Drug-Receptor Interaction of Peptidic HIV-1 Protease: The Hydrophobic Effect-I
Table 7. SASA,SASAd, SASAr and ΔSASAdr of compounds of the first set
| S.N. |
| SASA |
|
|
| Binding Site |
| Catalytic Site | |||||||||||||
 Val |  Ile |
|  Asp |  Thr |  Gly | ||||||||||||||||
| Substituent-R |
| Substituent-X |
| Substituent-Y |
| Substituent-Z |
| SASAr = 17.28 | SASAr = 24.16 |
| SASAr = 20.69 | SASAr = 15.66 | SASAr = 0 | ||||||||
| SASAH | SASAR |
| SASAH | SASAX |
| SASAH | SASAY |
| SASAH | SASAZ |
| ΔSASAdr | ΔSASAdr |
| ΔSASAdr | ΔSASAdr | ΔSASAdr | ||||
| 1 |
| 220.62 |
| 174.78 | 45.85 |
| 220.62 | 0.00 |
| 212.52 | 8.10 |
| 212.54 | 8.08 |
| 28.57 | 21.69 |
| 25.16 | 30.19 | ----- |
| 2 |
| 234.86 |
| 192.21 | 42.65 |
| 234.86 | 0.00 |
| 226.78 | 8.08 |
| 208.27 | 26.59 |
| 25.37 | 18.49 |
| 21.96 | 26.99 | ----- |
| 3 |
| 247.04 |
| 195.96 | 51.08 |
| 247.04 | 0.00 |
| 239.18 | 7.86 |
| 218.10 | 28.94 |
| 33.80 | 26.92 |
| 30.39 | 35.42 | ----- |
| 4 |
| 247.07 |
| 192.35 | 54.72 |
| 247.07 | 0.00 |
| 237.92 | 9.15 |
| 226.11 | 20.96 |
| 37.44 | 30.56 |
| 34.03 | 39.06 | ----- |
| 5 |
| 233.90 |
| 191.55 | 42.36 |
| 233.90 | 0.00 |
| 217.06 | 16.84 |
| 219.56 | 14.34 |
| 25.08 | 18.20 |
| 21.67 | 26.70 | ----- |
| 6 |
| 230.66 |
| 190.56 | 40.09 |
| 230.66 | 0.00 |
| 227.66 | 3.00 |
| 211.84 | 18.82 |
| 22.81 | 15.93 |
| 19.40 | 24.43 | ----- |
| 7 |
| 231.08 |
| 188.72 | 42.36 |
| 231.08 | 0.00 |
| 226.30 | 4.78 |
| 206.95 | 24.13 |
| 25.08 | 18.20 |
| 21.67 | 26.70 | ----- |
| 8 |
| 240.17 |
| 191.60 | 48.57 |
| 240.17 | 0.00 |
| 232.63 | 7.54 |
| 216.63 | 23.54 |
| 31.29 | 24.41 |
| 27.88 | 32.91 | ----- |
| 9 |
| 244.21 |
| 192.96 | 51.24 |
| 244.21 | 0.00 |
| 230.23 | 13.98 |
| 220.44 | 23.77 |
| 33.96 | 27.08 |
| 30.55 | 35.58 | ----- |
| 10 |
| 257.24 |
| 208.38 | 48.86 |
| 257.24 | 0.00 |
| 230.84 | 26.40 |
| 236.43 | 20.81 |
| 31.58 | 24.70 |
| 28.17 | 33.20 | ----- |
| 11 |
| 249.78 |
| 207.76 | 42.02 |
| 249.78 | 0.00 |
| 220.52 | 29.26 |
| 235.09 | 14.69 |
| 24.74 | 17.86 |
| 21.33 | 26.36 | ----- |
| 12 |
| 251.20 |
| 196.86 | 54.34 |
| 251.20 | 0.00 |
| 237.28 | 13.92 |
| 223.30 | 27.90 |
| 37.06 | 30.18 |
| 33.65 | 38.68 | ----- |
| 13 |
| 257.99 |
| 210.81 | 47.17 |
| 257.99 | 0.00 |
| 225.50 | 32.49 |
| 232.14 | 25.85 |
| 29.89 | 23.01 |
| 26.48 | 31.51 | ----- |
| 14 |
| 264.17 |
| 202.17 | 62.00 |
| 264.17 | 0.00 |
| 239.92 | 24.25 |
| 240.75 | 23.42 |
| 44.72 | 37.84 |
| 41.31 | 46.34 | ----- |
| 15 |
| 249.16 |
| 213.92 | 35.24 |
| 249.30 | -0.14 |
| 221.87 | 27.29 |
| 232.86 | 16.30 |
| 17.96 | 11.08 |
| 14.55 | 19.58 | ----- |
| 16 |
| 261.52 |
| 216.47 | 45.05 |
| 253.96 | 7.56 |
| 232.31 | 29.21 |
| 236.48 | 25.04 |
| 27.77 | 20.89 |
| 24.36 | 29.39 | ----- |
| 17 |
| 245.27 |
| 202.48 | 42.80 |
| 245.27 | 0.00 |
| 231.08 | 14.19 |
| 223.11 | 22.16 |
| 25.52 | 18.64 |
| 22.11 | 27.14 | ----- |
| 18 |
| 247.64 |
| 205.52 | 42.11 |
| 247.64 | 0.00 |
| 228.85 | 18.79 |
| 228.50 | 19.14 |
| 24.83 | 17.95 |
| 21.42 | 26.45 | ----- |
|
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