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Case Report Open Access December 15, 2025

Wernicke’s Encephalopathy: A Series of 7 Cases and Literature Review

Siham Bahbouh 1, 2,* and Meriem Ouali 2, 3
1
University of Health Sciences Doctor Youcef El Khatib, Faculty of Medicine of Algiers, Algeria
2
Neurology Service, Neurosurgical Hospital Ali Ait Idir, Algiers, Algeria
3
Neuropsychologist, Neurosurgical Hospital Ali Ait Idir, Algiers, Algeria
Publihed in: Current Research in Public Health (Volume 4, Issue 1, 2025)
Page(s): 28-34
DOI: 10.31586/ujog.2025.6231
Received
November 02, 2025
Revised
December 07, 2025
Accepted
December 12, 2025
Published
December 15, 2025
Keywords
: Pregnancy; Hyperemesis Gravidarum; Alcoholism; Thiamine Deficiency; Wernicke’s Encephalopathy
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2025. Published by Scientific Publications
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Cite This Article

APA Style
Bahbouh, S. , & Ouali, M. (2025). Wernicke’s Encephalopathy: A Series of 7 Cases and Literature Review. Current Research in Public Health, 4(1), 28-34. https://doi.org/10.31586/ujog.2025.6231
ACS Style
Bahbouh, S. ; Ouali, M. Wernicke’s Encephalopathy: A Series of 7 Cases and Literature Review. Current Research in Public Health 2025 4(1), 28-34. https://doi.org/10.31586/ujog.2025.6231
Chicago/Turabian Style
Bahbouh, Siham, and Meriem Ouali. 2025. "Wernicke’s Encephalopathy: A Series of 7 Cases and Literature Review". Current Research in Public Health 4, no. 1: 28-34. https://doi.org/10.31586/ujog.2025.6231
AMA Style
Bahbouh S, Ouali M. Wernicke’s Encephalopathy: A Series of 7 Cases and Literature Review. Current Research in Public Health. 2025; 4(1):28-34. https://doi.org/10.31586/ujog.2025.6231 
@Article{crph6231,
AUTHOR = {Bahbouh, Siham and Ouali, Meriem},
TITLE = {Wernicke’s Encephalopathy: A Series of 7 Cases and Literature Review},
JOURNAL = {Current Research in Public Health},
VOLUME = {4},
YEAR = {2025},
NUMBER = {1},
PAGES = {28-34},
URL = {https://www.scipublications.com/journal/index.php/UJOG/article/view/6231},
ISSN = {2831-5162},
DOI = {10.31586/ujog.2025.6231},
ABSTRACT = {Wernicke’s encephalopathy (WE) is a neurological emergency related to a severe thiamine (vitamin B1) deficiency, an essential cofactor in cerebral energy metabolism. Although historically associated with chronic alcoholism, this condition can occur in any context of malnutrition, prolonged vomiting, or hypercatabolism. We conducted a retrospective descriptive study on seven patients admitted to our neurology department between 2015 and 2020, in order to de-scribe the clinical, radiological, and outcome characteristics of this pathology. The diagnosis was made in the presence of suggestive signs (at least two among confusion, ataxia, oculomotor disorders), a risk context of deficiency or malnutrition, typical MRI abnormalities and/or rapid improvement after thiamine ad-ministration. Our series included two male patients with chronic alcohol consumption, and five pregnant women with severe hyperemesis gravidarum, with an average age of 32.4 years. Mental confusion was the most frequent sign, followed by gait disturbances and oculomotor abnormalities. The most characteristic MRI lesions involved the thalamus, the periaqueductal region, and the mammillary bodies. All patients received high-dose intravenous thiamine supplementation (500 mg every eight hours for three days), followed by oral maintenance therapy. The outcome was favorable in five cases, while two patients had persistent memory disorders. These observations confirm that WE is not limited to alcoholic forms and must be considered in any situation with nutritional risk. Early diagnosis and rapid administration of intravenous thiamine remain essential to prevent irreversible neurological sequelae and improve functional prognosis.},
}
%0 Journal Article
%A Bahbouh, Siham
%A Ouali, Meriem
%D 2025
%J Current Research in Public Health

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%V 4
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%T Wernicke’s Encephalopathy: A Series of 7 Cases and Literature Review
%M doi:10.31586/ujog.2025.6231
%U https://www.scipublications.com/journal/index.php/UJOG/article/view/6231

TY  - JOUR
AU  - Bahbouh, Siham
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AB  - Wernicke’s encephalopathy (WE) is a neurological emergency related to a severe thiamine (vitamin B1) deficiency, an essential cofactor in cerebral energy metabolism. Although historically associated with chronic alcoholism, this condition can occur in any context of malnutrition, prolonged vomiting, or hypercatabolism. We conducted a retrospective descriptive study on seven patients admitted to our neurology department between 2015 and 2020, in order to de-scribe the clinical, radiological, and outcome characteristics of this pathology. The diagnosis was made in the presence of suggestive signs (at least two among confusion, ataxia, oculomotor disorders), a risk context of deficiency or malnutrition, typical MRI abnormalities and/or rapid improvement after thiamine ad-ministration. Our series included two male patients with chronic alcohol consumption, and five pregnant women with severe hyperemesis gravidarum, with an average age of 32.4 years. Mental confusion was the most frequent sign, followed by gait disturbances and oculomotor abnormalities. The most characteristic MRI lesions involved the thalamus, the periaqueductal region, and the mammillary bodies. All patients received high-dose intravenous thiamine supplementation (500 mg every eight hours for three days), followed by oral maintenance therapy. The outcome was favorable in five cases, while two patients had persistent memory disorders. These observations confirm that WE is not limited to alcoholic forms and must be considered in any situation with nutritional risk. Early diagnosis and rapid administration of intravenous thiamine remain essential to prevent irreversible neurological sequelae and improve functional prognosis.
DO  - Wernicke’s Encephalopathy: A Series of 7 Cases and Literature Review
TI  - 10.31586/ujog.2025.6231
ER  -