Quantifying 64 drugs, illicit substances, and D- and L- isomers in human oral fluid with liquid-liquid extraction
Table 5.
Dilution study
| Drug / Metabolite | 1:5 Dilution | 1:10 Dilution | 1:20 Dilution | 1: 50 Dilution | | 6-MAM | -0.16 | 4.57 | 7.30 | 18.55 | | 7-Amino Clonazepam | -36.28 | 6.40 | 38.67 | 53.62 | | Alprazolam | 2.18 | 4.06 | 6.52 | 14.43 | | Amitriptyline | -1.67 | -2.67 | 5.22 | 5.53 | | Amphetamine | 1.03 | 4.04 | 9.45 | 12.00 | | a-OH Alprazolam | 5.90 | -2.30 | 2.44 | 2.89 | | Benzoylecgonine | -5.43 | 1.31 | 8.61 | 8.54 | | Buprenorphine | -6.65 | -14.20 | 2.54 | -0.63 | | Carisoprodol | -11.43 | -4.02 | 13.36 | 11.79 | | Chlordiazepoxide | -19.90 | -19.40 | -18.54 | -15.39 | | Clonazepam | 5.46 | 4.05 | 19.52 | 37.10 | | Codeine | 17.35 | -3.71 | 14.86 | 11.43 | | Cotinine | -5.45 | 0.83 | 2.74 | 5.43 | | Cyclobenzaprine | -2.94 | 2.76 | 5.31 | 6.05 | | Desalkylflurazepam | 9.80 | 14.02 | 19.80 | 38.83 | | Desipramine | -0.64 | 6.75 | 9.89 | 18.24 | | Diazepam | -6.73 | 1.28 | 11.79 | 11.53 | | Dihydrocodeine | -0.35 | 17.71 | 16.90 | 1.06 | | Doxepin | -8.03 | -0.39 | 0.35 | 0.33 | | EDDP | -3.36 | 1.50 | 10.73 | 7.68 | | Fentanyl | 1.10 | 4.63 | 10.09 | 8.80 | | Fluoxetine | -7.13 | 4.62 | 16.67 | 6.59 | | Gabapentin | -2.80 | 9.41 | -7.22 | 14.08 | | Hydrocodone | 2.28 | 7.31 | -4.46 | -5.21 | | Hydromorphone | -1.26 | 4.34 | -1.52 | 3.21 | | Imipramine | -1.69 | 5.93 | 0.61 | 7.07 | | Ketamine* | -19.27 | -11.18 | 7.96 | 9.94 | | Lorazepam | 8.57 | 3.42 | 0.57 | 12.08 | | MDA | -0.64 | 9.12 | 10.55 | 3.46 | | MDMA | -1.71 | 5.78 | 12.68 | 11.55 | | MDPV | -0.90 | 1.54 | 5.01 | 7.49 | | Meperidine | -13.29 | -6.57 | 4.29 | 3.09 | | Meprobamate | -9.67 | -5.32 | 4.19 | 10.96 | | Methadone | -10.62 | -6.74 | 1.05 | 10.66 | | Methamphetamine | -8.17 | -0.32 | 3.13 | 0.66 | | Methylphenidate | -10.14 | 2.33 | 12.03 | 10.16 | | Morphine | -4.01 | 6.04 | 12.40 | -5.21 | | Naloxone | -8.69 | -8.42 | 2.11 | 4.82 | | Naltrexone | -9.13 | -7.98 | -1.48 | -10.93 | | Nicotine | -15.97 | -3.19 | 6.03 | 11.19 | | Norbuprenorphine | -0.81 | 3.18 | 3.58 | 2.05 | | Nordiazepam | 9.56 | 7.98 | 13.45 | 11.26 | | Norfentanyl | 7.91 | 3.21 | 15.30 | -9.30 | | Norhydrocodone | 1.74 | -11.65 | 2.28 | 12.83 | | Norketamine | -0.22 | 9.12 | 12.49 | 8.15 | | Noroxycodone | -5.03 | 1.66 | 4.82 | -3.80 | | Noroxymorphone | 5.26 | 9.62 | 1.51 | 1.76 | | Nortriptyline | -7.43 | -0.14 | 13.26 | -1.04 | | O-desmethyl Tramadol | -4.43 | -8.07 | 0.72 | -3.05 | | Oxazepam | 19.47 | 7.29 | 23.86 | 42.76 | | Oxycodone | 1.20 | -8.02 | -3.54 | -13.84 | | Oxymorphone | -2.77 | -0.28 | 11.92 | -1.13 | | Paroxetine | -0.71 | 3.11 | 11.10 | 11.24 | | Phencyclidine | -0.42 | 8.96 | 11.32 | 16.31 | | Pregabalin | 14.26 | -15.73 | 11.47 | 4.97 | | Ritalinic Acid | -10.16 | -3.28 | 1.11 | 2.24 | | Tapentadol | 0.23 | 6.90 | 11.11 | 14.75 | | Temazepam | 58.41 | 17.55 | 166.96 | 224.88 | | Tramadol | 4.37 | 2.03 | 1.03 | -1.49 | | Venlafaxine | -10.77 | -3.33 | -0.19 | 1.64 | | Zaleplon | -6.99 | -0.31 | 7.43 | 12.99 | | Zolpidem | -4.15 | 1.43 | 5.19 | 14.15 | | Zopiclone | -4.34 | 4.16 | 8.36 | 10.70 | | THC-COOH | 8.33 | 19.53 | -8.44 | 7.74 | | D-Amphetamine | 2.38 | 5.97 | 9.87 | 12.19 | | L-Amphetamine | 2.56 | 7.39 | 10.81 | 9.60 | | D-Methamphetamine | -0.51 | -3.58 | -1.77 | -3.63 | | L-Methamphetamine | 3.89 | 1.00 | 5.46 | 3.87 | Note: All analytes based at a 1:10 dilution. Percent difference from expected with a 4000 ng/mL standard diluted as indicated.
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Note: All analytes based at a 1:10 dilution. Percent difference from expected with a 4000 ng/mL standard diluted as indicated. |