Quantifying 64 drugs, illicit substances, and D- and L- isomers in human oral fluid with liquid-liquid extraction

Table 5.

Dilution study

Drug / Metabolite

1:5 Dilution

1:10 Dilution

1:20 Dilution

1: 50 Dilution

6-MAM

-0.16

4.57

7.30

18.55

7-Amino Clonazepam

-36.28

6.40

38.67

53.62

Alprazolam

2.18

4.06

6.52

14.43

Amitriptyline

-1.67

-2.67

5.22

5.53

Amphetamine

1.03

4.04

9.45

12.00

a-OH Alprazolam

5.90

-2.30

2.44

2.89

Benzoylecgonine

-5.43

1.31

8.61

8.54

Buprenorphine

-6.65

-14.20

2.54

-0.63

Carisoprodol

-11.43

-4.02

13.36

11.79

Chlordiazepoxide

-19.90

-19.40

-18.54

-15.39

Clonazepam

5.46

4.05

19.52

37.10

Codeine

17.35

-3.71

14.86

11.43

Cotinine

-5.45

0.83

2.74

5.43

Cyclobenzaprine

-2.94

2.76

5.31

6.05

Desalkylflurazepam

9.80

14.02

19.80

38.83

Desipramine

-0.64

6.75

9.89

18.24

Diazepam

-6.73

1.28

11.79

11.53

Dihydrocodeine

-0.35

17.71

16.90

1.06

Doxepin

-8.03

-0.39

0.35

0.33

EDDP

-3.36

1.50

10.73

7.68

Fentanyl

1.10

4.63

10.09

8.80

Fluoxetine

-7.13

4.62

16.67

6.59

Gabapentin

-2.80

9.41

-7.22

14.08

Hydrocodone

2.28

7.31

-4.46

-5.21

Hydromorphone

-1.26

4.34

-1.52

3.21

Imipramine

-1.69

5.93

0.61

7.07

Ketamine*

-19.27

-11.18

7.96

9.94

Lorazepam

8.57

3.42

0.57

12.08

MDA

-0.64

9.12

10.55

3.46

MDMA

-1.71

5.78

12.68

11.55

MDPV

-0.90

1.54

5.01

7.49

Meperidine

-13.29

-6.57

4.29

3.09

Meprobamate

-9.67

-5.32

4.19

10.96

Methadone

-10.62

-6.74

1.05

10.66

Methamphetamine

-8.17

-0.32

3.13

0.66

Methylphenidate

-10.14

2.33

12.03

10.16

Morphine

-4.01

6.04

12.40

-5.21

Naloxone

-8.69

-8.42

2.11

4.82

Naltrexone

-9.13

-7.98

-1.48

-10.93

Nicotine

-15.97

-3.19

6.03

11.19

Norbuprenorphine

-0.81

3.18

3.58

2.05

Nordiazepam

9.56

7.98

13.45

11.26

Norfentanyl

7.91

3.21

15.30

-9.30

Norhydrocodone

1.74

-11.65

2.28

12.83

Norketamine

-0.22

9.12

12.49

8.15

Noroxycodone

-5.03

1.66

4.82

-3.80

Noroxymorphone

5.26

9.62

1.51

1.76

Nortriptyline

-7.43

-0.14

13.26

-1.04

O-desmethyl Tramadol

-4.43

-8.07

0.72

-3.05

Oxazepam

19.47

7.29

23.86

42.76

Oxycodone

1.20

-8.02

-3.54

-13.84

Oxymorphone

-2.77

-0.28

11.92

-1.13

Paroxetine

-0.71

3.11

11.10

11.24

Phencyclidine

-0.42

8.96

11.32

16.31

Pregabalin

14.26

-15.73

11.47

4.97

Ritalinic Acid

-10.16

-3.28

1.11

2.24

Tapentadol

0.23

6.90

11.11

14.75

Temazepam

58.41

17.55

166.96

224.88

Tramadol

4.37

2.03

1.03

-1.49

Venlafaxine

-10.77

-3.33

-0.19

1.64

Zaleplon

-6.99

-0.31

7.43

12.99

Zolpidem

-4.15

1.43

5.19

14.15

Zopiclone

-4.34

4.16

8.36

10.70

THC-COOH

8.33

19.53

-8.44

7.74

D-Amphetamine

2.38

5.97

9.87

12.19

L-Amphetamine

2.56

7.39

10.81

9.60

D-Methamphetamine

-0.51

-3.58

-1.77

-3.63

L-Methamphetamine

3.89

1.00

5.46

3.87

Note: All analytes based at a 1:10 dilution. Percent difference from expected with a 4000 ng/mL standard diluted as indicated.

Note: All analytes based at a 1:10 dilution. Percent difference from expected with a 4000 ng/mL standard diluted as indicated.