Quantifying 64 drugs, illicit substances, and D- and L- isomers in human oral fluid with liquid-liquid extraction

Table 8.

Stability with concomitantmedications

% Diff from MEOH Spike

Drug / Metabolite

Dextromethorphan

Phenylephrine

Diphenhydramine

Salicylic Acid

Phentermine

OTC Mix

6-MAM

5.39

2.41

3.68

1.56

-8.41

-7.78

7-Amino Clonazepam

10.72

8.18

12.04

33.47

-2.47

-3.61

Alprazolam

9.27

2.99

7.65

14.10

-1.38

-2.03

Amitriptyline

3.11

2.96

8.50

7.57

0.10

-1.86

Amphetamine

-0.92

-0.06

-0.84

1.89

-0.06

1.39

a-OH Alprazolam

-0.83

2.54

0.06

4.41

4.71

-11.52

Benzoylecgonine

-1.03

6.40

0.22

2.51

9.56

11.44

Buprenorphine

4.23

2.26

-0.20

-1.07

-3.00

-0.86

Carisoprodol

-3.26

-0.50

5.13

15.63

3.65

-0.59

Chlordiazepoxide

0.96

0.34

2.35

2.07

0.34

0.33

Clonazepam

6.15

7.14

16.19

34.17

0.08

0.14

Codeine

13.56

14.51

6.73

-15.03

-0.35

6.84

Cotinine

1.22

3.48

3.92

2.92

3.17

-2.21

Cyclobenzaprine

4.09

-1.03

2.01

4.16

-1.94

-4.27

Desalkylflurazepam

8.09

7.14

10.06

38.05

5.65

-3.29

Desipramine

-1.45

2.43

0.43

-3.89

0.31

-3.13

Diazepam

1.13

3.37

2.48

-5.65

-1.78

-2.52

Dihydrocodeine

0.62

0.79

-7.21

3.27

3.78

-1.00

Doxepin

0.23

4.39

2.31

0.83

1.58

-0.64

EDDP

1.90

0.28

0.19

-3.66

2.54

-3.46

Fentanyl

-1.40

1.54

3.41

0.29

7.39

-2.49

Fluoxetine

-1.69

4.26

2.23

2.50

-0.35

-1.47

Gabapentin

-11.11

-8.90

-4.18

-2.32

19.22

-13.38

Hydrocodone

6.16

-2.30

3.15

-11.25

6.89

4.67

Hydromorphone

1.28

1.26

18.21

-12.76

-7.42

-1.09

Imipramine

-2.95

-0.25

4.92

2.80

6.61

14.32

Ketamine

-2.95

-0.25

4.92

2.80

6.61

-4.10

Lorazepam

-0.88

-3.20

7.82

16.67

-1.02

-3.45

MDA

4.59

5.12

7.04

-0.89

-7.19

-6.86

MDMA

0.60

3.63

-3.09

-8.02

-0.52

1.36

MDPV

3.95

3.01

-0.89

1.69

-1.13

0.14

Meperidine

-1.77

-0.99

1.10

-0.57

4.74

1.55

Meprobamate

3.82

0.70

3.78

0.56

1.04

0.40

Methadone

-2.63

-0.39

-2.11

-6.01

0.73

-1.11

Methamphetamine

6.15

3.95

6.10

2.67

-2.29

-1.34

Methylphenidate

-1.50

0.49

-0.28

0.67

3.21

1.19

Morphine

1.68

2.00

1.62

-7.46

4.21

1.92

Naloxone

-4.45

-2.67

-9.62

-2.56

-9.02

3.23

Naltrexone

-0.33

-0.66

-1.65

-2.72

5.19

-6.07

Nicotine

-0.98

-0.95

6.01

-3.25

-1.76

-3.54

Norbuprenorphine

-0.49

-4.07

-0.15

-0.22

0.10

-1.60

Nordiazepam

6.90

6.95

15.20

34.26

3.76

-2.96

Norfentanyl

7.69

15.16

7.72

-11.99

14.82

1.37

Norhydrocodone

0.52

19.05

9.66

-1.51

11.61

-0.85

Norketamine

3.12

-0.17

8.56

-0.95

-2.72

-5.45

Noroxycodone

-2.46

-2.81

10.90

17.18

-5.45

-4.41

Noroxymorphone

4.29

0.50

3.46

15.05

1.84

-6.40

Nortriptyline

2.86

1.00

3.95

1.59

-1.52

4.69

O-desmethyl Tramadol

-6.42

2.66

-1.98

4.48

12.13

-7.60

Oxazepam

0.63

-0.74

1.86

-2.35

1.21

-1.92

Oxycodone

5.93

1.50

-4.83

-9.02

-12.78

15.17

Oxymorphone

3.75

-2.74

-0.13

-2.40

3.74

-1.73

Paroxetine

1.54

3.91

6.26

0.71

2.68

-5.17

Phencyclidine

-4.40

2.95

-5.07

0.72

8.75

-6.18

Pregabalin

32.10

7.43

-0.44

3.95

-2.33

12.00

Ritalinic Acid

2.93

1.66

2.32

5.83

5.40

3.83

Tapentadol

1.61

4.28

5.77

0.29

8.08

0.35

Temazepam

-0.73

1.88

2.39

-3.55

0.39

1.35

Tramadol

4.16

2.43

3.01

2.80

2.19

1.42

Venlafaxine

-2.84

-1.08

-3.37

-2.58

4.23

-3.12

Zaleplon

4.85

1.81

2.18

2.85

-2.68

-1.70

Zolpidem

1.03

0.03

0.77

1.05

1.59

-2.96

Zopiclone

-1.91

-4.91

-3.47

-18.30

-0.47

-3.27

THC-COOH

0.66

-5.77

1.05

7.18

-3.65

10.25

D-Amphetamine

-0.77

-1.64

-2.00

1.06

-0.94

-3.90

L-Amphetamine

-1.97

-0.41

2.07

1.30

3.21

-0.54

D-Methamphetamine

-6.26

5.53

-6.10

-3.81

7.45

-5.96

L-Methamphetamine

-2.10

-0.24

-0.08

0.71

7.73

-0.12

Note: The indicated medications prepared in methanol were spiked into a QC 75 standard and measured. The data indicates percent difference from a QC standard spiked with blank methanol at the same volume as the drug standards.

Note: The indicated medications prepared in methanol were spiked into a QC 75 standard and measured. The data indicates percent difference from a QC standard spiked with blank methanol at the same volume as the drug standards.