Science Publications

Sign Up
Sign In
Submit
Current Research in Public Health
Cite This Article Share Download PDF XML
  1. Home
  2. Journals
  3. Current Research in Public Health
  4. Archive
  5. Volume 3, Issue 1, 2025
  6. Article
Brief Report Open Access September 28, 2025

Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis

Avam Arora 1,*
1
Redmond High School, USA
Publihed in: Current Research in Public Health (Volume 3, Issue 1, 2025)
Page(s): 47-51
DOI: 10.31586/ojn.2025.6169
Received
July 29, 2025
Revised
September 02, 2025
Accepted
September 26, 2025
Published
September 28, 2025
Keywords
Autism Spectrum Disorder; Gut–Brain Axis; Microbiome; Metabolites; Bibliometric Analysis; Short-Chain Fatty Acids; Serotonin; Network Modeling
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2025. Published by Scientific Publications
Article metrics
Views
85
Downloads
0

Cite This Article

APA Style
Arora, A. (2025). Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis. Current Research in Public Health, 3(1), 47-51. https://doi.org/10.31586/ojn.2025.6169
ACS Style
Arora, A. Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis. Current Research in Public Health 2025 3(1), 47-51. https://doi.org/10.31586/ojn.2025.6169
Chicago/Turabian Style
Arora, Avam. 2025. "Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis". Current Research in Public Health 3, no. 1: 47-51. https://doi.org/10.31586/ojn.2025.6169
AMA Style
Arora A. Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis. Current Research in Public Health. 2025; 3(1):47-51. https://doi.org/10.31586/ojn.2025.6169 
@Article{crph6169,
AUTHOR = {Arora, Avam},
TITLE = {Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis},
JOURNAL = {Current Research in Public Health},
VOLUME = {3},
YEAR = {2025},
NUMBER = {1},
PAGES = {47-51},
URL = {https://www.scipublications.com/journal/index.php/ojn/article/view/6169},
ISSN = {2831-5162},
DOI = {10.31586/ojn.2025.6169},
ABSTRACT = {The gut-brain axis (GBA) has emerged as a central focus in the study of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). Research suggests that microbial composition and its metabolic byproducts influence neural development, synaptic plasticity, and behavior [1,2,3]. A structured bibliometric analysis of Scopus and Web of Science records was performed using Bibliometrix and VOSviewer to trace trends and thematic evolution of GBA–ASD literature [7,8]. In parallel, a data-driven pathway modeling approach maps microbial metabolites (e.g., short-chain fatty acids, tryptophan catabolites) to host signaling pathways including vagal stimulation, immune cytokine modulation, and blood–brain barrier (BBB) permeability [4,5]. Simulations implemented in Python’s NetworkX illustrate how perturbations in metabolite flux may influence CNS outcomes. The findings reveal growing emphasis on butyrate, serotonin, microglial priming, and maternal immune activation in ASD-related GBA studies, and highlight the need for rigorous empirical validation of computational predictions [9,10,11].},
}
%0 Journal Article
%A Arora, Avam
%D 2025
%J Current Research in Public Health

%@ 2831-5162
%V 3
%N 1
%P 47-51

%T Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis
%M doi:10.31586/ojn.2025.6169
%U https://www.scipublications.com/journal/index.php/ojn/article/view/6169

TY  - JOUR
AU  - Arora, Avam
TI  - Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis
T2  - Current Research in Public Health
PY  - 2025
VL  - 3
IS  - 1
SN  - 2831-5162
SP  - 47
EP  - 51
UR  - https://www.scipublications.com/journal/index.php/ojn/article/view/6169
AB  - The gut-brain axis (GBA) has emerged as a central focus in the study of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). Research suggests that microbial composition and its metabolic byproducts influence neural development, synaptic plasticity, and behavior [1,2,3]. A structured bibliometric analysis of Scopus and Web of Science records was performed using Bibliometrix and VOSviewer to trace trends and thematic evolution of GBA–ASD literature [7,8]. In parallel, a data-driven pathway modeling approach maps microbial metabolites (e.g., short-chain fatty acids, tryptophan catabolites) to host signaling pathways including vagal stimulation, immune cytokine modulation, and blood–brain barrier (BBB) permeability [4,5]. Simulations implemented in Python’s NetworkX illustrate how perturbations in metabolite flux may influence CNS outcomes. The findings reveal growing emphasis on butyrate, serotonin, microglial priming, and maternal immune activation in ASD-related GBA studies, and highlight the need for rigorous empirical validation of computational predictions [9,10,11].
DO  - Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis
TI  - 10.31586/ojn.2025.6169
ER  -