Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

Table 5.

Synthesis of Studies on Deliriumin Patients with Advanced Cancer

Theme Subtheme Study Findings

Prevalence of Delirium in Advanced Cancer Patients Delirium prevalence in palliative care for advanced cancer Mercadante et al. (2018) [41] - 17.5% of advanced cancer patients experienced delirium during palliative care - Delirium decreased to 10.3% after one week of intervention
Chishi et al. (2023) [10] - Delirium prevalence rate of 24.1% - Improvement observed after palliative intervention
Maeda et al. (2020) [39] - 22.1% of advanced cancer patients experienced delirium during palliative care
Prevalence of delirium in diverse palliative care settings De La Cruz et al. (2015) [11] - A 10.3% delirium prevalence rate among cancer patients admitted to an acute palliative care unit- A 30.5% delirium incidence rate in patients admitted to an acute palliative care unit
Chishi et al. (2023) [10] - A 62% delirium prevalence rate among patients admitted to a hospice center - Reduced to 24.1% with treatment
Mercadante et al. (2018) [41] - 11.5% delirium prevalence rate among advanced cancer patients in home care and hospice
Management and Treatment of Delirium in Advanced Cancer Patients Efficacy of pharmacological interventions in the management of delirium in advanced cancer Agar et al. (2017) [1] - Risperidone and haloperidol are more effective than placebo in reducing delirium symptoms - No significant difference between the two antipsychotics in terms of efficacy or safety
Okuyama et al. (2019) [45] - Current pharmacotherapy did not improve the severity of hypoactive delirium in patients with advanced cancer
Maeda et al. (2020) [39] - Antipsychotic medication for delirium was effective and safe in real-world palliative care settings
Efficacy of non-pharmacological approach in management of delirium in advanced cancer Tatematsu et al. (2011) [48] - Exercise therapy effective in reducing delirium in cancer patients
Mercadante et al. (2018) [41] - Palliative care associated with a reduction in the incidence and severity of delirium
Matsuda et al. (2020) [40] - Multicomponent interventions involving non-pharmacological approaches were effective- Environmental modifications reduced the severity and duration of delirium
Chishi et al. (2023) [10] - Addressing the physical, emotional, and spiritual needs of the patient showed positive impacts- Incorporating palliative care interventions may be effective in managing delirium
Reversibility of Delirium in Hospitalised Cancer Patients   Mercadante et al. (2018) [41], Chishi et al. (2023) [10], Matsuda et al. (2021) [40], - Delirium in hospitalized cancer patients generally reversible- Improvements observed with palliative care interventions, antipsychotic medications, and exercise therapy
  Matsuda et al. (2021) [40], - Delirium reversibility rate may vary depending on the underlying etiology- Identifying and managing underlying etiologies crucial in improving delirium outcomes
  Okuyama et al. (2019) [45], - Pharmacotherapy for managing delirium symptoms may have limited efficacy in hypoactive delirium subtype
  Agar et al. (2017) [1] - Risperidone and haloperidol effective in managing delirium symptoms in palliative care patients