Commentary Open Access January 10, 2025

Clinical characteristics of COVID-19 patients who received ventilator management during the omicron variant period in a tertiary hospital in Japan

1
Division of Infectious Diseases and Infection Control, Saitama Medical University International Medical Center, Hidaka City, Japan
2
Division of Pharmacy, Saitama Medical University International Medical Center, Hidaka City, Japan
Page(s): 1-5
Received
December 09, 2024
Revised
January 02, 2025
Accepted
January 09, 2025
Published
January 10, 2025
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2025. Published by Scientific Publications
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APA Style
Seki, M. , Seki, M. Kubosawa, C. , Kubosawa, C. Ono, M. , Ono, M. Kamoshita, F. , Kamoshita, F. Shimizu, A. , & Shimizu, A. (2025). Clinical characteristics of COVID-19 patients who received ventilator management during the omicron variant period in a tertiary hospital in Japan. Current Research in Public Health, 5(1), 1-5. https://doi.org/10.31586/wjcmr.2025.1231
ACS Style
Seki, M. ; Seki, M. Kubosawa, C. ; Kubosawa, C. Ono, M. ; Ono, M. Kamoshita, F. ; Kamoshita, F. Shimizu, A. ; Shimizu, A. Clinical characteristics of COVID-19 patients who received ventilator management during the omicron variant period in a tertiary hospital in Japan. Current Research in Public Health 2025 5(1), 1-5. https://doi.org/10.31586/wjcmr.2025.1231
Chicago/Turabian Style
Seki, Masafumi, Masafumi Seki. Chie Kubosawa, Chie Kubosawa. Makoto Ono, Makoto Ono. Fumitaka Kamoshita, Fumitaka Kamoshita. Atsuko Shimizu, and Atsuko Shimizu. 2025. "Clinical characteristics of COVID-19 patients who received ventilator management during the omicron variant period in a tertiary hospital in Japan". Current Research in Public Health 5, no. 1: 1-5. https://doi.org/10.31586/wjcmr.2025.1231
AMA Style
Seki M, Seki MKubosawa C, Kubosawa COno M, Ono MKamoshita F, Kamoshita FShimizu A, Shimizu A. Clinical characteristics of COVID-19 patients who received ventilator management during the omicron variant period in a tertiary hospital in Japan. Current Research in Public Health. 2025; 5(1):1-5. https://doi.org/10.31586/wjcmr.2025.1231
@Article{crph1231,
AUTHOR = {Seki, Masafumi and Kubosawa, Chie and Ono, Makoto and Kamoshita, Fumitaka and Shimizu, Atsuko and Mitsutake, Kotaro},
TITLE = {Clinical characteristics of COVID-19 patients who received ventilator management during the omicron variant period in a tertiary hospital in Japan},
JOURNAL = {Current Research in Public Health},
VOLUME = {5},
YEAR = {2025},
NUMBER = {1},
PAGES = {1-5},
URL = {https://www.scipublications.com/journal/index.php/WJCMR/article/view/1231},
ISSN = {2831-5162},
DOI = {10.31586/wjcmr.2025.1231},
ABSTRACT = {Background: Severe COVID-19 patients who received ventilator management were not very rare even when the omicron variant became dominant, but the clinical characteristics of these patients are still unclear. Methods: The clinical characteristics of severe COVID-19 patients requiring ventilator management were retrospectively investigated from January 2023 to December 2023. Results: Severe COVID-19 patients who received ventilator management accounted for 11 of 275 (4.2%) patients during the omicron variant period. Their mean age was 70.7 (51-85) years, and males were predominant. Ten of eleven (91.7%) patients were managed in the emergency department and had underlying diseases, including chronic lung/heart/kidney diseases and neurological diseases. However, only 4 of 11 (36.4%) had a clear history of vaccination. The patients showed a positive SARS-CoV-2 antigen titer of 3305.7 (12.9-20912). All 11 patients were treated with remdesivir and dexamethasone, and 5 (45.5%) also received sotrovimab. Pathogenic bacteria were isolated from 7 of 11 (63.6%) patients, and all 11 patients were treated with antibiotics. Only 3 of 11 (27.3%) patients were managed using extracorporeal membrane oxygenation (ECMO), but 9 of 11(81.8%) patients survived. Conclusions: These data suggest that severe COVID-19 patients who required ventilator management were less-vaccinated, elderly patients with underlying disease. These patients were treated successfully using antiviral agents, steroids, neutralizing antibodies, and antibiotics, with a few also treated using ECMO in the omicron era.},
}
%0 Journal Article
%A Seki, Masafumi
%A Kubosawa, Chie
%A Ono, Makoto
%A Kamoshita, Fumitaka
%A Shimizu, Atsuko
%A Mitsutake, Kotaro
%D 2025
%J Current Research in Public Health

%@ 2831-5162
%V 5
%N 1
%P 1-5

%T Clinical characteristics of COVID-19 patients who received ventilator management during the omicron variant period in a tertiary hospital in Japan
%M doi:10.31586/wjcmr.2025.1231
%U https://www.scipublications.com/journal/index.php/WJCMR/article/view/1231
TY  - JOUR
AU  - Seki, Masafumi
AU  - Kubosawa, Chie
AU  - Ono, Makoto
AU  - Kamoshita, Fumitaka
AU  - Shimizu, Atsuko
AU  - Mitsutake, Kotaro
TI  - Clinical characteristics of COVID-19 patients who received ventilator management during the omicron variant period in a tertiary hospital in Japan
T2  - Current Research in Public Health
PY  - 2025
VL  - 5
IS  - 1
SN  - 2831-5162
SP  - 1
EP  - 5
UR  - https://www.scipublications.com/journal/index.php/WJCMR/article/view/1231
AB  - Background: Severe COVID-19 patients who received ventilator management were not very rare even when the omicron variant became dominant, but the clinical characteristics of these patients are still unclear. Methods: The clinical characteristics of severe COVID-19 patients requiring ventilator management were retrospectively investigated from January 2023 to December 2023. Results: Severe COVID-19 patients who received ventilator management accounted for 11 of 275 (4.2%) patients during the omicron variant period. Their mean age was 70.7 (51-85) years, and males were predominant. Ten of eleven (91.7%) patients were managed in the emergency department and had underlying diseases, including chronic lung/heart/kidney diseases and neurological diseases. However, only 4 of 11 (36.4%) had a clear history of vaccination. The patients showed a positive SARS-CoV-2 antigen titer of 3305.7 (12.9-20912). All 11 patients were treated with remdesivir and dexamethasone, and 5 (45.5%) also received sotrovimab. Pathogenic bacteria were isolated from 7 of 11 (63.6%) patients, and all 11 patients were treated with antibiotics. Only 3 of 11 (27.3%) patients were managed using extracorporeal membrane oxygenation (ECMO), but 9 of 11(81.8%) patients survived. Conclusions: These data suggest that severe COVID-19 patients who required ventilator management were less-vaccinated, elderly patients with underlying disease. These patients were treated successfully using antiviral agents, steroids, neutralizing antibodies, and antibiotics, with a few also treated using ECMO in the omicron era.
DO  - Clinical characteristics of COVID-19 patients who received ventilator management during the omicron variant period in a tertiary hospital in Japan
TI  - 10.31586/wjcmr.2025.1231
ER  -