Cyclophosphamide Induces Hepatorenal Toxicity and Attenuation by 5-fluorouracil in Male Albino Rats

Table 2.

Serum LDH, ALT,AST, and AL of rat treated with cyclophosphamide and/or 5-fluorouracil

Groups Parameters	Control	CPA	5-FU	CPA – 5-FU
Groups Parameters	Mean±SE	Mean±SE	Mean±SE	Mean±SE
Serum LDH (IU/l)	1109 ±164^bcd	2086 ±187^ac	1632 ±90^abd	2150 ±265^bc
Serum ALT (IU/l)	24.4±11.4^bcd	129.4±8.5^acd	38.6±3.9^ab	42.4±9.4^ab
Serum AST (IU/l)	116.6±6.2^bcd	372.4±22^acd	147±8.7^ab	151.8±6.6^ab
Serum ALP (IU/l)	128.8±9.02^bcd	298.6±23.5^acd	151±4.1^abd	231.4±24.2^abc
Serum bilirubin (g/dl)	0.228±0.013^bcd	0.424±0.026^acd	0.284±0.010^ab	0.280±0.021^ab

Significance at P > 0.05. CPA: cyclophosphamide; 5-FU: Fluorouracil, ^a Comparison of control and other groups; ^b Comparison of CPA and other groups_;^c Comparison of 5-FU and other groups; ^d Comparison of CPA – 5-FU and other groups.

Cyclophosphamide Induces Hepatorenal Toxicity and Attenuation by 5-fluorouracil in Male Albino Rats

Table 2.

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