The study aimed at examining farmers’ perceptions on the impacts of climate change on food crops and the farming practices that contribute to climate change (CC) in Bibiani – Ahwiaso – Bekwai municipality of Western North Region of Ghana. Qualitative and quantitative methods were used for this study. The population of the study consisted of the number of households in six communities (Hwenampori, Wenchi, Tanoso, Awaso-Asempanaye, Kunkumso, and Sefwi Bekwai), officials from MoFA, GMA, and heads of households who are food crop farmers from the study area. Simple random and purposive sampling techniques were used to select respondents for the study. 231 respondents were selected and contacted for information to aid them in the study. The main instruments for data collection were the administration of questionnaires to farmers, organization of focus group discussions with key informants, the use of structured interview guides on MoFA directorates and direct observation of some farms. The primary and secondary data were sourced mainly from household heads from the study communities who are in the production of maize, cassava, and plantain. Pearson Chi-Square and Cross-tabulation of the IBM SPSS Version 20 were also used in performing descriptive statistical analysis. The study revealed that the output of maize, cassava, and plantain have all proved to be negatively impacted by changes in rainfall and temperature patterns with a more significant impact observed from maize responses to temperature. The study also indicated that the impact of climate change may affect the crops at any stage of the production process right from the land preparation to the maturity stage of crops but the more profound effect is observed at fruit development and maturation stages. The study indicated that changes in temperature affect crop yield, especially during the fruit/seed development stage. The study revealed that most farmers (about 92.2%) have observed climate change in the study area and indicated events like unpredictable rainfall patterns, excessively high temperatures and strong winds. It is recommended that capacity building and awareness creation should be enhanced by GMA and MoFA through the media to ensure that communication about climate change and food security is meaningful. This means that education on diversification of farming methods has not been enough if there is any at all in the area. Awareness creation, therefore, allows people to make informed and responsible decisions toward sustainable farming practices which will lead to food security and also environmental sustainability.