Quantifying 64 drugs, illicit substances, and D- and L- isomers in human oral fluid with liquid-liquid extraction

Table 4.

Intra-assay Precision and Accuracy: Precision and Accuracy over 3 days withreplicates of 6 for each day.

Drug / Metabolite

LLOQ

LQC

MQC

HQC

%CV

%E

%CV

%E

%CV

%E

%CV

%E

MIN

MAX

MIN

MAX

MIN

MAX

MIN

MAX

MIN

MAX

MIN

MAX

MIN

MAX

MIN

MAX

6-MAM

9.01

18.07

-15.64

12.17

7.28

13.63

-12.10

4.12

4.86

9.74

-3.09

11.41

2.58

4.71

-0.05

15.12

7-Amino Clonazepam

4.33

9.39

6.00

14.87

5.44

6.65

8.68

12.41

3.32

6.00

-3.03

2.52

3.27

6.43

-1.10

15.50

Alprazolam

8.16

13.14

-11.60

7.20

3.35

8.88

-8.82

7.32

3.12

6.64

-6.64

-1.90

4.77

6.81

1.42

14.77

Amitriptyline*

3.51

11.52

9.13

11.90

4.30

5.39

9.67

14.33

2.06

3.58

-11.29

-7.38

2.46

6.28

-10.36

-3.09

Amphetamine*

2.28

10.19

-2.20

13.20

2.72

5.62

9.07

12.43

2.06

5.57

-5.07

-0.91

3.46

8.89

-5.00

6.59

a-OH Alprazolam

8.82

16.64

-5.43

-1.50

6.06

9.67

-1.69

6.63

3.30

5.94

-1.80

0.36

3.15

7.31

-6.77

1.76

Benzoylecgonine

3.95

10.99

-3.30

17.00

4.07

8.20

6.22

15.23

2.13

3.39

-3.23

-1.16

2.48

5.94

3.38

23.18

Buprenorphine

8.06

17.33

-7.13

10.33

2.54

8.69

2.84

6.02

3.76

6.68

-10.06

3.63

2.14

9.87

-7.80

8.99

Carisoprodol

6.63

10.14

-2.07

17.70

6.03

9.21

1.10

11.82

3.99

4.47

-16.33

-5.62

3.79

5.61

-11.33

1.84

Chlordiazepoxide*

3.55

10.32

8.03

10.73

2.62

3.99

5.66

11.91

2.62

3.58

-2.90

7.70

1.55

3.97

-4.65

-0.60

Clonazepam

2.17

7.66

-17.17

19.65

4.59

10.69

-12.53

8.71

2.52

7.67

-8.92

6.07

1.01

3.80

1.65

7.30

Codeine

5.91

14.73

-12.08

3.07

6.84

9.35

-3.67

13.09

7.06

10.54

-14.33

10.37

2.72

13.64

-8.97

18.21

Cotinine

1.06

3.97

0.77

9.03

0.85

2.21

0.33

6.51

1.79

3.14

-2.90

-0.74

2.57

3.04

1.37

7.69

Cyclobenzaprine

10.47

19.32

-15.93

5.40

5.85

8.78

-5.98

6.97

2.48

3.82

-4.49

2.69

2.10

3.45

-3.46

6.03

Desalkylflurazepam

5.97

8.27

-8.63

6.70

5.69

13.22

-3.92

12.83

4.34

6.04

-8.98

7.65

2.60

5.00

-1.48

15.23

Desipramine

5.16

7.14

8.00

11.50

2.18

7.35

4.69

9.53

1.28

7.21

-13.39

-1.22

2.75

3.75

-1.82

9.98

Diazepam

3.25

5.61

-0.30

6.30

3.58

8.12

1.24

13.38

2.11

4.41

-5.58

9.68

5.38

11.58

3.58

23.59

Dihydrocodeine

10.04

16.88

-9.40

12.63

7.98

13.09

-7.00

-1.78

4.84

10.52

-13.49

-10.99

4.55

9.20

-3.55

9.85

Doxepin

7.00

12.15

0.10

7.27

4.92

5.47

2.13

8.61

2.31

4.47

-4.49

0.38

2.80

6.07

4.07

5.02

EDDP

5.06

6.14

-7.17

1.37

4.29

9.80

-5.34

1.72

2.75

3.37

-16.90

-8.59

3.09

4.92

-14.97

-0.45

Fentanyl

14.53

23.15

-26.75

1.67

7.03

8.83

-4.89

4.33

1.46

3.85

-8.80

-0.24

3.00

4.70

-5.22

2.49

Fluoxetine

5.24

14.21

3.50

8.33

2.79

5.22

6.56

8.46

3.20

5.05

-8.42

1.90

5.71

7.03

-9.96

10.59

Gabapentin

4.76

17.33

4.87

19.29

6.99

13.05

-15.95

13.29

6.74

12.49

-16.17

19.80

6.23

11.44

-11.32

6.27

Hydrocodone

10.55

17.43

5.43

14.00

5.47

11.96

-1.69

17.42

4.70

5.19

-13.60

7.84

1.50

6.96

-4.02

0.16

Hydromorphone

8.91

16.26

-5.57

12.17

10.45

12.60

-6.96

-2.01

4.86

18.92

-11.73

11.41

2.58

13.75

-2.49

15.12

Imipramine

9.76

16.92

-7.60

4.20

2.18

12.02

-0.97

0.73

1.41

4.14

-0.82

11.93

2.37

4.76

5.43

18.80

Ketamine*

4.93

7.35

1.93

15.50

6.04

6.77

8.97

10.61

3.43

4.18

-18.13

-1.77

3.65

5.77

-19.13

1.71

Lorazepam

1.11

16.90

-7.33

13.15

4.27

11.16

0.73

8.02

3.08

3.64

-8.77

-2.71

3.59

7.28

-4.13

8.19

MDA*

9.43

11.52

-4.93

13.07

5.30

11.03

4.78

10.87

3.40

9.79

0.09

2.31

2.21

4.70

1.37

8.37

MDMA

5.74

8.93

-7.23

4.70

3.36

8.15

-9.64

2.56

3.15

5.42

-17.29

-4.25

3.84

6.78

-12.90

5.72

MDPV

3.00

11.27

4.93

8.77

4.60

6.19

-2.82

10.82

4.20

4.86

-2.45

3.66

2.27

6.38

-0.25

13.82

Meperidine*

1.20

5.32

-0.20

9.53

1.82

3.58

1.72

9.02

1.48

5.68

-6.50

-1.04

1.21

4.51

-5.16

-2.42

Meprobamate

3.72

10.44

1.83

10.83

2.06

6.39

1.39

5.50

2.61

4.33

-5.00

-1.06

2.69

4.46

2.27

9.30

Methadone

5.26

8.68

2.30

8.97

1.50

3.98

11.96

16.42

2.61

9.74

-13.82

2.85

3.92

4.42

-12.79

0.10

Methamphetamine

4.84

9.89

-2.60

7.53

1.71

4.41

-0.02

1.66

1.71

2.92

-6.31

2.48

2.10

4.41

-2.22

6.50

Methylphenidate*

5.07

6.05

9.07

13.60

2.18

4.86

7.54

14.90

1.70

2.49

-7.45

1.52

2.30

4.58

-2.83

0.27

Morphine

9.36

13.19

0.30

13.63

8.05

10.54

-1.54

21.87

6.05

8.83

-17.22

4.53

7.02

9.10

-10.99

9.15

Naloxone

6.04

13.40

-1.03

12.70

10.16

14.14

-4.99

12.33

6.59

8.14

-7.62

1.54

2.47

8.16

-8.08

-3.20

Naltrexone

9.68

15.15

-3.23

11.84

8.31

11.20

-0.04

8.54

4.11

6.59

-7.70

-1.60

4.79

11.07

-0.44

8.19

Nicotine

2.98

6.09

-4.40

5.10

1.49

3.80

-0.34

6.23

2.27

4.29

-5.74

3.74

1.67

4.22

-3.38

14.85

Norbuprenorphine

6.96

10.42

-11.27

5.90

5.11

8.76

-4.94

7.59

2.29

4.50

-2.15

-0.41

3.79

10.56

-2.01

3.85

Nordiazepam

5.19

9.95

-11.03

-1.33

4.88

14.06

-2.36

9.71

5.30

6.07

-10.87

1.56

3.79

5.86

-4.57

5.71

Norfentanyl

7.81

11.01

0.43

10.50

8.97

11.84

6.40

15.21

6.26

9.54

-1.92

6.44

5.62

8.23

-7.19

-0.09

Norhydrocodone

5.68

15.60

0.40

6.60

9.43

13.18

-0.61

13.97

7.21

11.23

1.61

9.54

6.06

7.61

-8.22

0.31

Norketamine

6.55

8.72

-3.83

6.40

6.17

9.01

-9.44

5.31

3.55

4.31

-9.08

2.41

2.00

4.92

-6.43

-0.59

Noroxycodone

14.45

16.73

-2.60

7.83

4.43

13.35

8.29

12.28

5.20

16.90

-13.54

5.18

2.07

6.97

-7.78

-1.00

Noroxymorphone

9.38

17.85

3.73

16.33

7.28

12.74

4.22

12.24

2.88

3.33

3.52

11.98

2.55

7.08

-3.14

3.01

Nortriptyline

7.12

7.15

-1.83

4.57

3.51

5.52

-11.40

11.44

2.75

2.84

-19.93

-2.58

2.62

4.18

-18.75

11.08

O-desmethyl Tramadol

3.44

9.99

6.50

13.87

2.60

9.77

3.96

12.03

5.08

6.01

-10.35

-3.76

5.12

6.36

-1.97

0.52

Oxazepam

4.77

7.79

5.20

8.43

2.35

3.72

10.57

16.98

2.30

5.13

-3.76

-1.67

2.31

2.45

3.73

7.78

Oxycodone

8.27

9.76

-11.23

6.23

6.54

11.45

-5.59

3.09

6.01

10.16

-10.54

0.54

3.27

4.99

-7.15

-1.19

Oxymorphone

9.91

16.05

-4.40

8.20

7.73

14.01

-5.56

7.19

4.31

7.44

-6.06

-1.90

3.63

5.86

-0.68

2.38

Paroxetine

7.68

16.21

8.97

11.40

2.16

6.44

8.13

12.07

2.93

3.31

-7.27

-3.22

4.36

10.92

-3.71

7.83

Phencyclidine

6.58

15.72

-9.23

4.50

4.55

7.46

-8.27

-1.21

2.84

3.94

-8.09

-1.38

3.25

4.47

-0.81

3.88

Pregabalin

11.84

17.10

-1.53

10.89

8.00

17.30

-7.30

14.20

9.76

17.69

-10.64

0.72

5.82

15.67

-7.15

-0.35

Ritalinic Acid*

2.91

16.92

-7.03

22.63

4.01

12.30

-0.56

12.41

4.22

14.76

-8.74

1.37

3.68

4.52

-3.08

-1.18

Tapentadol

1.94

10.80

-1.73

7.03

3.82

5.42

-1.72

12.80

1.62

5.14

-7.71

-0.41

2.72

3.87

2.32

5.17

Temazepam

5.27

12.57

-15.80

9.80

4.85

7.18

6.83

27.88

1.15

2.54

-2.14

7.89

1.32

4.02

-7.81

7.95

Tramadol

3.94

8.92

-5.03

11.77

4.73

5.09

4.71

10.89

2.47

4.92

-6.52

-3.37

3.58

5.70

-3.08

-1.10

Venlafaxine

5.86

7.08

-10.10

10.27

1.70

2.82

5.80

8.38

3.01

5.73

-14.40

-1.74

1.86

2.84

-5.99

-0.86

Zaleplon

4.79

6.74

1.67

9.77

0.91

6.98

5.97

13.88

4.74

6.08

-5.49

1.63

4.94

14.24

-13.41

5.24

Zolpidem

2.24

5.12

-1.43

4.43

2.48

3.48

0.82

6.28

1.08

2.64

-7.17

-0.79

1.26

3.41

-1.48

7.09

Zopiclone

4.44

9.90

6.57

10.10

7.13

8.32

-3.02

12.93

3.98

7.60

-13.09

6.17

2.66

3.99

-3.07

4.84

THC-COOH

5.20

7.38

-17.50

5.17

3.82

10.03

-13.78

4.94

2.67

6.62

-6.60

20.04

1.18

8.33

-4.49

6.79

D-Amphetamine

1.38

3.51

8.44

15.79

1.14

1.40

4.38

15.69

0.69

1.73

-2.89

-0.02

1.46

2.99

0.75

7.90

L-Amphetamine

2.60

4.47

6.63

13.33

1.11

1.79

9.38

15.71

1.14

1.57

-3.13

0.31

1.46

2.33

-5.16

0.02

D-Methamphetamine

1.28

4.42

-1.56

5.73

1.67

2.66

-3.19

4.96

1.75

2.21

-4.28

4.24

1.67

2.74

7.59

17.89

L-Methamphetamine

1.66

5.19

-2.83

7.65

2.59

3.56

-3.14

6.69

0.55

0.99

-4.74

7.49

2.17

5.87

8.68

17.91

Lower limit of Quantitation (LLOQ), Low Quality Control (LQC), Mid Quality Control (MQC), High Quality Control (HQC), Percent Coefficient of Variability(%CV), Percent error (%E)

Lower limit of Quantitation (LLOQ), Low Quality Control (LQC), Mid Quality Control (MQC), High Quality Control (HQC), Percent Coefficient of Variability(%CV), Percent error (%E)