The Future of Longevity Medicine from the Lens of Digital Therapeutics

Journal of Artificial Intelligence and Big Data | Vol 5, Issue 1

Table 1. Details of digital therapeutics in Longevity currently available in the market

SlNo	Company Name & Country of Origin	Indication	Features
1	AgeX Therapeutics ¹⁶ United States	Regenerative Medicine	Specializes in regenerative medicine using pluripotent stem cells. Focused on tissue engineering and cell-based therapies.
2	Altos Labs ¹⁷ UK	Cellular Rejuvenation	Focuses on cellular rejuvenation programming to reverse age-related decline. High-profile team includes leading scientists and significant funding from Jeff Bezos.
3	Amazentis (Timeline)¹⁸ Switzerland	Mitophagy & Muscle Health	Pioneers in research on mitophagy and mitochondrial health. Offers Urolithin A-based products for improving muscle and cell performance.
4	Apollo Health Ventures¹⁹ Germany	Aging Research Investment	Venture capital firm targeting companies with potential breakthroughs in aging. Supports translational research to bridge science and application.
5	BioAge Labs ²⁰ United States	Aging Biomarker Discovery	Leverages human aging data to identify biomarkers and drug targets to combat aging-related diseases.
6	BioXtek²¹ United States	Regenerative Technology	Cutting-edge platform leverages the regenerative properties of amniotic membrane and other birth-derived tissues to address various age-related conditions.
7	Calico Labs²² United States	Aging-related Therapies	Backed by Google’s Alphabet, focused on understanding the biology of aging. Develops therapies targeting age-related diseases through collaboration with AbbVie.
8	Caristo Diagnostics²³ Oxford, England	Cardiovascular aging	AI-based tool capable of predicting heart attacks up to a decade in advance by assessing coronary inflammation. This technology provides clinicians with a powerful tool to identify at-risk individuals and implement preventive measures.
9	CHARACTER BIOSCIENCES ²⁴ USA	Disease Progression	Integrates genomics, longitudinal clinical and imaging data, machine learning, and novel experimental approaches to identify the molecular drivers of disease progression and develop innovative targeted medicines.
10	Chromadex (Tru Niagen)²⁵ United States	NAD+ Mitochondrial Health	Specializes in NAD+precursors to improve mitochondrial health. Products aimed at boosting energy and cellular repair.
11	Deep Longevity²⁶ Hong Kong	AI for Biological Age	Builds AI-driven models to measure biological age and predict longevity based on health and lifestyle factors.
12	Dorian Therapeutics ²⁷ USA	Senescence Therapies	They are developing senoblockers, a new class of therapeutics with a double function: blocking senescence while reactivating the regeneration capacity of a tissue.
13	Elysium Health²⁸ United States	NAD+ Boosters & Aging	Offers consumer-facing products like NAD+ boosters and health supplements. Develops and 12commercializes epigenetic biomarkers for aging.
14	Glycan age²⁹ UK	Biological Age Testing	Glycan Age is a simple, test that analyses glycobiology. Taking a GlycanAge® test is a vital step to determine once biological age.
15	Gero³⁰ Singapore	Aging Biomarker Models	Develops AI-driven solutions to study biomarkers of aging and resilience. Known for predictive models of healthspan.
16	Insilico Medicine ³¹ Hong Kong	Aging Research	Combines AI with genomics to identify therapeutic targets for age-related diseases. Leader in using deep learning for drug discovery and aging research.
17	Juvenescence ³² United Kingdom	Aging-related Diseases	A biotech company investing in and developing drugs to target aging and age-related conditions. Broad portfolio includes senolytics and metabolic regulators.
18	Libella Gene Therapeutics ³³ United States	Telomere Lengthening	Focused on telomere lengthening through gene therapy. Clinical trials for aging-related diseases are underway.
19	Life Biosciences ³⁴ United States	Cellular Health Aging	Aims to combat aging through research in epigenetics, mitochondrial health, and senescence. Focuses on restoring cellular health to extend lifespan.
20	Longevity Vision Fund ³⁵ United States	Aging & Longevity Investment	Focuses on funding startups in aging and longevity science. Invests in innovations targeting healthspan and lifespan extension.
21	MICREGEN ³⁶ UK	Stem Cell Therapies	Innovative approach in developing the Secretomix® platform to produce various secretome formulations from its first clinical grade master and working cell banks, could change how multiple critical and chronic problems are managed- not just the symptoms, but the root causes of diseases. They are primarily working on stem cells.
22	ONE SKIN ³⁷ USA	Skin Aging Reversal	Their products focus on skin longevity. One Skin’s proprietary peptide, OS-01, is an ingredient designed to reduce skin's biological age by improving skin barrier, supporting DNA damage repair, and preventing the accumulation of aged cells.
23	Oisín Biotechnologies ³⁸ USA	Aging-related diseases	Longevity therapeutics platform company focused on creating genetic medicines to combat a variety of age related diseases. Oisín Biotechnologies is developing a highly precise, DNA-targeted intervention to clear the senescent cells. As a recent study has shown, clearing senescent cells both reduces negative effects of aging pathologies and also extends median lifespan and survival.
24	PULSE SIGHT ³⁹ France	Age-related Macular Degeneration	Ophthalmology drug development company developing disruptive non-viral gene therapies with minimally invasive delivery technology to treat AMD.
25	Rejuvenate Bio ⁴⁰ United States	Gene Therapy Aging	Utilizes gene therapy to reverse age-related conditions in animals and humans. Targeting cardiovascular and metabolic diseases.
26	SUZHOU Ruiming⁴¹ China	Age-related Macular Degeneration	The company has developed an eye-drop drug delivery technology for fundus diseases which include age-related wet macular degeneration (AMD), retinal vein occlusion, and diabetic macular edema.
27	S-Biomedic ⁴² Belgium	Skin Health Solutions	Focused on skin health by pioneering the development of Pro- and Post-biotic ingredients from true skin commensals.
28	SeaBeLife Biotech ⁴³ France	Neurodegenerative diseases	Focuses on the development of molecules designed to block regulated necrosis – also known as regulated cell death.
29	Sirona Biochem Corp ⁴⁴ Canada	Skin Health Solutions	Developed a novel anti-aging compound designed to reverse the effects of aging on facial skin.
30	Thorne HealthTech ⁴⁵ United States	Personalized Longevity	Provides personalized health insights through testing kits. Focuses on nutritional solutions and longevity interventions.
31	Turn Biotechnologies ⁴⁶ United States	Epigenetic Reprogramming	Uses epigenetic reprogramming to restore youthful cell function. Targets applications in skin and muscle rejuvenation.
32	Unity Biotechnology ⁴⁷ United States	Senolytic Therapies	Focuses on eliminating senescent cells to address diseases like osteoarthritis, fibrosis, and neurodegenerative conditions.

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