@Article{jml559,
AUTHOR = {Lindberg, Lars},
TITLE = {Antibiotic treatment for infection with Shiga toxin producing Escherichia coli infection inducing a hemolytic uremic syndrome},
JOURNAL = {Journal of Mathematics Letters},
VOLUME = {1},
YEAR = {2023},
NUMBER = {1},
PAGES = {11-15},
URL = {https://www.scipublications.com/journal/index.php/UJP/article/view/559},
ISSN = {ISSN Pending},
DOI = {10.31586/ujp.2023.559},
ABSTRACT = {Background: Shiga toxin producing Escherichia coli (STEC) inducing hemolytic uremic syndrome (HUS) with multiple organ involvement is associated with significant morbidity and mortality. The treatment has mostly been focused on kidney, respiratory and cardiovascular supports and not against the bacteria that cause STEC-HUS. The use of bactericidal therapy has been shown to be antibiotic dependent and certain antibiotics inhibit the production and release of Shiga toxin, eradicate STEC without harmful effects, and improve outcome. Methods: A previously healthy 18-months-old girl with STEC causing severe colitis, kidney failure and multi-organ dysfunction was treated with antibiotics that were known to inhibit the release of Shiga toxin as a supplement to supportive care. Results: The antibiotic regime stopped the pathophysiological process with prompt clinical improvement in association with the disappearance of the Shiga toxins. Conclusions: The present case report fortifies and recommends appropriate antibiotic treatment during STEC-HUS, suggesting clinicians to consider the use of these in severe STEC-HUS as early as possible.},
}

%0 Journal Article
%A Lindberg, Lars
%D 2023
%J Journal of Mathematics Letters

%@ ISSN Pending
%V 1
%N 1
%P 11-15

%T Antibiotic treatment for infection with Shiga toxin producing Escherichia coli infection inducing a hemolytic uremic syndrome
%M doi:10.31586/ujp.2023.559
%U https://www.scipublications.com/journal/index.php/UJP/article/view/559

TY  - JOUR
AU  - Lindberg, Lars
TI  - Antibiotic treatment for infection with Shiga toxin producing Escherichia coli infection inducing a hemolytic uremic syndrome
T2  - Journal of Mathematics Letters
PY  - 2023
VL  - 1
IS  - 1
SN  - ISSN Pending
SP  - 11
EP  - 15
UR  - https://www.scipublications.com/journal/index.php/UJP/article/view/559
AB  - Background: Shiga toxin producing Escherichia coli (STEC) inducing hemolytic uremic syndrome (HUS) with multiple organ involvement is associated with significant morbidity and mortality. The treatment has mostly been focused on kidney, respiratory and cardiovascular supports and not against the bacteria that cause STEC-HUS. The use of bactericidal therapy has been shown to be antibiotic dependent and certain antibiotics inhibit the production and release of Shiga toxin, eradicate STEC without harmful effects, and improve outcome. Methods: A previously healthy 18-months-old girl with STEC causing severe colitis, kidney failure and multi-organ dysfunction was treated with antibiotics that were known to inhibit the release of Shiga toxin as a supplement to supportive care. Results: The antibiotic regime stopped the pathophysiological process with prompt clinical improvement in association with the disappearance of the Shiga toxins. Conclusions: The present case report fortifies and recommends appropriate antibiotic treatment during STEC-HUS, suggesting clinicians to consider the use of these in severe STEC-HUS as early as possible.
DO  - Antibiotic treatment for infection with Shiga toxin producing Escherichia coli infection inducing a hemolytic uremic syndrome
TI  - 10.31586/ujp.2023.559
ER  -