Quantifying 64 drugs, illicit substances, and D- and L- isomers in human oral fluid with liquid-liquid extraction

Table 7.

Matrix effects and recovery

Matrix Comparison

Matrix Comparison

Drug / Metabolite

%CV Analyte/IS ratio

Drug / Metabolite

%CV Analyte/IS ratio

6-MAM

8.81

Methamphetamine

4.60

7-Amino Clonazepam

8.07

Methylphenidate*

3.45

Alprazolam

4.93

Morphine

10.44

Amitriptyline

5.12

Naloxone

7.88

Amphetamine

3.39

Naltrexone

6.78

a-OH Alprazolam

4.47

Nicotine

5.26

Benzoylecgonine

5.92

Norbuprenorphine

5.29

Buprenorphine

5.10

Nordiazepam

4.60

Carisoprodol

4.89

Norfentanyl

8.78

Chlordiazepoxide

3.21

Norhydrocodone

8.62

Clonazepam

4.68

Norketamine

5.50

Codeine

11.05

Noroxycodone

10.41

Cotinine

2.26

Noroxymorphone

10.95

Cyclobenzaprine

3.71

Nortriptyline

3.63

Desalkylflurazepam

7.75

O-desmethyl Tramadol

5.27

Desipramine

4.87

Oxazepam

2.89

Diazepam

4.21

Oxycodone

9.24

Dihydrocodeine

8.82

Oxymorphone

6.63

Doxepin

3.02

Paroxetine

9.65

EDDP

4.09

Phencyclidine

5.15

Fentanyl

3.12

Pregabalin

17.52

Fluoxetine

5.33

Ritalinic Acid*

16.03

Gabapentin

13.88

Tapentadol

4.74

Hydrocodone

10.52

Temazepam

3.32

Hydromorphone

12.29

Tramadol*

4.61

Imipramine

4.60

Venlafaxine

2.88

Ketamine

6.11

Zaleplon

3.76

Lorazepam

3.93

Zolpidem

3.76

MDA

6.76

Zopiclone

8.40

MDMA

4.36

THC-COOH

8.14

MDPV

5.65

D-Amphetamine

1.59

Meperidine

2.84

L-Amphetamine

2.35

Meprobamate

3.94

D-Methamphetamine

7.54

Methadone

3.93

L-Methamphetamine

3.09

Note: Ten different lots of oral fluid fortified with QC material to a concentration of 75 ng/mL and the %CV determined of the analyte per internal standard area ratio

Note: Ten different lots of oral fluid fortified with QC material to a concentration of 75 ng/mL and the %CV determined of the analyte per internal standard area ratio