Wernicke’s Encephalopathy: A Series of 7 Cases and Literature Review
Table 2.
Comparative table of IV thiamine protocols in Wernickeencephalopathy
|
| Society / Reference |
Initial dosage |
Acute-phase duration |
Maintenance dose |
Oral switch |
Particularities / precautions |
|
|
Royal College of Physicians (UK)
Thomson et al., 2002 |
500 mg IV every 8 h |
≥ 2-3 days |
250 mg/day IV for 5 days |
100-200 mg/day |
Administer before glucose; dilute in 100 mL 0.9% NaCl; monitor Mg²⁺ |
|
|
EFNS (Europe)
Galvin et al., 2010 |
500 mg IV every 8 h |
≥ 3 days |
250 mg/day IV or IM |
100-200 mg/day oral |
Protocol widely used in neurology; also used in prevention (alcoholism, bariatric surgery, hyperemesis gravidarum) |
|
|
| USA (UpToDate / NIH 2023) |
500 mg IV every 8 h |
2-3 days |
250 mg/day for 3–5 days |
100-200 mg/day |
Prevention: 100 mg IV/day for high-risk patients; systematic magnesium supplementation |
|
|
| Consensus practice (Lancet Neurol 2022) |
≥ 500 mg IV every 8 h |
2-3 days |
250 mg/day for 3–5 days |
100-200 mg/day |
Most widely recommended regimen; optimal for preventing Korsakoff syndrome |
|
|
|
|
