Drug-Receptor Interaction of Peptidic HIV-1 Protease: The Hydrophobic Effect-I
Table 9. SASA,SASAd, SASAr and ΔSASAdr of compounds of the third set.
| S.N. |
| SASA |
|
|
| Binding Site |
| Catalytic Site | ||||
 Val |  Ile |
|  Asp |  Thr |  Gly | |||||||
| Substituent-X |
| SASAr = 17.28 | SASAr = 24.16 |
| SASAr = 20.69 | SASAr = 15.66 | SASAr = 0 | |||||
| SASAH | SASAX |
| ΔSASAdr | ΔSASAdr |
| ΔSASAdr | ΔSASAdr | ΔSASAdr | ||||
| 36 |
| 204.14 |
| 173.54 | 30.60 |
| 13.32 | 6.44 |
| 9.91 | 14.94 | ----- |
| 37 |
| 196.90 |
| 173.54 | 23.36 |
| 6.08 | 0.80 |
| 2.67 | 7.70 | ----- |
| 38 |
| 210.24 |
| 173.54 | 36.70 |
| 19.42 | 12.54 |
| 16.01 | 21.04 | ----- |
| 39 |
| 209.14 |
| 173.54 | 35.60 |
| 18.32 | 11.44 |
| 14.91 | 19.94 | ----- |
| 40 |
| 200.29 |
| 173.54 | 26.75 |
| 9.47 | 2.590 |
| 6.06 | 11.09 | ----- |
| 41 |
| 238.92 |
| 173.54 | 65.38 |
| 48.10 | 41.22 |
| 44.69 | 49.72 | ----- |
| 42 |
| 236.15 |
| 173.54 | 62.61 |
| 45.33 | 38.45 |
| 41.92 | 46.95 | ----- |
| 43 |
| 196.47 |
| 173.54 | 22.93 |
| 5.65 | 1.230 |
| 2.24 | 7.27 | ----- |
| 44 |
| 211.99 |
| 173.54 | 38.45 |
| 21.17 | 14.29 |
| 17.76 | 22.79 | ----- |
| 45 |
| 240.08 |
| 173.54 | 66.54 |
| 49.26 | 42.38 |
| 45.85 | 50.88 | ----- |
| 46 |
| 230.73 |
| 173.54 | 57.19 |
| 39.91 | 33.03 |
| 36.50 | 41.53 | ----- |
| 47 |
| 199.90 |
| 173.54 | 26.36 |
| 9.08 | 2.200 |
| 5.67 | 10.70 | ----- |
| 48 |
| 209.20 |
| 173.54 | 35.66 |
| 18.38 | 11.50 |
| 14.97 | 20.00 | ----- |
| 49 |
| 215.38 |
| 173.54 | 41.84 |
| 24.56 | 17.68 |
| 21.15 | 26.18 | ----- |
| 50 |
| 209.80 |
| 173.54 | 36.26 |
| 18.98 | 12.10 |
| 15.57 | 20.60 | ----- |
| 51 |
| 207.86 |
| 173.54 | 34.32 |
| 17.04 | 10.16 |
| 13.63 | 18.66 | ----- |
