Antibiotic treatment for infection with Shiga toxin producing Escherichia coli infection inducing a hemolytic uremic syndrome

Table 1.

Course of events and laboratory variables.

Parameter

D1

D2

D3

D4

D5

D6

D7

D8

D9

D10

D11

D12

D13

D14

D15

D16

D17

D18

Shiga toxins

+/+

 

 

 

+/+

 

 

+/+

 

 

 

-/-

 

 

-/-

 

 

-/-

Antibiotics

 

 

 

 

 

 

 

M/A

M/A

M/A

M/A

M/A

M/A

M/A

M/A

M/A

M/A

M/A

PICU/W

PICU

PICU

PICU

W

W

W

W

PICU

PICU

PICU

PICU

PICU

PICU

PICU

W

W

W

W

P-CRP

38

45

78

72

70

50

65

52

47

79

40

16

9.5

6.9

9.2

3

 

 

B-WBC

29.6

24.1

22.5

23.5

22.6

20.1

 

37

26.1

29.1

32

24.8

15.8

9.1

 

 

 

 

B-Platelescount

76

83

105

101

93

49

20

15

56

107

237

347

470

373

 

 

 

 

B-Hemoglobin

115

91

121

84

81

80

113

74

102

104

95

95

99

88

92

96

92

89

B-Hematocrit

35

28

37

26

25

25

35

23

32

32

30

30

31

27

29

30

29

28

P-Na

124

126

134

139

139

137

135

137

137

138

134

134

136

135

136

136

138

138

S-LDH

52

 

50

38

 

 

 

 

18

 

11

10

 

 

6,5

 

 

 

P-K

3.7

3.5

4.1

4.4

4.1

4.3

5.4

4.1

3.7

4.3

5.2

4.4

5.0

4.9

4.3

4.7

4.2

4.1

Platelets

 

 

 

 

 

 

 

X

 

 

 

 

 

 

 

 

 

 

P-Creatinine

334

374

397

425

490

469

502

499

170

89

74

160

238

170

249

181

 

 

P-Urea

39.8

41.1

37.6

37.1

39.8

38.7

43.8

47.9

18.3

9

6.8

13.9

21.8

13.2

20.6

12.3

 

 

Diuresis

0

0

0

7

2

5

0

0

12

0

0

0

0

0

0

74

195

291

SAG

 

X

 

 

 

X

 

X

 

 

 

 

 

 

X

 

 

 

Ventilator

 

 

 

 

 

 

 

X

X

X

X

 

 

 

 

 

 

 

D – Day: starting D1 at admittance to the hospital, three days after onset of diarrhea; PICU – Pediatric intensive care unit; W – treatment at the hospital ward, P-CRP – C-reactive protein (mg/L; ref <3 mg/L); B-WBC – white blood count (x109/L); B-Hemoglobin (g/L; ref 100-150 g/L) ; B-Hematocrit (%; 37-41 %); P-Na (Sodium) (mmol/L; ref 137-145 mmol/L); P-K (potassium)( mmol/L ; ref 3.7-4.6 mmol/L; S-LDH- lactate dehydrogenase (µkat/L; ref 2.2 – 5.3 µkat/L) ; P-Creatinine (µmol/L; ref 17-42 µmol/L) ; P-Urea (mmol/l; ref 3.1 – 7.8 mmol/L), SAG - packed red cells diluted with saline-adenine-glucose-mannitol solution, (P – plasma, B - blood, S - serum).

D – Day: starting D1 at admittance to the hospital, three days after onset of diarrhea; PICU – Pediatric intensive care unit; W – treatment at the hospital ward, P-CRP – C-reactive protein (mg/L; ref <3 mg/L); B-WBC – white blood count (x109/L); B-Hemoglobin (g/L; ref 100-150 g/L) ; B-Hematocrit (%; 37-41 %); P-Na (Sodium) (mmol/L; ref 137-145 mmol/L); P-K (potassium)( mmol/L ; ref 3.7-4.6 mmol/L; S-LDH- lactate dehydrogenase (µkat/L; ref 2.2 – 5.3 µkat/L) ; P-Creatinine (µmol/L; ref 17-42 µmol/L) ; P-Urea (mmol/l; ref 3.1 – 7.8 mmol/L), SAG - packed red cells diluted with saline-adenine-glucose-mannitol solution, (P – plasma, B - blood, S - serum).