Nicotinic agonists promoted the activation of nicotinic acetylcholine α7 receptors (α7 nAChR) in neurons, but failed to activate these receptors in mouse peritoneal macrophages

Table 4.

Number of RAW264.7 cells that responded to stimulation with ATP-Na+ (1 mM), withacetylcholine (ACh; 1 mM) and with ACh (100 μM) associated with PNU-120596(10 μM) by the whole cell patch clamp technique. (+): Presence of ioniccurrent greater than basal noise.

ATP

1 mM

ACh 1 mM or ACh 0,1 mM + PNU 10 μM

+

-

+

0

20

-

0

5