Drug-Receptor Interaction of Peptidic HIV-1 Protease: The Hydrophobic Effect-I

Compd.No.

Substiunts

o(log1/C)

R₁

R2

R3

19

CH₂Ph

H

H

9.6

20

CH₂Ph

Me

H

8.11

21

CH₂CH₂Ph

H

OH

9.72

22

CH₂-4-CF₃Ph

H

H

9.59

23

CH₂CH=CHPh

H

H

9.64

24

CH₂C₆F₅

H

H

9.22

25

CH₂-4-CH₃Ph

H

H

9.54

26

CH₂-4-NH₂Ph

H

H

9.51

27

CH₂-4-NO₂Ph

H

H

9.57

28

H

H

H

5.53

29

CH₂-4-OHPh

H

H

9.8

30

CH₂CH=CH₂

H

H

7.56

31

CH₂-4-IPh

H

H

9.14

32

CH₂C(O)Ph

H

H

8.27

33

CH₂-4-Pyridyl

H

H

9.28

34

CH₂SPh

H

H

9.60

35

CH₂-4-CMe₃Ph

H

H

9.77