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Systematic Review Open Access November 05, 2022

Tight Junctions and Prostate Cancer

Ylermi Soini 1,*
1
Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, PO Box 1627, Kuopio FI-70211, Finland
Publihed in: Universal Journal of Gastroenterology and Hepatology (Volume 1, Issue 1, 2022)
Page(s): 39-53
DOI: 10.31586/wjcor.2022.498
Received
September 26, 2022
Revised
October 26, 2022
Accepted
November 03, 2022
Published
November 05, 2022
Keywords
Prostate; Carcinoma; Claudin; Tight Junction
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2022. Published by Scientific Publications
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Cite This Article

APA Style
Soini, Y. (2022). Tight Junctions and Prostate Cancer. Universal Journal of Gastroenterology and Hepatology, 1(1), 39-53. https://doi.org/10.31586/wjcor.2022.498
ACS Style
Soini, Y. Tight Junctions and Prostate Cancer. Universal Journal of Gastroenterology and Hepatology 2022 1(1), 39-53. https://doi.org/10.31586/wjcor.2022.498
Chicago/Turabian Style
Soini, Ylermi. 2022. "Tight Junctions and Prostate Cancer". Universal Journal of Gastroenterology and Hepatology 1, no. 1: 39-53. https://doi.org/10.31586/wjcor.2022.498
AMA Style
Soini Y. Tight Junctions and Prostate Cancer. Universal Journal of Gastroenterology and Hepatology. 2022; 1(1):39-53. https://doi.org/10.31586/wjcor.2022.498 
@Article{ujgh498,
AUTHOR = {Soini, Ylermi},
TITLE = {Tight Junctions and Prostate Cancer},
JOURNAL = {Universal Journal of Gastroenterology and Hepatology},
VOLUME = {1},
YEAR = {2022},
NUMBER = {1},
PAGES = {39-53},
URL = {https://www.scipublications.com/journal/index.php/WJCOR/article/view/498},
ISSN = {ISSN Pending},
DOI = {10.31586/wjcor.2022.498},
ABSTRACT = {In this review proteins associated with tight junctions (TJs) is described with an emphasis on prostate cancer. Overall tight junctional proteins do not seem to play a decisive role in prostate carcinoma pathogenesis. Of TJ proteins, expression of some claudins show an association with clinical behaviour of the tumors. Claudin 1 expression appears to be related to a better prognosis partly due to its involvement in EMT abrogation. Claudin 3 and 4 are highly expressed in prostate cancer and their expression is associated with aggressive behaviour. Inhibition of claudin 8 promotes prostate carcinoma invasion and spread but studies are few. CPE has been known to bind to especially claudins 3 and 4 and cause cell lysis. Several experiments with modified CPE have been made in prostate cancer cell lines. Regardless of this effective CPE based human treatment for prostate cancer have not yet been developed.},
}
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%A Soini, Ylermi
%D 2022
%J Universal Journal of Gastroenterology and Hepatology

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%T Tight Junctions and Prostate Cancer
%M doi:10.31586/wjcor.2022.498
%U https://www.scipublications.com/journal/index.php/WJCOR/article/view/498

TY  - JOUR
AU  - Soini, Ylermi
TI  - Tight Junctions and Prostate Cancer
T2  - Universal Journal of Gastroenterology and Hepatology
PY  - 2022
VL  - 1
IS  - 1
SN  - ISSN Pending
SP  - 39
EP  - 53
UR  - https://www.scipublications.com/journal/index.php/WJCOR/article/view/498
AB  - In this review proteins associated with tight junctions (TJs) is described with an emphasis on prostate cancer. Overall tight junctional proteins do not seem to play a decisive role in prostate carcinoma pathogenesis. Of TJ proteins, expression of some claudins show an association with clinical behaviour of the tumors. Claudin 1 expression appears to be related to a better prognosis partly due to its involvement in EMT abrogation. Claudin 3 and 4 are highly expressed in prostate cancer and their expression is associated with aggressive behaviour. Inhibition of claudin 8 promotes prostate carcinoma invasion and spread but studies are few. CPE has been known to bind to especially claudins 3 and 4 and cause cell lysis. Several experiments with modified CPE have been made in prostate cancer cell lines. Regardless of this effective CPE based human treatment for prostate cancer have not yet been developed.
DO  - Tight Junctions and Prostate Cancer
TI  - 10.31586/wjcor.2022.498
ER  -