Characteristic

HR(95%CI)

p-value

a. Univariate cox regression

Age

1.03(1.01-1.05)

0.004^*

Gender

1.50(0.98-2.30)

0.062

Grade

1.25(0.85-1.84)

0.252

Clinical stage

1.51(1.20-1.91)

0.001^*

T stage

1.28(1.00-1.63)

0.050

M stage

2.07(1.07-3.98)

0.030^*

N stage

1.54(0.97-2.45)

0.070

GUCY1A2

1.44(1.03-2.02)

0.034^*

b. Multivariate analysis

Age

1.05(1.02-1.07)

0.000^*

Gender

1.57(1.01-2.44)

0.045^*

Grade

1.33(0.89-1.99)

0.167

Clinical stage

1.71(1.09-2.69)

0.019^*

T stage

1.03(0.73-1.45)

0.086

M stage

1.83(0.80-4.16)

0.150^*

N stage

0.69(0.34-1.38)

0.292

GUCY1A2

1.76(1.20-2.56)

0.004^*