Articles

<b>Objective:</b> This integrative review aims to critically examine the clinical management of periprosthetic joint infections (PJI) in total hip arthroplasty (THA), emphasizing decision-making strategies, diagnostic advancements, and therapeutic innovations. The study focuses on the complexity of infection control, microbial resistance, and individualized treatment planning. <b>Methods:</b><b> </b>A systematic review of the literature was conducted using PubMed, Scopus, Web of Science, and Google Scholar, targeting studies published between 2015 and 2025. Articles were selected based on their contribution to understanding the clinical, microbiological, and surgical aspects of PJI in THA. Fifty-five studies met the inclusion criteria and were analyzed descriptively.<b> </b><b>Results:</b><b> </b>PJI in THA is influenced by multifactorial risk profiles, including obesity, diabetes, and immunosuppression. Staphylococcus aureus, particularly MRSA, remains the most frequently isolated pathogen, followed by Gram-negative organisms and fungal species. Diagnostic innovations such as next-generation sequencing have enhanced pathogen detection, while two-stage revision remains the gold standard for chronic infections. Emerging strategies—such as antimicrobial coatings, tailored antibiotic protocols, and multidisciplinary care models—demonstrate promise in improving clinical outcomes. <b>Conclusion:</b><b> </b>Managing PJI in THA necessitates a comprehensive and individualized approach, integrating early and accurate diagnosis, pathogen-specific treatment, and advanced preventive measures. The integration of emerging technologies and personalized care pathways is critical to optimizing outcomes and reducing the clinical and economic burden of PJI.

Artificial Immune Systems (AIS) are bio-inspired computational frameworks that emulate the adaptive mechanisms of the human immune system, such as self/non-self discrimination, clonal selection, and immune memory. These systems have demonstrated significant potential in addressing complex challenges across optimization, anomaly detection, and adaptive system control. This paper provides a comprehensive exploration of AIS applications in domains such as cybersecurity, resource allocation, and autonomous systems, highlighting the growing importance of hybrid AIS models. Recent advancements, including integrations with machine learning, quantum computing, and bioinformatics, are discussed as solutions to scalability, high-dimensional data processing, and efficiency challenges. Core algorithms, such as the Negative Selection Algorithm (NSA) and Clonal Selection Algorithm (CSA), are examined, along with limitations in interpretability and compatibility with emerging AI paradigms. The paper concludes by proposing future research directions, emphasizing scalable hybrid frameworks, quantum-inspired approaches, and real-time adaptive systems, underscoring AIS's transformative potential across diverse computational fields.

Smallholder farmers face challenges when they lack information on their agricultural activities. To address this, we suggest a web-based system that can be used by farmers to help them in decision making considering the fact that all necessary information is provided by the system. Farmers can input crop type they want to grow and area. This data will help to recommend them the best crops that are suitable to be grown in that area and the necessary growing practices that can be done to produce high yield and have maximum profits, considering the average rainfall of that year. A persistent issue we face in Zimbabwe is the lack of access to reliable agricultural data. In the agricultural sector, one major uncertainty for farmers is the outlook of their future harvest. Once their produce is ready for sale, the presence of other potential buyers compels traders to offer prices that align closely with those in the formal market. However, without timely information, traders can take advantage of the situation by purchasing crops at unfairly low rates. Having data that tracks prices across various markets in near real-time would enable farmers to have a precise and complete understanding of their selling choices to maximize their profits.

In the current study, the eight-bar planar mechanism is balanced by reducing variations in shaking force and moments using Minitab and a genetic algorithm. The objective function and constraint equations are taken into consideration, the mathematical model was developed to optimize the balancing of the planar eight-bar mechanism.A set of weighting factors were taken into consideration in order to determine the ideal values for the design parameters based on the contributions of the X and Y components of the shaking force and the shaking moment. A genetic algorithm was used to find the best design parameters. The results showed that the shaking force and moments decreased by 34.5 and 61% from the initial values, respectively.

Advances in web-centric cloud computing have facilitated the establishment of an integrated cloud environment connecting a wide variety of clinical trial stakeholders. A web-centric cloud framework is proposed for real-time monitoring and risk prediction during clinical trials. The framework focuses on identifying relevant datasets, developing a data-management interface, and implementing machine-learning algorithms for data analysis. Detailed descriptions of the data-management interface and the machine-learning processes are provided, targeting active clinical trials with therapeutic uses in cancer. Demonstrations utilize publicly available clinical-trial data from the ClinicalTrials.gov repository. The real-time monitoring and risk prediction systems were assessed by developing five supervised-classification-machine-learning models for trial-status prediction and six unsupervised models for patient-safety-profile assessment, each representing a different phase of the clinical-trial process. All supervised models yielded high accuracy and area-under-the-curve values at the testing stage, while the unsupervised models demonstrated practical applicability. The results underscore the advantages of using the trial-status algorithm, the patient-safety-profile model, and the proposed framework for performing real-time monitoring and risk prediction of clinical trials.

The Blockchain technology uses different type of database that transact data in blocks and then chained each data blocks. When data fills one block, it is chained the same data onto previous block therefore, all the data blocks are stored in chronological order. The blockchain technology can help to ensure that data in supply chain is reliable, accurate and can be shared with all stakeholders without any manipulation. It makes supply chain more transparent and end-to-end digital visibility of data source. Blockchain is stringent technology which fill the gap between stakeholders by providing transparent unmanipulated and truthful data in supply chain. There are many initiatives has been taken by multiple regulatory bodies with partnering with supply chain stakeholders including pharmaceutical manufacturer, distributors and dispensers. In USA, Food and Drug Administration’s regulatory body Drug Supply Chain Security Act (DSCSA) initi-ated pilot program in 2019 with the partnership of leading pharmaceuticals distributors to au-thenticating saleable returns to distributor from supply chain partners. DSCSA used MediLedger blockchain interoperable technology for process evaluation and it robustness for mitigating risk of drug counterfeiting possibilities in supply chain. The DSCSA found that pilot project was suc-cessful and results were astonishing. Later it was declared that blockchain technology can also be used for meeting DSCSA’s 2023 Act for unit level traceability.

Aiming at the time complexity of singular value spectrum weighted Hankel SVD filtering algorithm, a clutter suppression algorithm for ultrasonic color Doppler imaging based on BP neural network model is proposed in this paper. Firstly, using the PRF data collected by portable ultrasound instrument, we verify the singular value weighted Hankel SVD filtering algorithm, and the results show that the algorithm has high accuracy; Then, the BP neural network model is established based on the input and output data of singular value weighted Hankel-SVD filtering algorithm; Finally, the clutter suppression algorithm of ultrasonic color Doppler imaging based on BP neural network model is established. The experimental results show that compared with Hankel SVD filtering algorithm, the clutter suppression algorithm proposed in this paper greatly shortens the operation time without reducing the accuracy, so as to improve the real-time performance of the filtering algorithm.

An algorithm is defined as a finite step-by-step procedure to accomplish a required result. It is also defined as a sequence of computational operations that convert the given input into the required output. In general, in the worst case, an algorithm is said to be optimal if there are no algorithms that perform a less basic number of well-defined operations, in the worst case. This paper presents an optimal algorithm for finding the second smallest among n numbers. The complexity of the proposed algorithm and its advantages are also analyzed in this paper.

Emerging smart medical instruments combined with advanced smart industrial equipment facilitate the collection of vast volumes of critical data. This data not only enables significantly more accurate and cost-effective diagnosis and maintenance but also enriches the datasets available for AI algorithms, leading to improved insights and outcomes. The integration of high-speed and ultra-reliable telecommunications infrastructure is crucial, as it supports the cloud model. This model allows for off-device aggregation in the cloud, which effectively offloads infrastructure demands and provides an extended runway for future technological improvements before the deployment of the next generation of devices. However, in certain scenarios, latency and bandwidth limitations present significant challenges. These limitations require that a substantial amount of AI and machine learning processing is conducted directly on the transmitted data, which places rigorous demands on both the processing subsystems and the communications links themselves. The current project directly addresses the accelerator side of this multifaceted issue. It will carry out comprehensive end-to-end demonstrations leveraging pilot 5G networks and telemedicine facilities, collaborating closely with major industry participants to showcase the capabilities and potential of this innovative technology. This collaborative effort is essential to pushing the boundaries of what is possible in smart medical instruments and industrial applications [1].

Cell division that is not controlled leads to cancer, an incurable condition. An early diagnosis has the potential to lower death rates from breast cancer, the most frequent disease in women worldwide. Imaging studies of the breast may help doctors find the disease and diagnose it. This study explores an effectiveness of DL and ML models in a classification of mammography images for breast cancer detection, utilizing the publicly available CBIS-DDSM dataset, which comprises 5,000 images evenly divided between benign and malignant cases. To improve diagnostic accuracy, models such as Gaussian Naïve Bayes (GNB), CNNs, KNN, and MobileNetV2 were assessed employing performance measures including F1-score, recall, accuracy, and precision. The methodology involved data preprocessing techniques, including transfer learning and feature extraction, followed by data splitting for robust model training and evaluation. Findings indicate that MobileNetV2 achieved a highest accuracy99.4%, significantly outperforming GNB (87.2%), CNN (96.7%), and KNN (91.2%). The outstanding capacity of MobileNetV2 to identify between benign and malignant instances was shown by the investigation, which also made use of confusion matrices and ROC curves to evaluate model performance.

The multitude of services and resources available in multi-cloud environments has increased the importance of analytics applications in cloud brokering. These applications can orchestrate services and resources that reside in different domains and require inputs that a single cloud provider could not easily acquire. Yet, despite their distinct characteristics, multi-cloud analytics users have no voice in the ranking of the services in brokerage marketplaces. In this chapter, we introduce the concept and propose the implementation of explainable analytics to increase transparency and user satisfaction in multi-cloud environments. The criteria that we have identified and measured in order to summarize them in explainable results allow cloud users to acquire an understanding of the ranking rules, a crucial requirement in trustful decision-making. Our proposal accounts for a set of regulations for intelligent systems and targets their specific adaptation and use in multi-cloud environments.

Effective task scheduling in cloud computing is crucial for optimizing system performance and resource utilization. Traditional scheduling methods often struggle to adapt to the dynamic and complex nature of cloud environments, where workloads, resource availability, and task requirements constantly change. Swarm intelligence-based optimization algorithms, such as Particle Swarm Optimization (PSO), Ant Colony Optimization (ACO), and Artificial Bee Colony (ABC), offer a promising solution by mimicking natural processes to explore large search spaces efficiently. These algorithms are effective in balancing multiple objectives, including minimizing execution time, reducing energy consumption, and ensuring fairness in resource allocation. They also enhance system scalability, which is vital for modern cloud infrastructures. However, challenges remain, including slow convergence speeds, complex parameter tuning, and integration with existing cloud frameworks. Addressing these issues will be essential for the practical implementation of swarm intelligence in cloud task scheduling, helping to improve resource management and overall system performance.