The last few years have seen an increased adoption of cloud infrastructure, which has in turn led to a growth in large-scale distributed architectures in data centers to accommodate cloud resource elasticity and resiliency better. Selecting the right approach to build secure, scalable, and reliable cloud infrastructure within a budget is always a challenge. This text focuses on offering practical solutions for designing and building a secure, scalable, and reliable cloud-based infrastructure where auto-scaling and multi-region deployments are the two key approaches to offer high availability. It covers designing secure and scalable microservices using cloud platforms. The content will provide an understanding of public cloud architecture, the design of microservices running on the cloud, and also the design patterns used in the cloud era. With real-world examples, you will learn how microservices can enable scalable distributed systems. Furthermore, you will be walked through multi-region deployments, auto-scaling, and traffic management in cloud environments, using a sample environment setup and useful tips and tricks for monitoring. Finally, you will see a mock implementation of cloud infrastructure on-premise for a private cloud or single-node cloud. By the end of this text, you will be able to build, manage, and deploy a highly scalable and reliable cloud-ready solution [1].