The purpose of this study was to examine the challenges faced by students of Colleges of Education (CoEs) in developing their Information Literacy skills. The study adopted the post-positivism paradigm. Descriptive survey research design used in this study Survey. The population for this study comprised all Level 200 students at Wiawso CoE, Enchi CoE, and Bia Lamplighter CoE in the Western North Region. Purposive, stratified, and convenience sampling techniques were used to select colleges of education and level 200 students. The three (3) colleges of education were stratified and purposively selected while 256 level 200 students were stratified and conveniently sampled. The study employed questionnaires to collect data from the sampled students. Questionnaires (open and closed-ended questions) focused on the challenges faced by the students in developing their Information Literacy (IL) skills. The quantitative data was captured, analysed, and presented in descriptive statistics such as percentages, and frequency tables, to determine the objective of the study. It is recommended that to improve digital literacy and academic pursuits, the college management should improve access to desktop computers and the Internet in the library and computer centre. It is also recommended that Management and librarians of the Colleges of Education ensure that students have access to these devices at the library and can use them to develop their IL skills and help them manage their references more effectively.