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Article Open Access June 26, 2025

The Relationship Between Lymphocyte Count and Mortality in Patients with Dysphagia

Min Wei 1, Chengming Ke 2 and Sumin Wu 1,*
1
Center of Excellence, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
2
Neuroscience Medical Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
Publihed in: Current Research in Public Health (Volume 5, Issue 1, 2025)
Page(s): 40-51
DOI: 10.31586/wjcmr.2025.6128
Received
April 22, 2025
Revised
June 06, 2025
Accepted
June 23, 2025
Published
June 26, 2025
Keywords
ALC; Dysphagia; Mortality; Survival Analysis
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright: Copyright © The Author(s), 2025. Published by Scientific Publications
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APA Style
Wei, M. , Ke, C. , & Wu, S. (2025). The Relationship Between Lymphocyte Count and Mortality in Patients with Dysphagia. Current Research in Public Health, 5(1), 40-51. https://doi.org/10.31586/wjcmr.2025.6128
ACS Style
Wei, M. ; Ke, C. ; Wu, S. The Relationship Between Lymphocyte Count and Mortality in Patients with Dysphagia. Current Research in Public Health 2025 5(1), 40-51. https://doi.org/10.31586/wjcmr.2025.6128
Chicago/Turabian Style
Wei, Min, Chengming Ke, and Sumin Wu. 2025. "The Relationship Between Lymphocyte Count and Mortality in Patients with Dysphagia". Current Research in Public Health 5, no. 1: 40-51. https://doi.org/10.31586/wjcmr.2025.6128
AMA Style
Wei M, Ke C, Wu S. The Relationship Between Lymphocyte Count and Mortality in Patients with Dysphagia. Current Research in Public Health. 2025; 5(1):40-51. https://doi.org/10.31586/wjcmr.2025.6128 
@Article{crph6128,
AUTHOR = {Wei, Min and Ke, Chengming and Wu, Sumin},
TITLE = {The Relationship Between Lymphocyte Count and Mortality in Patients with Dysphagia},
JOURNAL = {Current Research in Public Health},
VOLUME = {5},
YEAR = {2025},
NUMBER = {1},
PAGES = {40-51},
URL = {https://www.scipublications.com/journal/index.php/WJCMR/article/view/6128},
ISSN = {2831-5162},
DOI = {10.31586/wjcmr.2025.6128},
ABSTRACT = {Background: Dysphagia is a common functional impairment in elderly populations, often leading to severe complications such as malnutrition and aspiration pneumonia, significantly increasing healthcare burdens. Currently, effective prognostic assessment tools are lacking. The absolute lymphocyte count (ALC), a biomarker reflecting immune-nutritional status, has potential predictive value in this context, though its role in dysphagia prognosis remains unclear. Methods: This retrospective cohort study included 253 dysphagic patients who received percutaneous endoscopic gastrostomy (PEG) or total parenteral nutrition (TPN) between 2014 and 2017. Five patients with missing ALC were excluded. Cox regression models assessed the association between ALC and mortality. ALC was analyzed as both continuous variable (using restriocted cubic splines) and categorical tertiles, with additional threshold analyses to assess non-linearity. Kaplan–Meier survival curves and subgroup analyses were also performed. Results: Lower ALC was associated with poorer nutritional status, higher inflammatory markers, and greater comorbidity burden. Higher ALC was independently associated with reduced mortality (adjusted HR: 0.60; 95% CI: 0.44–0.83; p = 0.002). Patients in the highest tertile had significantly better survival than those in the lowest (HR: 0.37; 95% CI: 0.23–0.59; P < 0.001). A non-linear threshold effect was identified at ALC = 1.899×109/L (p for non-linearity = 0.009). Kaplan–Meier analysis confirmed improved survival with higher ALC (p < 0.0001). Subgroup analyses showed the protective effect of higher ALC was consistent across age, sex, BMI, PEG use, and comorbidity strata, with no significant interactions. Conclusions: ALC is an independent, non-linear predictor of mortality in older dysphagic patients and may aid clinical risk stratification across diverse patient subgroups.},
}
%0 Journal Article
%A Wei, Min
%A Ke, Chengming
%A Wu, Sumin
%D 2025
%J Current Research in Public Health

%@ 2831-5162
%V 5
%N 1
%P 40-51

%T The Relationship Between Lymphocyte Count and Mortality in Patients with Dysphagia
%M doi:10.31586/wjcmr.2025.6128
%U https://www.scipublications.com/journal/index.php/WJCMR/article/view/6128

TY  - JOUR
AU  - Wei, Min
AU  - Ke, Chengming
AU  - Wu, Sumin
TI  - The Relationship Between Lymphocyte Count and Mortality in Patients with Dysphagia
T2  - Current Research in Public Health
PY  - 2025
VL  - 5
IS  - 1
SN  - 2831-5162
SP  - 40
EP  - 51
UR  - https://www.scipublications.com/journal/index.php/WJCMR/article/view/6128
AB  - Background: Dysphagia is a common functional impairment in elderly populations, often leading to severe complications such as malnutrition and aspiration pneumonia, significantly increasing healthcare burdens. Currently, effective prognostic assessment tools are lacking. The absolute lymphocyte count (ALC), a biomarker reflecting immune-nutritional status, has potential predictive value in this context, though its role in dysphagia prognosis remains unclear. Methods: This retrospective cohort study included 253 dysphagic patients who received percutaneous endoscopic gastrostomy (PEG) or total parenteral nutrition (TPN) between 2014 and 2017. Five patients with missing ALC were excluded. Cox regression models assessed the association between ALC and mortality. ALC was analyzed as both continuous variable (using restriocted cubic splines) and categorical tertiles, with additional threshold analyses to assess non-linearity. Kaplan–Meier survival curves and subgroup analyses were also performed. Results: Lower ALC was associated with poorer nutritional status, higher inflammatory markers, and greater comorbidity burden. Higher ALC was independently associated with reduced mortality (adjusted HR: 0.60; 95% CI: 0.44–0.83; p = 0.002). Patients in the highest tertile had significantly better survival than those in the lowest (HR: 0.37; 95% CI: 0.23–0.59; P < 0.001). A non-linear threshold effect was identified at ALC = 1.899×109/L (p for non-linearity = 0.009). Kaplan–Meier analysis confirmed improved survival with higher ALC (p < 0.0001). Subgroup analyses showed the protective effect of higher ALC was consistent across age, sex, BMI, PEG use, and comorbidity strata, with no significant interactions. Conclusions: ALC is an independent, non-linear predictor of mortality in older dysphagic patients and may aid clinical risk stratification across diverse patient subgroups.
DO  - The Relationship Between Lymphocyte Count and Mortality in Patients with Dysphagia
TI  - 10.31586/wjcmr.2025.6128
ER  -