Background: Chronic kidney disease (CKD) affects over 35.5 million US adults. Serum α1-acid glycoprotein (α1-AGP), an acute-phase protein, exhibits anti-inflammatory properties in animal models, but its association with CKD in younger women remains underexplored. This study investigated the relationship between serum α1-AGP and CKD risk in US women aged 20–49 years. Methods: This nationally representative cross-sectional study used data on female adults in the US aged 20–49 years from the National Health and Nutrition Examination Survey 2015–2018 cycles. 2,137 individuals were included in the study after excluding individuals without serum α1-AGP, urine albumin, and creatinine data. Multivariate logistic regression models evaluated the association between serum α1-AGP and CKD. Moreover, we performed stratified and interaction analyses to see if the relationship was stable in different subgroups. Results: Among 2,137 participants (mean age 34.6 years, mean eGFR 111.7 mL/min/1.73 m²), CKD prevalence was 8.8% (n=188). Higher serum α1-AGP levels were associated with lower CKD risk in the fully adjusted model (OR 0.37, 95% CI 0.16–0.84, P = 0.017), with a dose-response trend across quartiles (P = 0.041). The association was stronger in women aged 40–49 years (OR 0.20, 95% CI 0.05–0.76) and Mexican Americans (OR 0.07, 95% CI 0.01–0.56), though interaction terms were not significant (P > 0.05). Conclusions: Higher serum α1-AGP levels are associated with lower CKD prevalence in young women, suggesting a protective role. Longitudinal studies are needed to confirm causality and explore α1-AGP as a biomarker for CKD risk stratification.Full article

Avian influenza is a very lethal disease caused by influenza viruses that normally circulate among birds, and contains well-known subtypes are A(H5N1) and A(H7N9). Human infection is rare and occurs through close contact with infected poultry, therefore, confirming a history of such contact is important. The same treatment as for seasonal influenza is recommended, such as the neuraminidase inhibitors, cap endonuclease inhibitors, and RNA polymerase inhibitor. The avian influenza patients are regulated by the Infectious Diseases Control Law in Japan, we should manage the avian influenza appropriately.Full article

Objective: To investigate the status of the acoustic environment of a typical Chinese pediatric emergency care department in a time series and identify the relationship between noise levels and factors such as crowd density and movement. Methods: A descriptive study was designed based on a multi-loci time-series method. We measured three loci under three variable settings: the decibel value, observation volume, and emergency care volume. Results: The noise levels of the three loci were significantly higher than the internationally recommended levels, exceeding rate reached more than 86.3%. The 24-hour mean map of the three loci showed similar fluctuation patterns, all of which had two peaks at approximately 10:00 AM and 16:00 PM. Conclusions: The daytime and nighttime noise levels were well-fitted by cubic functions with different coefficients. It is suggested that crowd density and movement may play important roles in noise mean fluctuations, which can be optimized to ensure a satisfactory environment in a pediatric emergency care department.Full article