5-fluorouracil Improves the Testicular Antioxidant Status and Alleviates Oxidative Stress in Male Albino Rats Treated with Cyclophosphamide

Table 2.

Testes TBARS, glutathione and Testesnitric oxide of rat treated with cyclophosphamide and/or 5-fluorouracil

Groups

Parameters

Control

CPA

5-FU

CPA – 5-FU

Mean±SE

Mean±SE

Mean±SE

Mean±SE

Testes TBARS (U/g tissue)

2.87±0.49 bcd

10.78±0.64acd

8.08±0.84abd

5.09±0.74abc

Testes nitric oxide (U/g tissue)

443.6±57.14 bd

727.2±35.63 acd

460.8±132.26 bd

558.4±61.51 abc

Significance at P > 0.05. CPA: cyclophosphamide; 5-FU: Fluorouracil, a Comparison of control and other groups; b Comparison of CPA and other groups; c Comparison of 5-FU and other groups; d Comparison of CPA – 5-FU and other groups

Significance at P > 0.05. CPA: cyclophosphamide; 5-FU: Fluorouracil, a Comparison of control and other groups; b Comparison of CPA and other groups; c Comparison of 5-FU and other groups; d Comparison of CPA – 5-FU and other groups