Bioinformatic Analysis of GCN1 as a Novel Diagnostic and Prognostic Biomarker in Hepatocellular Carcinoma and Preliminary Exploration of Its Molecular Mechanisms
Table 3.
Univariate and Multivariate Cox RegressionResults
|
| Characteristics |
HR (95% CI) |
P value |
|
|
| a. |
|
|
|
| Pathologic T stage (T2&T3&T4VS.T1) |
2.126 (1.481 - 3.052) |
< 0.001 |
|
| Pathologic N stage (N1 VS. N0) |
2.029 (0.497 - 8.281) |
0.324 |
|
| Pathologic M stage (M1 VS. M0) |
4.077 (1.281 - 12.973) |
0.017 |
|
| Gender (Female VS. Male) |
1.261 (0.885 - 1.796) |
0.200 |
|
| Age (> 60 VS.<= 60) |
1.205 (0.850 - 1.708) |
0.295 |
|
| BMI (> 25 VS.<= 25) |
0.798 (0.550 - 1.158) |
0.235 |
|
| AFP (ng/ml) (> 400 VS.<= 400) |
1.075 (0.658 - 1.759) |
0.772 |
|
| Albumin(g/dl) (>= 3.5 VS.< 3.5) |
0.897 (0.549 - 1.464) |
0.662 |
|
| Prothrombin time (> 4 VS.<= 4) |
1.335 (0.881 - 2.023) |
0.174 |
|
| Vascular invasion (Yes VS. No) |
1.344 (0.887 - 2.035) |
0.163 |
|
| GCN1 expression (High VS. Low) |
1.604 (1.133 - 2.271) |
0.008 |
|
| b. |
|
|
|
| Pathologic T stage (T2&T3&T4VS.T1) |
2.010 (1.395 - 2.897) |
< 0.001 |
|
| GCN1 expression (High VS. Low) |
1.454 (1.021 - 2.070) |
0.038 |
|
|
|
