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Case Report Open Access July 12, 2025

Nodal Marginal Zone Lymphoma with IgG and IgM Secretion of Kappa Light Chain: Case Report

Kaoutar Jamal 1,*, Dounia El Moujtahide 1, El-Houcine Sebbar 1 and Mohammed Choukri 1
1
Mohammed First University, Faculty of Medicine and Pharmacy of Oujda, Mohammed VI University Hospital, Biochemistry laboratory, 6000, Oujda, Morocco
Publihed in: Current Research in Public Health (Volume 5, Issue 1, 2025)
Page(s): 19-24
DOI: 10.31586/gjmcr.2025.6127
Received
May 29, 2025
Revised
June 26, 2025
Accepted
July 07, 2025
Published
July 12, 2025
Keywords
Marginal Zone Lymphoma; IgG; IgM; Kappa; Lambda
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2025. Published by Scientific Publications
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Cite This Article

APA Style
Jamal, K. , Jamal, K. Moujtahide, D. E. , Moujtahide, D. E. Sebbar, E. , & Sebbar, E. (2025). Nodal Marginal Zone Lymphoma with IgG and IgM Secretion of Kappa Light Chain: Case Report. Current Research in Public Health, 5(1), 19-24. https://doi.org/10.31586/gjmcr.2025.6127
ACS Style
Jamal, K. ; Jamal, K. Moujtahide, D. E. ; Moujtahide, D. E. Sebbar, E. ; Sebbar, E. Nodal Marginal Zone Lymphoma with IgG and IgM Secretion of Kappa Light Chain: Case Report. Current Research in Public Health 2025 5(1), 19-24. https://doi.org/10.31586/gjmcr.2025.6127
Chicago/Turabian Style
Jamal, Kaoutar, Kaoutar Jamal. Dounia El Moujtahide, Dounia El Moujtahide. El-Houcine Sebbar, and El-Houcine Sebbar. 2025. "Nodal Marginal Zone Lymphoma with IgG and IgM Secretion of Kappa Light Chain: Case Report". Current Research in Public Health 5, no. 1: 19-24. https://doi.org/10.31586/gjmcr.2025.6127
AMA Style
Jamal K, Jamal KMoujtahide DE, Moujtahide DESebbar E, Sebbar E. Nodal Marginal Zone Lymphoma with IgG and IgM Secretion of Kappa Light Chain: Case Report. Current Research in Public Health. 2025; 5(1):19-24. https://doi.org/10.31586/gjmcr.2025.6127 
@Article{crph6127,
AUTHOR = {Jamal, Kaoutar and Moujtahide, Dounia El and Sebbar, El-Houcine and Choukri, Mohammed},
TITLE = {Nodal Marginal Zone Lymphoma with IgG and IgM Secretion of Kappa Light Chain: Case Report},
JOURNAL = {Current Research in Public Health},
VOLUME = {5},
YEAR = {2025},
NUMBER = {1},
PAGES = {19-24},
URL = {https://www.scipublications.com/journal/index.php/GJMCR/article/view/6127},
ISSN = {2831-5162},
DOI = {10.31586/gjmcr.2025.6127},
ABSTRACT = {Nodal marginal zone lymphomas are indolent and rare non-Hodgkin lymphomas, most often diagnosed at an advanced stage. Their clinical presentations are typically insidious, which can lead to delayed diagnosis. The concomitant secretion of IgM and IgG immunoglobulins with kappa light chains constitutes an exceptional feature in this type of lymphoma, as illustrated by our case. We report the case of a 62-year-old man with a history of treated syphilis and inferior vena cava thrombosis managed with rivaroxaban, who presented with a left inguinal mass evolving over three months, accompanied by fever, night sweats, and weight loss. Clinical examination revealed non-inflammatory left inguinal lymphadenopathy without other abnormalities. Laboratory tests showed non-regenerative anemia, leukopenia, and elevated LDH levels. Protein electrophoresis revealed a monoclonal peak in the gamma region, confirmed by serum immunofixation showing two monoclonal bands of IgG kappa and IgM kappa types. Biopsy of the inguinal lymph node revealed histological and immunohistochemical features consistent with a small B-cell marginal zone lymphoma, staged as IV based on the extension workup. A chemotherapy regimen consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was initiated, resulting in a partial response after four cycles. The coexpression of IgM and IgG kappa light chains in nodal marginal zone lymphomas, which are already rare, is an unusual finding. This particularity warrants multicenter studies to better assess its diagnostic, prognostic, and therapeutic implications.},
}
%0 Journal Article
%A Jamal, Kaoutar
%A Moujtahide, Dounia El
%A Sebbar, El-Houcine
%A Choukri, Mohammed
%D 2025
%J Current Research in Public Health

%@ 2831-5162
%V 5
%N 1
%P 19-24

%T Nodal Marginal Zone Lymphoma with IgG and IgM Secretion of Kappa Light Chain: Case Report
%M doi:10.31586/gjmcr.2025.6127
%U https://www.scipublications.com/journal/index.php/GJMCR/article/view/6127

TY  - JOUR
AU  - Jamal, Kaoutar
AU  - Moujtahide, Dounia El
AU  - Sebbar, El-Houcine
AU  - Choukri, Mohammed
TI  - Nodal Marginal Zone Lymphoma with IgG and IgM Secretion of Kappa Light Chain: Case Report
T2  - Current Research in Public Health
PY  - 2025
VL  - 5
IS  - 1
SN  - 2831-5162
SP  - 19
EP  - 24
UR  - https://www.scipublications.com/journal/index.php/GJMCR/article/view/6127
AB  - Nodal marginal zone lymphomas are indolent and rare non-Hodgkin lymphomas, most often diagnosed at an advanced stage. Their clinical presentations are typically insidious, which can lead to delayed diagnosis. The concomitant secretion of IgM and IgG immunoglobulins with kappa light chains constitutes an exceptional feature in this type of lymphoma, as illustrated by our case. We report the case of a 62-year-old man with a history of treated syphilis and inferior vena cava thrombosis managed with rivaroxaban, who presented with a left inguinal mass evolving over three months, accompanied by fever, night sweats, and weight loss. Clinical examination revealed non-inflammatory left inguinal lymphadenopathy without other abnormalities. Laboratory tests showed non-regenerative anemia, leukopenia, and elevated LDH levels. Protein electrophoresis revealed a monoclonal peak in the gamma region, confirmed by serum immunofixation showing two monoclonal bands of IgG kappa and IgM kappa types. Biopsy of the inguinal lymph node revealed histological and immunohistochemical features consistent with a small B-cell marginal zone lymphoma, staged as IV based on the extension workup. A chemotherapy regimen consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was initiated, resulting in a partial response after four cycles. The coexpression of IgM and IgG kappa light chains in nodal marginal zone lymphomas, which are already rare, is an unusual finding. This particularity warrants multicenter studies to better assess its diagnostic, prognostic, and therapeutic implications.
DO  - Nodal Marginal Zone Lymphoma with IgG and IgM Secretion of Kappa Light Chain: Case Report
TI  - 10.31586/gjmcr.2025.6127
ER  -