Open Journal of Medical Sciences

Journal profile

Open Journal of Medical Sciences(OJMS) is an international, peer-reviewed, open access, scientific journal, providing a platform for advances in basic, translational and clinical research. The journal aims to publish original research, review articles and short communications about molecular and cellular processes in disease, in order to increase understanding of the fundamental principles and biological questions of medicine. Researchers in academic and clinical settings as well as health professionals are encouraged to publish their theoretical and experimental results in this journal, which aims to integrate expertise from the molecular and translational sciences, therapeutics, and diagnostics in different medical specialties.

Latest Articles

Open Access May 13, 2024 Endnote/Zotero/Mendeley (RIS) BibTeX

Use of chlorhexidine-impregnated dressings and early catheter exchange to reduce the onset of central line-associated bloodstream infections: A case-control study in a cardiac intensive care unit

Open Journal of Medical Sciences 2024, 4(1), 6-9. DOI: 10.31586/ojms.2024.941
Abstract
Central line-associated bloodstream infections (CLABSIs) are important hospital-acquired infections that are related to increased mortality in cardiac intensive care units (CICUs). To determine the risk factors for CLABSIs, a case-control study was conducted in the CICU of our hospital. Emergency surgery (odds ratio: 9.6, 95% confidence interval: 1.633-56.926) was the
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Central line-associated bloodstream infections (CLABSIs) are important hospital-acquired infections that are related to increased mortality in cardiac intensive care units (CICUs). To determine the risk factors for CLABSIs, a case-control study was conducted in the CICU of our hospital. Emergency surgery (odds ratio: 9.6, 95% confidence interval: 1.633-56.926) was the strongest risk factor comparing the case group (n=11) to the control group (n=22). In addition, the indwelling period was significantly longer in the case group than in the control group (median 9 days versus 7 days, p=0.004). An intervention for the insertion of central lines was then started, with 1) thorough use of chlorhexidine-impregnated dressings (also known as chlorhexidine patches, CHG patches) in the insertion of central lines before emergency surgery, and 2) exchange of the central line 7 days after emergency surgery. After the intervention, the CLABSI incidence rate decreased from 6.8 to 0.8/1,000 device-days. These data suggest the usefulness of CHG patches and the importance of the early exchange of central lines in the CICU in patients following emergency surgery.Full article
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Note
Open Access January 4, 2024 Endnote/Zotero/Mendeley (RIS) BibTeX

Cap-dependent endonuclease inhibitors for adult patients with influenza: the use of baloxavir marboxil

Open Journal of Medical Sciences 2024, 4(1), 1-5. DOI: 10.31586/ojms.2024.852
Abstract
Baloxavir marboxil (BXM) is a novel anti-influenza agent that developed in Japan and inhibit the cap endonuclease specifically, and suggested the more clinical effectiveness in influenza. BXM reduces viral shedding more than do neuraminidase inhibitors (NAIs), and its clinical efficacy is equivalent to that of NAIs but is superior to
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Baloxavir marboxil (BXM) is a novel anti-influenza agent that developed in Japan and inhibit the cap endonuclease specifically, and suggested the more clinical effectiveness in influenza. BXM reduces viral shedding more than do neuraminidase inhibitors (NAIs), and its clinical efficacy is equivalent to that of NAIs but is superior to that of NAIs in the case of type B influenza. BXM does not demonstrate any issues with safety, and treatment with BXM reduces the incidences of complicating sinusitis and bronchitis. Prophylactic administration of BXM inhibits intrafamilial transmission of influenza although low susceptible viruses with a PA/I38X substitution are isolated with a certain frequency following administration of BXM. Finally, In influenza treatment for patients aged 12−19 years and for adult outpatients, BXM can be used with the same recommendation level as oseltamivir.Full article
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Mini Review
Open Access November 22, 2023 Endnote/Zotero/Mendeley (RIS) BibTeX

Pregnancy outcome in patients with previous infection with COVID-19 and the health of newborns

Open Journal of Medical Sciences 2023, 3(1), 46-52. DOI: 10.31586/ojms.2023.823
Abstract
The study is a follow-up of the study "Coronavirus in pregnant patients and their clinical outcomes – results of a case-control study" conducted by R.Kadriu et al (2023) in which,in addition to the pregnant patients whose outcome is now being investigated,a control group of patients who were not pregnant,conducted with
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The study is a follow-up of the study "Coronavirus in pregnant patients and their clinical outcomes – results of a case-control study" conducted by R.Kadriu et al (2023) in which,in addition to the pregnant patients whose outcome is now being investigated,a control group of patients who were not pregnant,conducted with pregnant patients and a control group that were non-pregnant patients.This study was conducted 6 months after the discharge of the patients and their newborns,and highlights the impact of COVID-19 on their health as well as the health of the newborns. The aim of the study is to follow up the patients after 6 months of their hospitalization as COVID-19 patients and after their delivery.In the COVID study, none of the health indicators showed statistically significant differences between the population before and after hospitalization.Patient data were collected at the case level summarized in their respective groups.For secondary objectives, several comparative analyzes were performed regarding comorbidity-related parameters and available risk factors.A significance level (α) of 0.05 was used for statistical significance. While these results may be reassuring regarding the stability of health status, one should be aware of the limitations of the study, including sample size and specific population characteristics.Full article
Article
Open Access November 1, 2023 Endnote/Zotero/Mendeley (RIS) BibTeX

Efficacy and Safety of Long-Term Anticoagulation Therapy with Direct Oral Anticoagulants versus Vitamin K Antagonist in Patients with Cerebral Venous Thrombosis

Open Journal of Medical Sciences 2023, 3(1), 39-45. DOI: 10.31586/ojms.2023.808
Abstract
Introduction: Cerebral venous thrombosis is a rare type of stroke caused by partial or complete occlusion of cerebral venous sinuses. Current guidelines recommend the administration of Low Molecular Weight Heparin (LMWH) during the acute phase and oral Vitamin K antagonists (VKAs) such as warfarin for 3-12 months. Direct Oral Anticoagulants
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Introduction: Cerebral venous thrombosis is a rare type of stroke caused by partial or complete occlusion of cerebral venous sinuses. Current guidelines recommend the administration of Low Molecular Weight Heparin (LMWH) during the acute phase and oral Vitamin K antagonists (VKAs) such as warfarin for 3-12 months. Direct Oral Anticoagulants (DOACs) are an attractive alternative to VKAs as therapy for CVT, for its safety and efficacy as anticoagulation therapy for deep venous thrombosis or pulmonary embolism. Method: This systematic review is written based on PRISMA guidelines with electronic search performed on various databases for journals published from June 1, 2018 to June 1, 2023. Results: We found four studies fulfilling the inclusion criteria, with four randomized controlled studies presenting 179 CVT patients treated with DOAC and 150 patients treated with standard therapy. DOACs used in reviewed studies are Dabigatran and Rivaroxaban. Discussion: Administration of DOACs as anticoagulation therapy in patients with CVT presents better recanalization rate with no significant differences in efficacy compared with VKAs, along with a better safety profile through similar mortality rate across two groups. Conclusion: DOACs as long-term anticoagulation therapy in patients with CVT has better efficacy along with a similar safety profile compared to VKA.Full article
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Systematic Review
Open Access February 2, 2023 Endnote/Zotero/Mendeley (RIS) BibTeX

Quantifying 64 drugs, illicit substances, and D- and L- isomers in human oral fluid with liquid-liquid extraction

Open Journal of Medical Sciences 2023, 3(1), 1-38. DOI: 10.31586/ojms.2023.591
Abstract
Although human oral fluid has become more routine for quantitative drug detection in pain management, detecting a large scope of medications and substances is costly and technically challenging for laboratories. This paper presents a quantitative assay for 64 pain medications, illicit substances, and drug metabolites in human oral fluid. The
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Although human oral fluid has become more routine for quantitative drug detection in pain management, detecting a large scope of medications and substances is costly and technically challenging for laboratories. This paper presents a quantitative assay for 64 pain medications, illicit substances, and drug metabolites in human oral fluid. The novelty of this assay is that it was developed on an older model AB SCIEX 4000 instrument and renders obscure the need for more technical and expensive laboratory equipment. This method includes addition of internal standard and a 2-step liquid-liquid extraction and dry-down step to concentrate and clean the samples. The samples were suspended in 50% MeOH in water and separation and detection was accomplished using triple quadrupole mass spectrometry (LC-MS/MS). Separation was achieved using reverse-phase liquid chromatography with detection by LC-MS/MS. A second injection was done in negative mode to determine THC-COOH concentration as an indicator of THC. An aliquot of the (already) extracted samples was analyzed for D- and L- isomers of amphetamine and methamphetamine using a chiral column. The standard curve spanned from 5 to 2000 ng/mL for most of the analytes (1 to 2000 ng/mL for fentanyl and THC-COOH) and up to 1000 ng/mL for 13 analytes. Pregabalin and gabapentin ranged from 25 to 2000 ng/mL. The result is a low-cost method for the sensitive detection of a wide-ranging oral fluid menu for pain management. This assay has a high sensitivity, and good precision and accuracy for all analytes with an older model mass spectrometer.Full article
Article
Open Access December 14, 2022 Endnote/Zotero/Mendeley (RIS) BibTeX

Clinical Approach to Diagnosing and Treatment of Neck Pain

Open Journal of Medical Sciences 2022, 2(1), 17-23. DOI: 10.31586/ojms.2022.526
Abstract
Background: Neck pain is one of the most common reasons patients seek treatment in the hospital. The causes of neck pain vary widely, trigger misdiagnosis, and often result in mistreatment. Misdiagnoses and mistreatment-related neck pain diagnoses are often associated with a diagnosis of cervical herniated disc. The implication of the
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Background: Neck pain is one of the most common reasons patients seek treatment in the hospital. The causes of neck pain vary widely, trigger misdiagnosis, and often result in mistreatment. Misdiagnoses and mistreatment-related neck pain diagnoses are often associated with a diagnosis of cervical herniated disc. The implication of the misdiagnosis is the use of excessive investigations and inappropriate therapy. This review aims to determine the causes of neck pain often obtained in daily practice and how to diagnose and treat it. Method: Search relevant articles on clinical diagnosis of neck pain with the keywords neck pain diagnostic therapy using Medline and PubMed databases. Results: Neck pain can be in the form of axial pain, which is mostly related to disorders of the joints and muscles of the neck, or in the form of pain in the roots and spinal cord. Investigations and therapy must be related to the clinical diagnosis of neck pain experienced by patients with a history of neck pain. Conclusion: Neck pain is one of the most common complaints encountered in outpatient department settings, associated with reduced quality of life. Patients may come with differing degrees of pain, various symptoms, and aetiologies making it quite challenging to treat them into complete remission. Despite being frequently encountered, some patients with neck pain are underdiagnosed and undertreated due to failure to understand the clinical symptoms before deciding possible aetiologies.Full article
Review Article
Open Access October 29, 2022 Endnote/Zotero/Mendeley (RIS) BibTeX

Measurement of conversion factor into mean glandular dose in mammography using OSL dosimeters

Open Journal of Medical Sciences 2022, 2(1), 9-16. DOI: 10.31586/ojms.2022.432
Abstract
Background: Currently, the DRL quantity in mammography are evaluated in terms of mean glandular dose (MGD). Since the MGD cannot be measured directly, it can be obtained by calculation using the equation (D=K*g*c*s). In previous studies, the conversion factor g was calculated by Monte Carlo simulation and is not reported
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Background: Currently, the DRL quantity in mammography are evaluated in terms of mean glandular dose (MGD). Since the MGD cannot be measured directly, it can be obtained by calculation using the equation (D=K*g*c*s). In previous studies, the conversion factor g was calculated by Monte Carlo simulation and is not reported from actual measurements. In this study, we focused on the g-factor, which is a conversion factor to the MGD at 50% glandularity, and attempted to measure it using a nanoDot dosimeter to see if it can be used in mammography. Methods: The nanoDot dosimeters were inserted in a PMMA phantom at depths ranging from 0 cm to 6 cm in 1 cm increments, and measurements were made in three HVLs of 0.3 mmAl, 0.35 mmAl, and 0.4 mmAl HVL. The g-factor was calculated from the nanoDot dosimeter values using a conversion equation. Results and Discussion: The measured g-factors for all the HVLs were in close agreement with those of Dance et al. The values of the previous studies did not include the backscatter factor, which may have underestimated the MGD. The difference was smaller for the 0.4 mm Al. Compared to the other HVLs, the 0.4 mm Al was measured without a compression plate, which may have been influenced by the presence or absence of a compression plate. Conclusion: The nanoDot dosimeters were used to calculate g-factors. The results agreed with those of previous studies within uncertainty. This indicates that nanoDot dosimeters can be used in the mammography field.Full article
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Article
Open Access June 28, 2022 Endnote/Zotero/Mendeley (RIS) BibTeX

A Case Report of Sagittal Sinus Thrombosis and Pulmonary Embolism in an Asymptomatic SARS-CoV-2 Infection

Open Journal of Medical Sciences 2022, 2(1), 5-8. DOI: 10.31586/ojms.2022.280
Abstract
Background: Vascular thrombotic events such as pulmonary embolisms have been frequently reported in the course of SARS-Cov-2 infection. However, sagittal sinus thrombus is extremely rare, and patients may lack other appealing Covid-19 infection symptoms. Case report: 46-year-old female with past medical history of Hyperlipidemia, Hypertension presented to Emergency room with
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Background: Vascular thrombotic events such as pulmonary embolisms have been frequently reported in the course of SARS-Cov-2 infection. However, sagittal sinus thrombus is extremely rare, and patients may lack other appealing Covid-19 infection symptoms. Case report: 46-year-old female with past medical history of Hyperlipidemia, Hypertension presented to Emergency room with headache, chest pain, vomiting. SARS-CoV-2 IgG Antibodies were reactive. Except for elevated PTT-Lupus Anticoagulant at 50 Sec, Hypercoagulable workup was negative. The MRI venogram findings were consistent with the Dural thrombus of superior sagittal sinus. Patient subsequently developed chest pain, and Computed tomography angiography found pulmonary emboli within segmental branches of the right lower lobe pulmonary artery. Patient was managed in the ICU with Heparin and switched to Coumadin for discharged. Conclusion: The incidence of Cerebral Venous Sinus thrombus (CVST) among Covid-19 patients is inferior to 0.02%. And most of the patients lack typical Covid-19 presentations such as pneumonia. The lack of symptoms may promote the insidious course of pre-thrombotic events that lead to CVST. However more Retrospective studies are necessary to established consistent odd ratios. Due to the higher mortality associated with CVST and the ongoing of Covid-19 pandemic, we recommend a higher level of clinical suspicion.Full article
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Case Report
Open Access December 13, 2021 Endnote/Zotero/Mendeley (RIS) BibTeX

Idiopathic Retroperitoneal Fibrosis: A Case of Women 75-years Old Without Ureteral Involvement

Open Journal of Medical Sciences 2022, 2(1), 1-4. DOI: 10.31586/ojms.2022.197
Abstract
A 75-year-old female is referred for evaluation of a progressive leg swelling. Angiological and MRI evaluation show the presence of inflammatory tissue surrounding the aorta and the left iliac vessels, causing significant stenosis. Upon suspicion of retroperitoneal fibrosis, we actively seek for secondary causes such as malignancies, autoimmune diseases and
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A 75-year-old female is referred for evaluation of a progressive leg swelling. Angiological and MRI evaluation show the presence of inflammatory tissue surrounding the aorta and the left iliac vessels, causing significant stenosis. Upon suspicion of retroperitoneal fibrosis, we actively seek for secondary causes such as malignancies, autoimmune diseases and infections, as well as IgG4-related disease. All investigations result negative and we make the diagnosis of idiopathic retroperitoneal fibrosis. Steroid therapy was started and we observed a rapid amelioration of symptoms and radiological disappearance of the inflammatory tissue around the aorta.Full article
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Case Report

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ISSN: 2770-5544
DOI prefix: 10.31586/ojms
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2021-2024
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