Depression, Subjective Health, Obesity, and Multimorbidity are Associated with Epigenetic Age Acceleration

Table 2.

Heatmap showing age and sex-adjustedassociations

  1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

1 HORVATH 1.00 .43* .27* .57* .52* -.16* .19* .16* .06* -.24* .24* .06* .08* .03 .05* .03* .03 .01 .04* .03 .00

2 HANNUM   1.00 .41* .53* .35* .13* .30* .22* .36* -.15* .39* .19* .07* .07* .05* .04* .01 -.01 .04* .08* .03

3 LEVINE     1.00 .23* .33* .32* .43* .04* .38* -.26* .14* .35* .13* .11* .05* .07* .03 .01 .10* .13* .04*

4 HORVATH-SKIN   1.00 .37* -.09* .19* .17* .07* -.14* .38* .09* .08* .04* .03* .04* .03 .01 .06* .07 .04*

5 LIN         1.00 .13* .28* -.05* .09* -.30* .17* .06* .04* .03 .01 .03* .00 -.01 .03* .01 -.01

6 WEIDNER           1.00 .52* .11* .20* -.06* .04* .11* -.01 .01 .02 .02 .00 -.02 .02 .02 .00

7 VIDALBRALO         1.00 -.09* .35* -.50* .05* .25* .07* .03* .07* .04* .01 .01 .03* .05* .01

8 YANG           1.00 .10* .22* .16* -.01 .01 .06* .02 -.02 .00 -.01 .03 .12* .07*

9 ZHANG                 1.00 -.15* .04* .52* .17* .11* .06* .07* .08* .05* .08* .18* .10*

10 BOCKLANDT                 1.00 .00 -.13* -.02 .01 -.04* .00 .00 -.03* .01 .01 .03*

11 GARAGNANI                   1.00 .08* .04* .03 .02 .02 .02 .02 .02 .04* .04*

12 GRIMAGE                       1.00 .22* .11* .04* .09* .10* .05* .07* .23* .13*

13 CMC n                         1.00 .50* .28* .49* .33* .44* .32* .46* .29*

14 Diabetes                           1.00 .03* .11* .08* .08* .26* .28* .13*

15 Cancer                             1.00 .06* .00 .05* .04* .05* -.01

16 Heart Disease                     1.00 .12* .09* .10* .21* .10*

17 Stroke                       1.00 .08* .05* .16* .11*

18 Psychiatric Conditions                       1.00 .06* .19* .33*

19 BMI                         1.00 .26* .11*

20 SRH                             1.00 .41*

21 CES-D                               1.00