Drug-Receptor Interaction of Peptidic HIV-1 Protease: Polar Effect-II

Online Journal of Microbiological Research | Vol 2, Issue 1

Table 6. ΔE^‡_nm value derived from interaction betweenreceptor protein of enzyme and inhibitors

Compd. No.	Carbon Atom	E^‡_n(eff)	Val	Ile	Compd. No.	Oxygen Atom	E^‡_m(eff)	Val	Ile
			(E^‡_m(eff) =-26.850)	(E^‡_m(eff) =-26.435)				(E^‡_n(eff) =54.482)	(E^‡_n(eff) =55.280)
			ΔE^‡_nm	ΔE^‡_nm				ΔE^‡_nm	ΔE^‡_nm
Group A 1	C11	56.480	82.915	83.330	1	O13	-28.032	82.514	83.312
2	C11	56.859	83.709	83.294	2	O13	-27.693	82.175	82.973
3	C11	55.809	82.659	82.244	3	O13	-28.872	83.354	84.152
4	C11	55.999	82.849	82.434	4	O13	-28.427	82.909	83.707
5	C7	55.529	82.379	81.964	5	O13	-30.771	85.253	86.051
6	C7	55.362	82.212	81.797	6	O13	-30.198	84.680	85.478
7	C11	55.582	82.432	82.017	7	O13	-28.876	83.358	84.156
8	C11	56.444	83.294	82.879	8	O13	-26.478	80.960	81.758
9	C11	56.372	83.222	82.807	9	O13	-22.298	76.780	77.578
10	C7	55.573	82.423	82.008	10	O13	-29.608	84.090	84.888
11	C11	55.961	82.811	82.396	11	O13	-29.661	84.143	84.941
12	C7	55.910	82.760	82.345	12	O13	-29.367	83.849	84.647
13	C11	56.349	83.199	82.784	13	O13	-28.869	83.351	84.149
14	C11	56.139	82.989	82.574	14	O13	-28.097	82.579	83.377
15	C11	56.518	83.368	82.953	15	O13	-28.445	82.927	83.725
16	C11	55.569	82.419	82.004	16	O13	-27.897	82.379	83.177
17	C11	56.003	82.853	82.438	17	O13	-29.154	83.636	84.434
18	C11	55.698	82.548	82.133	18	O13	-28.434	82.916	83.714
Group B 19	C21	56.510	83.360	82.945	19	O23	-26.012	80.494	81.292
20	C22	56.396	83.246	82.831	20	O23	-26.864	81.346	82.144
21	C22	56.311	83.161	82.746	21	O23	-26.062	80.544	81.342
22	C21	56.712	83.562	83.147	22	O23	-25.602	80.084	80.882
23	C21	56.526	83.376	82.961	23	O23	-26.017	80.499	81.297
24	C7	57.200	84.050	83.635	24	O23	-25.624	80.106	80.904
25	C22	56.291	83.141	82.726	25	O32	-26.390	80.872	81.670
26	C22	56.170	83.020	82.605	26	O32	-26.417	80.899	81.697
27	C21	56.590	83.440	83.025	27	O32	-25.490	79.972	80.770
28	C22	56.676	83.526	83.111	28	O23	-25.626	80.108	80.906
29	C22	56.225	83.075	82.660	29	O32	-26.480	80.962	81.760
30	C22	56.297	83.147	82.732	30	O32	-26.202	80.684	81.482
31	C21	56.579	83.429	83.014	31	O23	-25.972	80.454	81.252
32	C7	56.437	83.287	82.872	32	O32	-24.795	79.277	80.075
33	C21	56.624	83.474	83.059	33	O23	-25.752	80.234	81.032
34	C21	56.618	83.468	83.053	34	O23	-25.721	80.203	81.001
35	C21	56.213	83.063	82.648	35	O32	-26.332	80.814	81.612
Group C 36	C12	56.327	83.177	82.762	36	O21	-27.011	81.493	82.291
37	C11	56.389	83.239	82.824	37	O21	-26.680	81.162	81.960
38	C11	56.539	83.389	82.974	38	O29	-26.696	81.178	81.976
39	C12	56.662	83.512	83.097	39	O13	-26.466	80.948	81.746
40	C11	56.578	83.428	83.013	40	O13	-25.314	79.796	80.594
41	C11	56.507	83.357	82.942	41	O13	-26.678	81.160	81.958
42	C11	56.009	82.859	82.444	42	O13	-26.137	80.619	81.417
43	C11	56.111	82.961	82.546	43	O13	-26.234	80.716	81.514
44	C11	56.483	83.333	82.918	44	O13	-26.385	80.867	81.665
45	C11	55.926	82.776	82.361	45	O13	-27.401	81.883	82.681
46	C7	55.980	82.830	82.415	46	O13	-27.006	81.488	82.286
47	C11	56.564	83.414	82.999	47	O29	-26.879	81.361	82.159
48	C11	56.515	83.365	82.950	48	O29	-26.731	81.213	82.011
49	C11	56.666	83.516	83.101	49	O29	-26.150	80.632	81.430
50	C7	56.567	83.417	83.002	50	O29	-26.150	80.632	81.430
51	C11	56.396	83.246	82.831	51	O29	-26.023	80.505	81.303

Drug-Receptor Interaction of Peptidic HIV-1 Protease: Polar Effect-II

Table 6. ΔE‡nm value derived from interaction betweenreceptor protein of enzyme and inhibitors

Table 6. ΔE^‡_nm value derived from interaction betweenreceptor protein of enzyme and inhibitors