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Current Research in Public Health
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  5. Volume 5, Number 1, 2025
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  7. Table 3

The association between serum α1-AGP and chronic kidney disease among US female ages 20 to 49 years: Results from the 2015-2018 National Health and Nutrition Survey

Table 3.

Association between serum α1-AGP and CKD in the multiple logistic regression model.
Variables n.event% Crude OR (95% CI) Model 1 OR (95% CI) Model 2 OR (95% CI) Model 3 OR (95% CI)
CKD 188 (8.8) 0.50 (0.26~0.96) * 0.48 (0.25~0.94) * 0.39 (0.02~0.78) * 0.37 (0.16~0.84) *
α1-AGP Q1 54 (10.1) 1(Ref) 1(Ref) 1(Ref) 1(Ref)
α1-AGP Q2 53 (10.0) 0.99 (0.66~1.48) 0.97 (0.65~1.45) 0.97 (0.64~1.46) 1.08(0.7~1.67)
α1-AGP Q3 45 (8.4) 0.81 (0.54~1.23) 0.79 (0.52~1.20) 0.73 (0.47~1.12) 0.85(0.54~1.34)
α1-AGP Q4 36 (6.7) 0.64 (0.41~0.99) * 0.64 (0.41~0.99) * 0.58 (0.37~0.92) * 0.58(0.34~0.99) *
Trend test   0.031* 0.029* 0.009* 0.041*

Model 1: Age, Educational level; Model 2: Model 1+ BMI, SBP, DBP, Hypertension, Diabetes, physical activity; Model 3: Model 2+ Cholesterol, uric acid, hs-CRP, Ferritin, Vitamin D, HbA1c, Folate, HGB; *p < 0.05

OR, Odds Ratio; CI, Confidence Interval; CKD, Chronic Kidney Disease; α1-AGP, Serum Alpha-1-Acid Glycoprotein; Ref: Reference group (used to denote the group used as the baseline for comparison); Q1, Q2, Q3, Q4: Quartiles of Serum Alpha-1-Acid Glycoprotein (Q1 = lowest quartile, Q4 = highest quartile).