Nicotinic agonists promoted the activation of nicotinic acetylcholine α7 receptors (α7 nAChR) in neurons, but failed to activate these receptors in mouse peritoneal macrophages
Table 5.
Number ofperitoneal macrophages stimulated with LPS for 4 h that responded tostimulation with ATP-Na+ (1 mM) and with acetylcholine (ACh; 100μM) associated with PNU-120596 (10 μM) by the whole cell patch clamptechnique. (+): Presence of ionic current greater than basal noise.
| ATP 1 mM | ACh 0,1 mM + PNU 10 μM | | + | - | | + | 0 | 23 | | - | 0 | 0 |
|
|
