Air pollution is currently considered a global problem in both developing and developed countries. Substances that invade our spaces are components of air pollution that cause a strong negative impact on health for those who are exposed, not only in the cardiovascular and respiratory systems but are being related to the etiology of pathologies throughout the body, with a decrease in life expectancy and even an increase in mortality and alterations of the genetic material. This literature review aims to collect employing a search the implications that the components of air pollution have on the health of those exposed, from a clinical and molecular point of view. For the search, the DeCS descriptors created by BIREME were used: air pollution, cardiovascular system, respiratory diseases. The following databases were consulted: PubMed, ScienceDirect, and Scopus. The search criteria considered the year of publication and whether the original language was English or Spanish. It was concluded that the study of the different particles and the consequences that exposure to them entails is of vital importance for the development of control, prevention, and treatment mechanisms; since they can generate pathologies that range from something as tangible as lung diseases and occlusive heart disease to epigenetic changes that affect health.