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World Journal of Clinical Medicine Research
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  5. Volume 2, Number 1, 2022
  6. Article
  7. Table 3

Cyclophosphamide Induces Hepatorenal Toxicity and Attenuation by 5-fluorouracil in Male Albino Rats

Table 3.

Serum urea, creatinine, and uric acid concentrations of rat treated with cyclophosphamide and/or 5-fluorouracil

Groups

Parameters

Control

CPA

5-FU

CPA – 5-FU

Mean±SE

Mean±SE

Mean±SE

Mean±SE

Serum urea concentration (g/dl)

19.66±1.53 ab

32.54±4.2 acd

24.52±2.53 abd

20.52±1.01 bc

Serum creatinine concentration (g/dl)

0.65±0.03 b

078±0.07 acd

0.64±0.03 b

0.62±0.07 b

Serum uric acid concentration (g/dl)

2.34±0.25 ab

1.08±0.17 acd

1.43±0.17 abd

1.50±0.09 bc

Significance at P > 0.05. CPA: cyclophosphamide; 5-FU: Fluorouracil, a Comparison of control and other groups; b Comparison of CPA and other groups; c Comparison of 5-FU and other groups; d Comparison of CPA – 5-FU and other groups.
Significance at P > 0.05. CPA: cyclophosphamide; 5-FU: Fluorouracil, a Comparison of control and other groups; b Comparison of CPA and other groups; c Comparison of 5-FU and other groups; d Comparison of CPA – 5-FU and other groups.