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Article

Drug-Receptor Interaction of Peptidic HIV-1 Protease: The Hydrophobic Effect-I

Table 9

SASA,SASAd, SASAr and ΔSASAdr of compounds of the third set.

S.N.

 

SASA

 

 

Binding Site

 

Catalytic Site

Val

Ile

 

Asp

Thr

Gly

Substituent-X

 

SASAr =

17.28

SASAr =

24.16

 

SASAr =

20.69

SASAr =

15.66

SASAr =

0

SASAH

SASAX

 

ΔSASAdr

ΔSASAdr

 

ΔSASAdr

ΔSASAdr

ΔSASAdr

36

 

204.14

 

173.54

30.60

 

13.32

6.44

 

9.91

14.94

-----

37

 

196.90

 

173.54

23.36

 

6.08

0.80

 

2.67

7.70

-----

38

 

210.24

 

173.54

36.70

 

19.42

12.54

 

16.01

21.04

-----

39

 

209.14

 

173.54

35.60

 

18.32

11.44

 

14.91

19.94

-----

40

 

200.29

 

173.54

26.75

 

9.47

2.590

 

6.06

11.09

-----

41

 

238.92

 

173.54

65.38

 

48.10

41.22

 

44.69

49.72

-----

42

 

236.15

 

173.54

62.61

 

45.33

38.45

 

41.92

46.95

-----

43

 

196.47

 

173.54

22.93

 

5.65

1.230

 

2.24

7.27

-----

44

 

211.99

 

173.54

38.45

 

21.17

14.29

 

17.76

22.79

-----

45

 

240.08

 

173.54

66.54

 

49.26

42.38

 

45.85

50.88

-----

46

 

230.73

 

173.54

57.19

 

39.91

33.03

 

36.50

41.53

-----

47

 

199.90

 

173.54

26.36

 

9.08

2.200

 

5.67

10.70

-----

48

 

209.20

 

173.54

35.66

 

18.38

11.50

 

14.97

20.00

-----

49

 

215.38

 

173.54

41.84

 

24.56

17.68

 

21.15

26.18

-----

50

 

209.80

 

173.54

36.26

 

18.98

12.10

 

15.57

20.60

-----

51

 

207.86

 

173.54

34.32

 

17.04

10.16

 

13.63

18.66

-----