Arthroplasty: Diagnostic Advances, Treatment Algorithms, and Technological Innovations — A Comprehensive Review},
JOURNAL = {Current Research in Public Health},
VOLUME = {1},
YEAR = {2025},
NUMBER = {1},
PAGES = {38-50},
URL = {https://www.scipublications.com/journal/index.php/GJO/article/view/6088},
ISSN = {2831-5162},
DOI = {10.31586/gjo.2025.6088},
ABSTRACT = {Objective: This integrative review aims to critically examine the clinical management of periprosthetic joint infections (PJI) in total hip arthroplasty (THA), emphasizing decision-making strategies, diagnostic advancements, and therapeutic innovations. The study focuses on the complexity of infection control, microbial resistance, and individualized treatment planning. Methods: A systematic review of the literature was conducted using PubMed, Scopus, Web of Science, and Google Scholar, targeting studies published between 2015 and 2025. Articles were selected based on their contribution to understanding the clinical, microbiological, and surgical aspects of PJI in THA. Fifty-five studies met the inclusion criteria and were analyzed descriptively. Results: PJI in THA is influenced by multifactorial risk profiles, including obesity, diabetes, and immunosuppression. Staphylococcus aureus, particularly MRSA, remains the most frequently isolated pathogen, followed by Gram-negative organisms and fungal species. Diagnostic innovations such as next-generation sequencing have enhanced pathogen detection, while two-stage revision remains the gold standard for chronic infections. Emerging strategies—such as antimicrobial coatings, tailored antibiotic protocols, and multidisciplinary care models—demonstrate promise in improving clinical outcomes. Conclusion: Managing PJI in THA necessitates a comprehensive and individualized approach, integrating early and accurate diagnosis, pathogen-specific treatment, and advanced preventive measures. The integration of emerging technologies and personalized care pathways is critical to optimizing outcomes and reducing the clinical and economic burden of PJI.},
}

%0 Journal Article
%A Neto, Lauro Barbosa
%A Silva, Gabriel Rodrigues
%A Oliveira, Leandro Alves de
%A Trindade, Andrei Machado Viegas da
%A Bucar, Hamilton Leão
%A Prado, Reuder Pereira
%A Lima, Renner Kesley Silva
%A Nora, Fernanda Grazielle da Silva Azevedo
%D 2025
%J Current Research in Public Health

%@ 2831-5162
%V 1
%N 1
%P 38-50

%T Periprosthetic Joint Infections in Total Hip Arthroplasty: Diagnostic Advances, Treatment Algorithms, and Technological Innovations — A Comprehensive Review
%M doi:10.31586/gjo.2025.6088
%U https://www.scipublications.com/journal/index.php/GJO/article/view/6088

TY  - JOUR
AU  - Neto, Lauro Barbosa
AU  - Silva, Gabriel Rodrigues
AU  - Oliveira, Leandro Alves de
AU  - Trindade, Andrei Machado Viegas da
AU  - Bucar, Hamilton Leão
AU  - Prado, Reuder Pereira
AU  - Lima, Renner Kesley Silva
AU  - Nora, Fernanda Grazielle da Silva Azevedo
TI  - Periprosthetic Joint Infections in Total Hip Arthroplasty: Diagnostic Advances, Treatment Algorithms, and Technological Innovations — A Comprehensive Review
T2  - Current Research in Public Health
PY  - 2025
VL  - 1
IS  - 1
SN  - 2831-5162
SP  - 38
EP  - 50
UR  - https://www.scipublications.com/journal/index.php/GJO/article/view/6088
AB  - Objective: This integrative review aims to critically examine the clinical management of periprosthetic joint infections (PJI) in total hip arthroplasty (THA), emphasizing decision-making strategies, diagnostic advancements, and therapeutic innovations. The study focuses on the complexity of infection control, microbial resistance, and individualized treatment planning. Methods: A systematic review of the literature was conducted using PubMed, Scopus, Web of Science, and Google Scholar, targeting studies published between 2015 and 2025. Articles were selected based on their contribution to understanding the clinical, microbiological, and surgical aspects of PJI in THA. Fifty-five studies met the inclusion criteria and were analyzed descriptively. Results: PJI in THA is influenced by multifactorial risk profiles, including obesity, diabetes, and immunosuppression. Staphylococcus aureus, particularly MRSA, remains the most frequently isolated pathogen, followed by Gram-negative organisms and fungal species. Diagnostic innovations such as next-generation sequencing have enhanced pathogen detection, while two-stage revision remains the gold standard for chronic infections. Emerging strategies—such as antimicrobial coatings, tailored antibiotic protocols, and multidisciplinary care models—demonstrate promise in improving clinical outcomes. Conclusion: Managing PJI in THA necessitates a comprehensive and individualized approach, integrating early and accurate diagnosis, pathogen-specific treatment, and advanced preventive measures. The integration of emerging technologies and personalized care pathways is critical to optimizing outcomes and reducing the clinical and economic burden of PJI.
DO  - Periprosthetic Joint Infections in Total Hip Arthroplasty: Diagnostic Advances, Treatment Algorithms, and Technological Innovations — A Comprehensive Review
TI  - 10.31586/gjo.2025.6088
ER  -