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Article

Drug-Receptor Interaction of Peptidic HIV-1 Protease: The Hydrophobic Effect-I

Table 2

Second set of fifty one peptidic HIV-1-PRIs with observed biologicalactivities

Compd.No.

Substiunts

o(log1/C)

R1

R2

R3

19

CH2Ph

H

H

9.6

20

CH2Ph

Me

H

8.11

21

CH2CH2Ph

H

OH

9.72

22

CH2-4-CF3Ph

H

H

9.59

23

CH2CH=CHPh

H

H

9.64

24

CH2C6F5

H

H

9.22

25

CH2-4-CH3Ph

H

H

9.54

26

CH2-4-NH2Ph

H

H

9.51

27

CH2-4-NO2Ph

H

H

9.57

28

H

H

H

5.53

29

CH2-4-OHPh

H

H

9.8

30

CH2CH=CH2

H

H

7.56

31

CH2-4-IPh

H

H

9.14

32

CH2C(O)Ph

H

H

8.27

33

CH2-4-Pyridyl

H

H

9.28

34

CH2SPh

H

H

9.60

35

CH2-4-CMe3Ph

H

H

9.77