Review Article Open Access December 30, 2025

Elimination of HIV Transmission Risks through Viral Suppression: Undetectable=Untransmittable and its Impact among People Living with HIV

1
Department of Public-Private Partnership, JSI Research and Training Institute, Bayelsa, Nigeria
2
Department of Program Management, Real Talks Concept, Abuja, Nigeria
3
Department of Inspection, Monitoring and Quality Assurance, Pharmacy Council of Nigeria, Bayelsa, Nigeria
4
Faculty of Science, Niger Delta University, Bayelsa, Nigeria
5
Department of Health Services Management and Policy, College of Public Health, East Tennesse State University, Tennesse, United States
6
Department of Program Associates, JSI Research and Training Institute, Bayelsa, Nigeria
7
Department of Obstetrics and Gynaecology, Dames’ Infirmary Hospital and Maternity, Bayelsa, Nigeria
8
Department of Clinical Services, Prisdion Pharmacy Limited, Delta, Nigeria
9
Department of Programs, Knowledge Network for Disease Control and Vigilance, Lagos, Nigeria
Page(s): 54-69
Received
November 16, 2025
Revised
December 19, 2025
Accepted
December 28, 2025
Published
December 30, 2025
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2025. Published by Scientific Publications
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APA Style
Foster-Pagaebi, E. , Foster-Pagaebi, E. Douglas, T. , Douglas, T. Enebeli, S. N. , Enebeli, S. N. Ezeke, P. G. , Ezeke, P. G. Ogundeko-Olugbami, O. , Ogundeko-Olugbami, O. Kikile, I. , Kikile, I. James, B. N. , James, B. N. Odion, P. O. , & Odion, P. O. (2025). Elimination of HIV Transmission Risks through Viral Suppression: Undetectable=Untransmittable and its Impact among People Living with HIV. Current Research in Public Health, 5(1), 54-69. https://doi.org/10.31586/gjeid.2025.6245
ACS Style
Foster-Pagaebi, E. ; Foster-Pagaebi, E. Douglas, T. ; Douglas, T. Enebeli, S. N. ; Enebeli, S. N. Ezeke, P. G. ; Ezeke, P. G. Ogundeko-Olugbami, O. ; Ogundeko-Olugbami, O. Kikile, I. ; Kikile, I. James, B. N. ; James, B. N. Odion, P. O. ; Odion, P. O. Elimination of HIV Transmission Risks through Viral Suppression: Undetectable=Untransmittable and its Impact among People Living with HIV. Current Research in Public Health 2025 5(1), 54-69. https://doi.org/10.31586/gjeid.2025.6245
Chicago/Turabian Style
Foster-Pagaebi, Evelyn, Evelyn Foster-Pagaebi. Tamunomiebi Douglas, Tamunomiebi Douglas. Solomon Nduka Enebeli, Solomon Nduka Enebeli. Pagaebi Garcia Ezeke, Pagaebi Garcia Ezeke. Oluwafunmilayo Ogundeko-Olugbami, Oluwafunmilayo Ogundeko-Olugbami. Izibeya Kikile, Izibeya Kikile. Buniminaki Nimi James, Buniminaki Nimi James. Prisca Omonigho Odion, and Prisca Omonigho Odion. 2025. "Elimination of HIV Transmission Risks through Viral Suppression: Undetectable=Untransmittable and its Impact among People Living with HIV". Current Research in Public Health 5, no. 1: 54-69. https://doi.org/10.31586/gjeid.2025.6245
AMA Style
Foster-Pagaebi E, Foster-Pagaebi EDouglas T, Douglas TEnebeli SN, Enebeli SNEzeke PG, Ezeke PGOgundeko-Olugbami O, Ogundeko-Olugbami OKikile I, Kikile IJames BN, James BNOdion PO, Odion PO. Elimination of HIV Transmission Risks through Viral Suppression: Undetectable=Untransmittable and its Impact among People Living with HIV. Current Research in Public Health. 2025; 5(1):54-69. https://doi.org/10.31586/gjeid.2025.6245
@Article{crph6245,
AUTHOR = {Foster-Pagaebi, Evelyn and Douglas, Tamunomiebi and Enebeli, Solomon Nduka and Ezeke, Pagaebi Garcia and Ogundeko-Olugbami, Oluwafunmilayo and Kikile, Izibeya and James, Buniminaki Nimi and Odion, Prisca Omonigho and Oboku-Aganaba, Amavie},
TITLE = {Elimination of HIV Transmission Risks through Viral Suppression: Undetectable=Untransmittable and its Impact among People Living with HIV},
JOURNAL = {Current Research in Public Health},
VOLUME = {5},
YEAR = {2025},
NUMBER = {1},
PAGES = {54-69},
URL = {https://www.scipublications.com/journal/index.php/GJEID/article/view/6245},
ISSN = {2831-5162},
DOI = {10.31586/gjeid.2025.6245},
ABSTRACT = {The principle of Undetectable = Untransmittable (U=U) posits that people living with the human immunodeficiency virus (HIV) who are able to achieve and maintain a viral load of <200 copies/mL by regularly taking antiretroviral drugs (ARVs) are considered virally suppressed and cannot transmit the HIV virus to other individuals through sex. This groundbreaking message has emerged as a key HIV prevention strategy for eliminating transmission risks and enhancing the quality of life of people living with HIV. This narrative review explores the clinical foundation of U=U, the level of awareness and acceptance of the message globally, and the psychosocial impact on people living with HIV. It has been discovered that this message minimizes stigma, improves mental health, promote treatment adherence and good disclosure behaviors among people living with HIV. Evidence has shown that despite the U=U revolution for HIV prevention, there are significant differences in awareness and acceptance of the message among different population groups. The challenges noted were poor communication by healthcare providers, limitations in the health system, and stigma issues. Nevertheless, the inclusion of U=U in mainstream HIV services has proven to increase awareness and enhance its adoption. The urgent need in the present review is to advocate for strategies to increase the equitable distribution of U=U to harness its full potential in public health.},
}
%0 Journal Article
%A Foster-Pagaebi, Evelyn
%A Douglas, Tamunomiebi
%A Enebeli, Solomon Nduka
%A Ezeke, Pagaebi Garcia
%A Ogundeko-Olugbami, Oluwafunmilayo
%A Kikile, Izibeya
%A James, Buniminaki Nimi
%A Odion, Prisca Omonigho
%A Oboku-Aganaba, Amavie
%D 2025
%J Current Research in Public Health

%@ 2831-5162
%V 5
%N 1
%P 54-69

%T Elimination of HIV Transmission Risks through Viral Suppression: Undetectable=Untransmittable and its Impact among People Living with HIV
%M doi:10.31586/gjeid.2025.6245
%U https://www.scipublications.com/journal/index.php/GJEID/article/view/6245
TY  - JOUR
AU  - Foster-Pagaebi, Evelyn
AU  - Douglas, Tamunomiebi
AU  - Enebeli, Solomon Nduka
AU  - Ezeke, Pagaebi Garcia
AU  - Ogundeko-Olugbami, Oluwafunmilayo
AU  - Kikile, Izibeya
AU  - James, Buniminaki Nimi
AU  - Odion, Prisca Omonigho
AU  - Oboku-Aganaba, Amavie
TI  - Elimination of HIV Transmission Risks through Viral Suppression: Undetectable=Untransmittable and its Impact among People Living with HIV
T2  - Current Research in Public Health
PY  - 2025
VL  - 5
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SN  - 2831-5162
SP  - 54
EP  - 69
UR  - https://www.scipublications.com/journal/index.php/GJEID/article/view/6245
AB  - The principle of Undetectable = Untransmittable (U=U) posits that people living with the human immunodeficiency virus (HIV) who are able to achieve and maintain a viral load of <200 copies/mL by regularly taking antiretroviral drugs (ARVs) are considered virally suppressed and cannot transmit the HIV virus to other individuals through sex. This groundbreaking message has emerged as a key HIV prevention strategy for eliminating transmission risks and enhancing the quality of life of people living with HIV. This narrative review explores the clinical foundation of U=U, the level of awareness and acceptance of the message globally, and the psychosocial impact on people living with HIV. It has been discovered that this message minimizes stigma, improves mental health, promote treatment adherence and good disclosure behaviors among people living with HIV. Evidence has shown that despite the U=U revolution for HIV prevention, there are significant differences in awareness and acceptance of the message among different population groups. The challenges noted were poor communication by healthcare providers, limitations in the health system, and stigma issues. Nevertheless, the inclusion of U=U in mainstream HIV services has proven to increase awareness and enhance its adoption. The urgent need in the present review is to advocate for strategies to increase the equitable distribution of U=U to harness its full potential in public health.
DO  - Elimination of HIV Transmission Risks through Viral Suppression: Undetectable=Untransmittable and its Impact among People Living with HIV
TI  - 10.31586/gjeid.2025.6245
ER  -