Articles

<i><b>Background. </b></i>Guanylate cyclase 1 soluble subunit alpha 2 (<i>sGC</i><i>α2</i>), also known as <i>GUCY1A2</i>, was reported to be upregulated and promoted tumorigenesis in cervical cancer. But whether <i>GUCY1A2</i> was abnormally expressed and its prognostic value in gastric cancer was unknown. The current study aimed to find out the prognostic value of <i>GUCY1A2</i> in gastric cancer by analyzing data from The Cancer Genome Atlas (TCGA) database. <i><b>Methods.</b></i> Wilcoxon signed-rank test, cox regression analysis and multivariant analysis were used to analyze the relationship between clinical characteristic and <i>GUCY1A2</i> expression level. Kaplan-Meier method was used to analyze the association of <i>GUCY1A2</i> and overall survival. Gene set enrichment analysis (GSEA) was used to identify <i>GUCY1A2</i>-related signaling pathway. <i><b>Results.</b></i> Compared to normal tissue, expression of <i>GUCY1A2</i> was significantly increased in gastric cancer (p<0.001). Increased <i>GUCY1A2</i> was associated with advanced T stage (p=0.012) and poor survival (p=0.022). Univariate analysis showed that high <i>GUCY1A2 </i>expression was associated with a poor overall survival (HR:1.44, 95% confidence interval [CI]: 1.03-2.02, p=0.03). Multivariate analysis indicated that <i>GUCY1A3</i> remained an independent prognostic predictor of overall survival (HR:1.75, 95% confidence interval [CI]: 1.20-2.56, p=0.00). GSEA revealed that calcium signaling pathway, <i>MAPK </i>signaling pathway, <i>TGF-β</i> signaling pathway and <i>Wnt</i> signaling pathway were enriched in <i>GUCY1A2 </i>high expression phenotype. <i><b>Conclusions.</b></i> <i>GUCY1A2</i> maybe a potential prognostic predictor of poor survival in gastric cancer. But it need to be further validated clinically.