Drug-Receptor Interaction of Peptidic HIV-1 Protease: The Hydrophobic Effect-I
Table 2.
Second set of fifty one peptidic HIV-1-PRIs with observed biologicalactivities
| Compd.No. | Substiunts | o(log1/C) | | R1 | R2 | R3 | | 19 | CH2Ph | H | H | 9.6 | | 20 | CH2Ph | Me | H | 8.11 | | 21 | CH2CH2Ph | H | OH | 9.72 | | 22 | CH2-4-CF3Ph | H | H | 9.59 | | 23 | CH2CH=CHPh | H | H | 9.64 | | 24 | CH2C6F5 | H | H | 9.22 | | 25 | CH2-4-CH3Ph | H | H | 9.54 | | 26 | CH2-4-NH2Ph | H | H | 9.51 | | 27 | CH2-4-NO2Ph | H | H | 9.57 | | 28 | H | H | H | 5.53 | | 29 | CH2-4-OHPh | H | H | 9.8 | | 30 | CH2CH=CH2 | H | H | 7.56 | | 31 | CH2-4-IPh | H | H | 9.14 | | 32 | CH2C(O)Ph | H | H | 8.27 | | 33 | CH2-4-Pyridyl | H | H | 9.28 | | 34 | CH2SPh | H | H | 9.60 | | 35 | CH2-4-CMe3Ph | H | H | 9.77 |
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