Enterprise databases are the heart of applications and contain the most sensitive and critical information of organizations. While there have been significant advances in the security of databases, vulnerabilities still exist due to mistakes made by application developers, database administrators, and users. Manual detection and patching of such vulnerabilities typically take months, but an automated detection and remediation framework is proposed to fill the gap and eliminate a significant number of these vulnerabilities in near-real time. This framework comprises two key components: a detection engine that leverages static analysis to identify potential patches, coupled with query dynamic testing and fuzzing to identify exploitable misconfigurations; and an orchestration engine that applies detected patches on the database, validates the accuracy of the fix, and rolls back changes if the problem is not resolved. A prototype of this framework has been implemented and validated on a real-time database deployed in an enterprise environment. Because of the complexity of the problem landscape, the research focus is on static vulnerability detection and automated corrective actions. These two capabilities can greatly reduce the manual workload associated with vulnerability detection and significantly enhance the assurance that the granted privileges validate the least privilege principle. The proposed architecture aims to enable the deployment of a detection-and-remediation solution that minimizes human effort, reduces the enterprise-at-risk window, and maximizes the volume of detected vulnerabilities.