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World Journal of Dental Sciences and Research
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  5. Volume 1, Number 1, 2022
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  7. Table 2

Biological Effects and Molecular Mechanisms of Platelet-Rich Plasma on Periodontal Bone Regeneration

Table 2.

Molecular mechanism ofgrowth factor released by PRP on periodontal bone regeneration

Key Growth factors

Cell membrane receptor

Molecular mechanism

PDGF[63-64]

PGEFR

Activating PI3K induced downstream gene transductions, regulating cell movement and inhibiting apoptosis.

Improved cell mitogenic, proliferation, migration, including MSCs, osteoblasts, fibroblasts, periodontal ligament cell.

VEGF[65-66]

VEGFR

Promoted angiogenesis and osteogenesis in osteoblasts.

Improved mitogen of vascular endothelial cells, and differentiation of adipocytes.

FGF2[67-68]

FGF2R

Activating downstream signal transduction.

Improved angiogenesis and mitogenic.

Increased proliferation and differentiation of BMSC, and osteoblasts.

IGF-1 [69-70]

IGF-1R

Activating downstream signal transduction cascades.

PI3K-Akt triggers to activate transcription factor NF-κB.

Increased alkaline phosphatase, osteopontin and osteocalcin.

Induced proliferation and differentiation on osteoblasts.

EGF [71-72]

EGFR,

PDGFR

Control proinflammatory signaling to modulate proliferation in BMSC.

Regulated cell growth, proliferation and differentiation.

TGF-β [73-74]

TGF-β1, TGF-β2

Regulate osteoblastic and adipogenic differentiation.

Improved proliferation of pre-osteoblasts and fibroblasts.

Stimulate growth of fibroblasts and osteoblasts.

Abbreviations: PDGFR, Platelet-derived growth factor receptor; VEGFR, Vascular endothelial growth factor receptor; FGFR, Fibroblast growth factor receptor;IGF1R, Insulin-like growth factor-1 receptor; EGFR, Epidermal growth factor receptor; TGFβR, Transforming growth factor β receptor; MSC, Mesenchymal stem cells; BMSC, bone marrow stromal cells.
Abbreviations: PDGFR, Platelet-derived growth factor receptor; VEGFR, Vascular endothelial growth factor receptor; FGF2R, Fibroblast growth factor receptor;IGF-1R, Insulin-like growth factor-1 receptor; EGFR, Epidermal growth factor receptor; TGF-βR, Transforming growth factor β receptor; MSCs, Mesenchymal stem cells; BMSC, bone marrow stromal cells.