Quantifying 64 drugs, illicit substances, and D- and L- isomers in human oral fluid with liquid-liquid extraction
Table 7.
Matrix effects and recovery
| Matrix Comparison | | Matrix Comparison | | Drug / Metabolite | %CV Analyte/IS ratio | Drug / Metabolite | %CV Analyte/IS ratio | | 6-MAM | 8.81 | Methamphetamine | 4.60 | | 7-Amino Clonazepam | 8.07 | Methylphenidate* | 3.45 | | Alprazolam | 4.93 | Morphine | 10.44 | | Amitriptyline | 5.12 | Naloxone | 7.88 | | Amphetamine | 3.39 | Naltrexone | 6.78 | | a-OH Alprazolam | 4.47 | Nicotine | 5.26 | | Benzoylecgonine | 5.92 | Norbuprenorphine | 5.29 | | Buprenorphine | 5.10 | Nordiazepam | 4.60 | | Carisoprodol | 4.89 | Norfentanyl | 8.78 | | Chlordiazepoxide | 3.21 | Norhydrocodone | 8.62 | | Clonazepam | 4.68 | Norketamine | 5.50 | | Codeine | 11.05 | Noroxycodone | 10.41 | | Cotinine | 2.26 | Noroxymorphone | 10.95 | | Cyclobenzaprine | 3.71 | Nortriptyline | 3.63 | | Desalkylflurazepam | 7.75 | O-desmethyl Tramadol | 5.27 | | Desipramine | 4.87 | Oxazepam | 2.89 | | Diazepam | 4.21 | Oxycodone | 9.24 | | Dihydrocodeine | 8.82 | Oxymorphone | 6.63 | | Doxepin | 3.02 | Paroxetine | 9.65 | | EDDP | 4.09 | Phencyclidine | 5.15 | | Fentanyl | 3.12 | Pregabalin | 17.52 | | Fluoxetine | 5.33 | Ritalinic Acid* | 16.03 | | Gabapentin | 13.88 | Tapentadol | 4.74 | | Hydrocodone | 10.52 | Temazepam | 3.32 | | Hydromorphone | 12.29 | Tramadol* | 4.61 | | Imipramine | 4.60 | Venlafaxine | 2.88 | | Ketamine | 6.11 | Zaleplon | 3.76 | | Lorazepam | 3.93 | Zolpidem | 3.76 | | MDA | 6.76 | Zopiclone | 8.40 | | MDMA | 4.36 | THC-COOH | 8.14 | | MDPV | 5.65 | D-Amphetamine | 1.59 | | Meperidine | 2.84 | L-Amphetamine | 2.35 | | Meprobamate | 3.94 | D-Methamphetamine | 7.54 | | Methadone | 3.93 | L-Methamphetamine | 3.09 | Note: Ten different lots of oral fluid fortified with QC material to a concentration of 75 ng/mL and the %CV determined of the analyte per internal standard area ratio
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Note: Ten different lots of oral fluid fortified with QC material to a concentration of 75 ng/mL and the %CV determined of the analyte per internal standard area ratio |